Plekho1 (pleckstrin homology domain containing, family O member 1) - Rat Genome Database

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Gene: Plekho1 (pleckstrin homology domain containing, family O member 1) Mus musculus
Analyze
Symbol: Plekho1
Name: pleckstrin homology domain containing, family O member 1
RGD ID: 1322972
MGI Page MGI
Description: Acts upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Located in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2810052M02Rik; CK2 interacting protein 1; CKIP; CKIP-1; Ckip1; Jun zipper-associated 2; Jza; JZA-2; JZA-20; Jza2; MGC151380; PH domain-containing family O member 1; pleckstrin homology domain-containing family O member 1; TNF intracellular domain-interacting protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,896,121 - 95,903,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,895,741 - 95,903,313 (-)EnsemblGRCm39 Ensembl
GRCm38395,988,809 - 95,999,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,988,429 - 95,996,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,792,751 - 95,799,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,074,233 - 96,081,244 (-)NCBIMGSCv36mm8
Celera397,422,723 - 97,429,850 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1631061   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14729969   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16987810  
PMID:17197158   PMID:18641638   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22553210   PMID:23151343   PMID:23747421   PMID:24777252   PMID:25240053   PMID:27481061   PMID:27666961  
PMID:28083909   PMID:28128304   PMID:28212865   PMID:28286065   PMID:28351752   PMID:28404913   PMID:29422872   PMID:29956799   PMID:30053453   PMID:30683852   PMID:30824383   PMID:31168669  
PMID:32626993   PMID:32826457   PMID:33191205   PMID:33276097   PMID:34347073   PMID:34498492   PMID:34875910  


Genomics

Comparative Map Data
Plekho1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,896,121 - 95,903,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl395,895,741 - 95,903,313 (-)EnsemblGRCm39 Ensembl
GRCm38395,988,809 - 95,999,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,988,429 - 95,996,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv37395,792,751 - 95,799,762 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,074,233 - 96,081,244 (-)NCBIMGSCv36mm8
Celera397,422,723 - 97,429,850 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
PLEKHO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,149,646 - 150,160,065 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,149,183 - 150,164,720 (+)EnsemblGRCh38hg38GRCh38
GRCh371150,121,836 - 150,132,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,388,794 - 148,398,449 (+)NCBINCBI36Build 36hg18NCBI36
Celera1123,237,889 - 123,247,544 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,502,507 - 121,511,229 (+)NCBIHuRef
CHM1_11151,518,106 - 151,527,756 (+)NCBICHM1_1
T2T-CHM13v2.01149,274,323 - 149,284,749 (+)NCBIT2T-CHM13v2.0
Plekho1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22183,544,487 - 183,552,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,544,499 - 183,552,785 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,208,081 - 191,216,052 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02189,012,540 - 189,020,482 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02183,840,633 - 183,848,604 (-)NCBIRnor_WKY
Rnor_6.02198,112,104 - 198,120,202 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,112,076 - 198,120,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,601,880 - 217,609,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,787,503 - 190,796,057 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,750,270 - 190,758,811 (-)NCBI
Celera2176,073,021 - 176,080,794 (-)NCBICelera
Cytogenetic Map2q34NCBI
Plekho1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413603,128 - 616,015 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955413603,011 - 606,487 (-)NCBIChiLan1.0ChiLan1.0
PLEKHO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,147,114 - 129,157,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,146,459 - 129,157,401 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01125,494,740 - 125,504,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLEKHO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,402,758 - 59,411,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,402,834 - 59,411,788 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,849,824 - 58,858,981 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,398,910 - 60,408,051 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,398,979 - 60,408,250 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,248,504 - 59,257,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,332,396 - 59,341,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,059,457 - 60,068,599 (+)NCBIUU_Cfam_GSD_1.0
Plekho1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,409,723 - 21,416,853 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936580440,111 - 448,651 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLEKHO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,923,996 - 98,934,189 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,924,115 - 98,934,610 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,197,951 - 108,208,439 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLEKHO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,137,552 - 13,148,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plekho1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,889,560 - 17,901,213 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,889,528 - 17,898,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1189
Count of miRNA genes:607
Interacting mature miRNAs:730
Transcripts:ENSMUST00000015889, ENSMUST00000123006, ENSMUST00000130043, ENSMUST00000143485, ENSMUST00000157043
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015889   ⟹   ENSMUSP00000015889
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,895,741 - 95,903,313 (-)Ensembl
GRCm38.p6 Ensembl395,988,429 - 95,996,001 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123006   ⟹   ENSMUSP00000118665
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,896,131 - 95,902,980 (-)Ensembl
GRCm38.p6 Ensembl395,988,819 - 95,995,668 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130043   ⟹   ENSMUSP00000115035
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,896,707 - 95,903,034 (-)Ensembl
GRCm38.p6 Ensembl395,989,395 - 95,995,722 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143485   ⟹   ENSMUSP00000114505
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,898,780 - 95,903,178 (-)Ensembl
GRCm38.p6 Ensembl395,991,468 - 95,995,866 (-)Ensembl
RefSeq Acc Id: ENSMUST00000157043
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl395,902,647 - 95,903,110 (-)Ensembl
GRCm38.p6 Ensembl395,995,335 - 95,995,798 (-)Ensembl
RefSeq Acc Id: NM_023320   ⟹   NP_075809
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,896,140 - 95,903,151 (-)NCBI
GRCm38395,988,828 - 95,995,839 (-)NCBI
MGSCv37395,792,751 - 95,799,762 (-)RGD
Celera397,422,723 - 97,429,850 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501930   ⟹   XP_006501993
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,896,121 - 95,903,300 (-)NCBI
GRCm38395,988,809 - 95,999,355 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240206   ⟹   XP_011238508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39395,896,121 - 95,902,980 (-)NCBI
GRCm38395,988,809 - 95,995,668 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075809   ⟸   NM_023320
- UniProtKB: Q9CXH2 (UniProtKB/Swiss-Prot),   Q9JIY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501993   ⟸   XM_006501930
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011238508   ⟸   XM_011240206
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000115035   ⟸   ENSMUST00000130043
RefSeq Acc Id: ENSMUSP00000114505   ⟸   ENSMUST00000143485
RefSeq Acc Id: ENSMUSP00000015889   ⟸   ENSMUST00000015889
RefSeq Acc Id: ENSMUSP00000118665   ⟸   ENSMUST00000123006
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIY0-F1-model_v2 AlphaFold Q9JIY0 1-408 view protein structure

Promoters
RGD ID:6847756
Promoter ID:MM_ACW:32585
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:PLEKHO1.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,793,016 - 95,795,482 (-)MPROMDB
RGD ID:6834254
Promoter ID:MM_KWN:35343
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   MEF_B6
Transcripts:OTTMUST00000052703,   OTTMUST00000052704,   OTTMUST00000052705,   OTTMUST00000078523,   OTTMUST00000078524
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36395,800,386 - 95,800,886 (-)MPROMDB
RGD ID:6881628
Promoter ID:EPDNEW_M4265
Type:initiation region
Name:Plekho1_1
Description:Mus musculus pleckstrin homology domain containing, family Omember 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38395,995,920 - 95,995,980EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914470 AgrOrtholog
Ensembl Genes ENSMUSG00000015745 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000015889 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114505.2 UniProtKB/TrEMBL
  ENSMUSP00000115035.2 UniProtKB/TrEMBL
  ENSMUSP00000118665.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015889 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000123006.8 UniProtKB/TrEMBL
  ENSMUST00000130043.8 UniProtKB/TrEMBL
  ENSMUST00000143485.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CKIP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKHO1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67220 UniProtKB/Swiss-Prot
MGD MGI:1914470 ENTREZGENE
NCBI Gene 67220 ENTREZGENE
PANTHER PTHR15871 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15871:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plekho1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YVD1_MOUSE UniProtKB/TrEMBL
  F6VV25_MOUSE UniProtKB/TrEMBL
  F6XQM2_MOUSE UniProtKB/TrEMBL
  PKHO1_MOUSE UniProtKB/Swiss-Prot
  Q9CXH2 ENTREZGENE
  Q9JIY0 ENTREZGENE
UniProt Secondary Q9CXH2 UniProtKB/Swiss-Prot