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Gene: EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4) Homo sapiens
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Symbol: EIF2AK4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
RGD ID: 1322904
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity. Involved in cellular response to cold; eiF2alpha phosphorylation in response to endoplasmic reticulum stress; and regulation of eIF2 alpha phosphorylation by amino acid starvation. Predicted to localize to cytosolic ribosome and polysome. Implicated in pulmonary venoocclusive disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: eIF-2-alpha kinase GCN2; eukaryotic translation initiation factor 2-alpha kinase 4; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; general control nonderepressible 2; KIAA1338; PVOD2
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1539,934,115 - 40,035,591 (+)EnsemblGRCh38hg38GRCh38
GRCh381539,934,115 - 40,035,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371540,226,331 - 40,327,797 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,013,639 - 38,115,089 (+)NCBINCBI36hg18NCBI36
Build 341538,033,406 - 38,115,083NCBI
Celera1516,989,625 - 17,091,096 (+)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1517,070,557 - 17,171,948 (+)NCBIHuRef
CHM1_11540,345,953 - 40,447,471 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EIF2AK4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322904
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.