Nckipsd (NCK interacting protein with SH3 domain) - Rat Genome Database
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Gene: Nckipsd (NCK interacting protein with SH3 domain) Mus musculus
Analyze
Symbol: Nckipsd
Name: NCK interacting protein with SH3 domain
RGD ID: 1322715
MGI Page MGI
Description: Predicted to have SH3 domain binding activity. Involved in positive regulation of neuron projection development. Predicted to colocalize with COP9 signalosome. Is expressed in central nervous system and retina. Orthologous to human NCKIPSD (NCK interacting protein with SH3 domain); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 54 kDa VacA-interacting protein; 90 kDa N-WASP-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3P; AF3P21; DI; DIP1; mDia interacting protein-1; N-WASP-binding protein; NCK-interacting protein with SH3 domain; ORF1; SH3 adapter protein SPIN90; SP; SPIN90; VIP54; Wa; Wasbp; WASLBP; WASP-interacting SH3-domain protein; WI; WISH; Wiskott-Aldrich syndrome homolog binding protein; wiskott-Aldrich syndrome protein-binding protein WISH
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,685,515 - 108,696,038 (+)NCBIGRCm39mm39
GRCm389108,808,346 - 108,818,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,808,368 - 108,818,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,710,711 - 108,720,697 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,665,603 - 108,675,589 (+)NCBImm8
Celera9108,415,507 - 108,425,522 (+)NCBICelera
Cytogenetic Map9F2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10619843   PMID:11042159   PMID:11076861   PMID:11157975   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16221862   PMID:16602821   PMID:18234668   PMID:19302483   PMID:19778379   PMID:20697350   PMID:21267068   PMID:21763308   PMID:22018352   PMID:23342115   PMID:24965518  
PMID:28340616   PMID:28652253   PMID:30341913  


Genomics

Comparative Map Data
Nckipsd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,685,515 - 108,696,038 (+)NCBIGRCm39mm39
GRCm389108,808,346 - 108,818,839 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,808,368 - 108,818,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,710,711 - 108,720,697 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,665,603 - 108,675,589 (+)NCBImm8
Celera9108,415,507 - 108,425,522 (+)NCBICelera
Cytogenetic Map9F2NCBI
NCKIPSD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,673,844 - 48,686,364 (-)EnsemblGRCh38hg38GRCh38
GRCh38348,663,814 - 48,685,941 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,700,419 - 48,723,366 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,686,281 - 48,698,338 (-)NCBINCBI36hg18NCBI36
Build 34348,686,283 - 48,698,338NCBI
Celera348,667,186 - 48,679,261 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,769,232 - 48,781,781 (-)NCBIHuRef
CHM1_1348,663,370 - 48,675,464 (-)NCBICHM1_1
Nckipsd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08117,601,035 - 117,612,302 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,600,749 - 117,611,922 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,946,218 - 116,957,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,863,906 - 113,873,968 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,883,284 - 113,893,428 (+)NCBI
Celera8108,806,304 - 108,816,365 (+)NCBICelera
Cytogenetic Map8q32NCBI
Nckipsd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532755,997 - 764,855 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532755,997 - 766,202 (-)NCBIChiLan1.0ChiLan1.0
NCKIPSD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1349,676,282 - 49,690,035 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,676,282 - 49,688,548 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0348,586,112 - 48,606,811 (-)NCBIMhudiblu_PPA_v0panPan3
NCKIPSD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2040,442,386 - 40,449,542 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12040,443,245 - 40,449,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nckipsd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936529474,978 - 485,333 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCKIPSD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,363,748 - 31,377,684 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,366,574 - 31,377,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,637,511 - 34,644,922 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCKIPSD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,083,042 - 10,095,654 (-)NCBI
ChlSab1.1 Ensembl2210,081,218 - 10,095,566 (-)Ensembl
Nckipsd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,685,256 - 2,695,387 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:234
Interacting mature miRNAs:272
Transcripts:ENSMUST00000035218
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035218   ⟹   ENSMUSP00000035218
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,808,368 - 108,818,844 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192180
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,814,836 - 108,816,121 (+)Ensembl
RefSeq Acc Id: ENSMUST00000192678   ⟹   ENSMUSP00000141857
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,811,925 - 108,814,081 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194413
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,813,428 - 108,814,326 (+)Ensembl
RefSeq Acc Id: ENSMUST00000194819   ⟹   ENSMUSP00000141702
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,808,421 - 108,811,605 (+)Ensembl
RefSeq Acc Id: ENSMUST00000195323   ⟹   ENSMUSP00000141728
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,808,373 - 108,811,149 (+)Ensembl
RefSeq Acc Id: NM_030729   ⟹   NP_109654
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,685,579 - 108,695,565 (+)NCBI
GRCm389108,808,380 - 108,818,366 (+)NCBI
MGSCv379108,710,711 - 108,720,697 (+)RGD
Celera9108,415,507 - 108,425,522 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511860   ⟹   XP_006511923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,685,561 - 108,696,038 (+)NCBI
GRCm389108,808,373 - 108,818,839 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244729   ⟹   XP_030100589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,690,018 - 108,696,038 (+)NCBI
GRCm389108,808,369 - 108,818,839 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003948066
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,685,515 - 108,696,038 (+)NCBI
GRCm389108,808,346 - 108,818,026 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004935611
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399108,685,515 - 108,691,945 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_109654   ⟸   NM_030729
- UniProtKB: Q9ESJ4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511923   ⟸   XM_006511860
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030100589   ⟸   XM_030244729
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000141857   ⟸   ENSMUST00000192678
RefSeq Acc Id: ENSMUSP00000035218   ⟸   ENSMUST00000035218
RefSeq Acc Id: ENSMUSP00000141728   ⟸   ENSMUST00000195323
RefSeq Acc Id: ENSMUSP00000141702   ⟸   ENSMUST00000194819
Protein Domains
SH3

Promoters
RGD ID:6844865
Promoter ID:MM_KWN:58825
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000035218
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,710,176 - 108,710,847 (+)MPROMDB
RGD ID:6848433
Promoter ID:MM_ACW:52065
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NCKIPSD.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369108,717,331 - 108,717,831 (+)MPROMDB
RGD ID:8670932
Promoter ID:EPDNEW_M13497
Type:initiation region
Name:Nckipsd_1
Description:Mus musculus NCK interacting protein with SH3 domain , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,808,402 - 108,808,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931834 AgrOrtholog
Ensembl Genes ENSMUSG00000032598 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000107055 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035218 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141702 UniProtKB/TrEMBL
  ENSMUSP00000141728 UniProtKB/TrEMBL
  ENSMUSP00000141857 UniProtKB/TrEMBL
  ENSMUSP00000144069 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035218 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000192678 UniProtKB/TrEMBL
  ENSMUST00000194819 UniProtKB/TrEMBL
  ENSMUST00000195323 UniProtKB/TrEMBL
  ENSMUST00000202637 UniProtKB/Swiss-Prot
InterPro DUF2013 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPIN90_SH3 UniProtKB/Swiss-Prot
KEGG Report mmu:80987 UniProtKB/Swiss-Prot
MGD MGI:1931834 ENTREZGENE
NCBI Gene 80987 ENTREZGENE
Pfam DUF2013 UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nckipsd PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.192416 ENTREZGENE
UniProt A0A0A6YWU4_MOUSE UniProtKB/TrEMBL
  A0A0A6YWW3_MOUSE UniProtKB/TrEMBL
  A0A0A6YX64_MOUSE UniProtKB/TrEMBL
  Q9ESJ4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3UYF3 UniProtKB/Swiss-Prot
  Q68G72 UniProtKB/Swiss-Prot