PIPOX (pipecolic acid and sarcosine oxidase) - Rat Genome Database
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Gene: PIPOX (pipecolic acid and sarcosine oxidase) Homo sapiens
Analyze
Symbol: PIPOX
Name: pipecolic acid and sarcosine oxidase
RGD ID: 1322755
Description: Exhibits L-pipecolate oxidase activity and sarcosine oxidase activity. Involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate and oxidation-reduction process. Localizes to peroxisome; PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; hyperlysinemia pathway; INTERACTS WITH 1-piperideine-6-carboxylic acid; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-pipecolate oxidase; L-pipecolic acid oxidase; LPIPOX; peroxisomal sarcosine oxidase; pipecolic acid oxidase; PSO
Orthologs:
Mus musculus (house mouse) : Pipox (pipecolic acid oxidase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pipox (pipecolic acid and sarcosine oxidase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pipox (pipecolic acid and sarcosine oxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : PIPOX (pipecolic acid and sarcosine oxidase)
Canis lupus familiaris (dog) : PIPOX (pipecolic acid and sarcosine oxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pipox (pipecolic acid and sarcosine oxidase)
Sus scrofa (pig) : LOC110255229 (peroxisomal sarcosine oxidase)
Chlorocebus sabaeus (African green monkey) : PIPOX (pipecolic acid and sarcosine oxidase)
Heterocephalus glaber (naked mole-rat) : Pipox (pipecolic acid and sarcosine oxidase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1728,950,513 - 29,057,216 (+)EnsemblGRCh38hg38GRCh38
GRCh381729,043,141 - 29,057,227 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,369,918 - 27,384,245 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,394,044 - 24,408,362 (+)NCBINCBI36hg18NCBI36
Build 341724,394,043 - 24,408,362NCBI
Celera1724,229,276 - 24,243,594 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,578,154 - 23,592,473 (+)NCBIHuRef
CHM1_11727,432,423 - 27,446,741 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (TAS)
peroxisomal matrix  (TAS)
peroxisome  (IBA,IDA)

Molecular Function

References

Additional References at PubMed
PMID:10642506   PMID:10772957   PMID:10931946   PMID:11330064   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16169070   PMID:20178365   PMID:20634891   PMID:21044950   PMID:21873635  
PMID:26186194   PMID:28514442  


Genomics

Comparative Map Data
PIPOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1728,950,513 - 29,057,216 (+)EnsemblGRCh38hg38GRCh38
GRCh381729,043,141 - 29,057,227 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371727,369,918 - 27,384,245 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,394,044 - 24,408,362 (+)NCBINCBI36hg18NCBI36
Build 341724,394,043 - 24,408,362NCBI
Celera1724,229,276 - 24,243,594 (+)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1723,578,154 - 23,592,473 (+)NCBIHuRef
CHM1_11727,432,423 - 27,446,741 (+)NCBICHM1_1
Pipox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391177,771,440 - 77,784,698 (-)NCBI
GRCm381177,880,614 - 77,893,872 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,880,615 - 77,894,096 (-)EnsemblGRCm38mm10GRCm38
MGSCv371177,694,117 - 77,707,374 (-)NCBIGRCm37mm9NCBIm37
MGSCv361177,696,810 - 77,709,979 (-)NCBImm8
Celera1185,380,241 - 85,393,553 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Pipox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01064,951,986 - 64,964,865 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,952,119 - 64,964,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,660,848 - 66,673,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,920,814 - 63,933,307 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11063,934,437 - 63,946,930 (-)NCBI
Celera1061,749,538 - 61,762,034 (-)NCBICelera
Cytogenetic Map10q25NCBI
Pipox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,128,509 - 4,143,334 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,128,503 - 4,225,027 (-)NCBIChiLan1.0ChiLan1.0
PIPOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11728,225,831 - 28,240,210 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,225,831 - 28,240,210 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01727,717,083 - 27,820,776 (-)NCBIMhudiblu_PPA_v0panPan3
PIPOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl943,200,371 - 43,212,288 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1943,200,343 - 43,212,288 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pipox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365385,218,097 - 5,252,579 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110255229
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1245,257,188 - 45,322,767 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11245,256,806 - 45,270,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PIPOX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1622,805,740 - 22,820,537 (+)Ensembl
ChlSab1.11622,805,369 - 22,820,015 (+)NCBI
Pipox
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247861,594,988 - 1,615,210 (+)NCBI

Position Markers
RH67627  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,383,981 - 27,384,116UniSTSGRCh37
GRCh3710118,089,093 - 118,090,284UniSTSGRCh37
Build 361724,408,107 - 24,408,242RGDNCBI36
Celera10111,818,302 - 111,819,493UniSTS
Celera1724,243,339 - 24,243,474RGD
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map17q11.2UniSTS
HuRef10111,716,166 - 111,717,357UniSTS
HuRef1723,592,218 - 23,592,353UniSTS
RH36300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,384,063 - 27,384,166UniSTSGRCh37
Build 361724,408,189 - 24,408,292RGDNCBI36
Celera1724,243,421 - 24,243,524RGD
Cytogenetic Map17q11.2UniSTS
HuRef1723,592,300 - 23,592,403UniSTS
G38154  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q12UniSTS
Cytogenetic Map3q26.1UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map20q11.2-q13.2UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map5q11.2UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map2q37UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map3p21.1UniSTS
G32936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371727,383,981 - 27,384,116UniSTSGRCh37
Celera1724,243,339 - 24,243,474UniSTS
Cytogenetic Map17q11.2UniSTS
HuRef1723,592,218 - 23,592,353UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR197hsa-miR-197-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16822819

Predicted Target Of
Summary Value
Count of predictions:2707
Count of miRNA genes:989
Interacting mature miRNAs:1207
Transcripts:ENST00000323372, ENST00000419875, ENST00000466889, ENST00000469082, ENST00000484308, ENST00000577182, ENST00000578748, ENST00000580241, ENST00000580383, ENST00000583215
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 65 6 421 421 13 421 182 8 237 135 60 39 1
Low 1949 1573 549 69 1235 34 2633 973 3248 195 1201 784 43 511 1757 2
Below cutoff 417 1392 751 132 691 9 1533 1202 233 89 183 779 128 691 1029 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000323372   ⟹   ENSP00000317721
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1729,043,141 - 29,057,216 (+)Ensembl
RefSeq Acc Id: ENST00000419875
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1729,051,956 - 29,053,660 (+)Ensembl
RefSeq Acc Id: ENST00000466889   ⟹   ENSP00000465428
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1729,044,218 - 29,053,592 (+)Ensembl
RefSeq Acc Id: ENST00000469082   ⟹   ENSP00000465329
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1729,044,251 - 29,055,067 (+)Ensembl
RefSeq Acc Id: ENST00000484308
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1729,046,640 - 29,056,225 (+)Ensembl
RefSeq Acc Id: ENST00000577182
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,952,439 - 29,053,133 (+)Ensembl
RefSeq Acc Id: ENST00000578748
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,951,860 - 29,045,007 (+)Ensembl
RefSeq Acc Id: ENST00000580241
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,950,513 - 29,056,683 (+)Ensembl
RefSeq Acc Id: ENST00000580383
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,950,620 - 29,053,446 (+)Ensembl
RefSeq Acc Id: ENST00000583215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1728,950,643 - 29,056,683 (+)Ensembl
RefSeq Acc Id: NM_016518   ⟹   NP_057602
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381729,043,141 - 29,057,216 (+)NCBI
GRCh371727,369,918 - 27,384,245 (+)NCBI
Build 361724,394,044 - 24,408,362 (+)NCBI Archive
Celera1724,229,276 - 24,243,594 (+)RGD
HuRef1723,578,154 - 23,592,473 (+)ENTREZGENE
CHM1_11727,432,423 - 27,446,741 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017024722   ⟹   XP_016880211
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381729,046,660 - 29,057,227 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057602   ⟸   NM_016518
- UniProtKB: Q9P0Z9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016880211   ⟸   XM_017024722
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000465428   ⟸   ENST00000466889
RefSeq Acc Id: ENSP00000317721   ⟸   ENST00000323372
RefSeq Acc Id: ENSP00000465329   ⟸   ENST00000469082
Protein Domains
DAO

Promoters
RGD ID:7234463
Promoter ID:EPDNEW_H22977
Type:initiation region
Name:PIPOX_1
Description:pipecolic acid and sarcosine oxidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381729,043,182 - 29,043,242EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q11.2(chr17:28757283-29216419)x3 copy number gain See cases [RCV000142450] Chr17:28757283..29216419 [GRCh38]
Chr17:27084301..27543437 [GRCh37]
Chr17:24108428..24567563 [NCBI36]
Chr17:17q11.2
uncertain significance
GRCh38/hg38 17q11.2(chr17:28947825-32490020)x1 copy number loss See cases [RCV000143027] Chr17:28947825..32490020 [GRCh38]
Chr17:27274843..30817038 [GRCh37]
Chr17:24298969..27841151 [NCBI36]
Chr17:17q11.2
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25403446-31685464)x3 copy number gain not provided [RCV000762776] Chr17:25403446..31685464 [GRCh37]
Chr17:17q11.1-11.2
likely pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25248166-30645676)x1 copy number loss MEK Inhibitor response [RCV000626439] Chr17:25248166..30645676 [GRCh37]
Chr17:17q11.1-11.2
drug response
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p11.2-q11.2(chr17:21279289-27474974)x2 copy number gain not provided [RCV000739439] Chr17:21279289..27474974 [GRCh37]
Chr17:17p11.2-q11.2
likely pathogenic
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q11.1-11.2(chr17:25274363-28450707)x3 copy number gain not provided [RCV001006886] Chr17:25274363..28450707 [GRCh37]
Chr17:17q11.1-11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17804 AgrOrtholog
COSMIC PIPOX COSMIC
Ensembl Genes ENSG00000179761 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000317721 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465329 UniProtKB/TrEMBL
  ENSP00000465428 UniProtKB/TrEMBL
Ensembl Transcript ENST00000323372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000466889 UniProtKB/TrEMBL
  ENST00000469082 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000179761 GTEx
HGNC ID HGNC:17804 ENTREZGENE
Human Proteome Map PIPOX Human Proteome Map
InterPro FAD-dep_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SoxA_mon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51268 UniProtKB/Swiss-Prot
NCBI Gene 51268 ENTREZGENE
OMIM 616713 OMIM
Pfam DAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33332 PharmGKB
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs soxA_mon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.462585 ENTREZGENE
UniProt K7EJU8_HUMAN UniProtKB/TrEMBL
  K7EK30_HUMAN UniProtKB/TrEMBL
  Q6IAJ9_HUMAN UniProtKB/TrEMBL
  Q8N6Z6_HUMAN UniProtKB/TrEMBL
  Q9P0Z9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B3KNH0 UniProtKB/Swiss-Prot
  Q96H28 UniProtKB/Swiss-Prot
  Q9C070 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 PIPOX  pipecolic acid and sarcosine oxidase    pipecolic acid oxidase  Symbol and/or name change 5135510 APPROVED