Slc25a16 (solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16) - Rat Genome Database

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Gene: Slc25a16 (solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16) Mus musculus
Analyze
Symbol: Slc25a16
Name: solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
RGD ID: 1322698
MGI Page MGI
Description: Predicted to enable coenzyme A transmembrane transporter activity and secondary active transmembrane transporter activity. Predicted to be involved in coenzyme A biosynthetic process and mitochondrial coenzyme A transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A16 (solute carrier family 25 member 16).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3110021G18Rik; GDA; GDC; graves disease carrier protein homolog; HGT.1; mitochondrial solute carrier protein homolog; ML; ML7; solute carrier family 25 member 16
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,756,454 - 62,782,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,756,412 - 62,782,277 (+)EnsemblGRCm39 Ensembl
GRCm381062,920,632 - 62,946,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,920,633 - 62,946,498 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,383,381 - 62,409,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,315,990 - 62,341,851 (+)NCBIMGSCv36mm8
Celera1064,021,749 - 64,047,627 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11158296   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:18614015   PMID:18799693   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Slc25a16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,756,454 - 62,782,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,756,412 - 62,782,277 (+)EnsemblGRCm39 Ensembl
GRCm381062,920,632 - 62,946,494 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,920,633 - 62,946,498 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,383,381 - 62,409,242 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,315,990 - 62,341,851 (+)NCBIMGSCv36mm8
Celera1064,021,749 - 64,047,627 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.5NCBI
SLC25A16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381068,477,998 - 68,527,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1068,477,998 - 68,527,523 (-)EnsemblGRCh38hg38GRCh38
GRCh371070,237,755 - 70,287,280 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,912,103 - 69,957,590 (-)NCBINCBI36Build 36hg18NCBI36
Build 341069,912,103 - 69,957,590NCBI
Celera1063,517,479 - 63,563,049 (-)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1064,241,842 - 64,288,560 (-)NCBIHuRef
CHM1_11070,524,338 - 70,569,332 (-)NCBICHM1_1
T2T-CHM13v2.01069,347,236 - 69,396,739 (-)NCBIT2T-CHM13v2.0
Slc25a16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,659,847 - 25,717,080 (-)NCBIGRCr8
mRatBN7.22025,691,474 - 25,717,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,662,055 - 25,716,319 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,385,022 - 26,409,844 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,738,050 - 25,762,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02026,324,094 - 26,348,852 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02027,283,383 - 27,308,069 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,254,984 - 27,308,069 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02029,124,026 - 29,147,931 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,259,020 - 25,287,344 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,272,066 - 25,299,061 (+)NCBI
Celera2026,987,115 - 27,012,429 (-)NCBICelera
Cytogenetic Map20q11NCBI
Slc25a16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,707,006 - 20,739,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,705,758 - 20,739,692 (-)NCBIChiLan1.0ChiLan1.0
SLC25A16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,695,305 - 19,738,832 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,697,034 - 19,738,834 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,826,297 - 19,870,093 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,966,484 - 20,010,542 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,967,641 - 20,010,559 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,868,192 - 19,911,728 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,071,276 - 20,114,631 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0420,413,440 - 20,457,128 (-)NCBIUU_Cfam_GSD_1.0
Slc25a16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,300,357 - 61,340,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365219,793,038 - 9,834,973 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365219,793,088 - 9,834,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,610,475 - 71,651,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,612,273 - 71,651,341 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,648,575 - 77,715,804 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,871,828 - 62,926,759 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604823,629,311 - 23,675,003 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,800,350 - 2,837,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,800,432 - 2,837,910 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a16
684 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:818
Count of miRNA genes:490
Interacting mature miRNAs:560
Transcripts:ENSMUST00000044977, ENSMUST00000138597, ENSMUST00000144459, ENSMUST00000152350
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
38455999Lick3_mlick rate 3 (mouse)106187303169373082Mouse

Markers in Region
Slc25a16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B4UniSTS
cM Map1032.5UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000044977   ⟹   ENSMUSP00000043370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1062,756,412 - 62,782,277 (+)Ensembl
GRCm38.p6 Ensembl1062,920,633 - 62,946,498 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138597
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1062,756,446 - 62,765,603 (+)Ensembl
GRCm38.p6 Ensembl1062,920,667 - 62,929,824 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144459   ⟹   ENSMUSP00000114510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1062,756,459 - 62,780,208 (+)Ensembl
GRCm38.p6 Ensembl1062,920,680 - 62,944,429 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152350
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1062,778,221 - 62,780,213 (+)Ensembl
GRCm38.p6 Ensembl1062,942,442 - 62,944,434 (+)Ensembl
RefSeq Acc Id: NM_001417857   ⟹   NP_001404786
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391062,756,454 - 62,782,278 (+)NCBI
RefSeq Acc Id: NM_175194   ⟹   NP_780403
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391062,756,454 - 62,782,278 (+)NCBI
GRCm381062,920,633 - 62,946,494 (+)NCBI
MGSCv371062,383,381 - 62,409,242 (+)RGD
Celera1064,021,749 - 64,047,627 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780403   ⟸   NM_175194
- Peptide Label: isoform 1
- UniProtKB: B2RSS4 (UniProtKB/Swiss-Prot),   Q6P6K8 (UniProtKB/Swiss-Prot),   Q8C0K5 (UniProtKB/Swiss-Prot),   D3YVC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114510   ⟸   ENSMUST00000144459
RefSeq Acc Id: ENSMUSP00000043370   ⟸   ENSMUST00000044977
RefSeq Acc Id: NP_001404786   ⟸   NM_001417857
- Peptide Label: isoform 2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C0K5-F1-model_v2 AlphaFold Q8C0K5 1-332 view protein structure

Promoters
RGD ID:6819928
Promoter ID:MM_KWN:4346
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000076230,   OTTMUST00000076232,   UC007FJG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361062,383,041 - 62,383,541 (+)MPROMDB
RGD ID:8672156
Promoter ID:EPDNEW_M14108
Type:initiation region
Name:Slc25a16_1
Description:Mus musculus solute carrier family 25 (mitochondrial carrier,Graves disease autoantigen), member 16 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381062,920,675 - 62,920,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920382 AgrOrtholog
Ensembl Genes ENSMUSG00000071253 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044977 ENTREZGENE
  ENSMUST00000044977.10 UniProtKB/Swiss-Prot
  ENSMUST00000144459.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Graves_DC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73132 UniProtKB/Swiss-Prot
MGD MGI:1920382 ENTREZGENE
NCBI Gene 73132 ENTREZGENE
PANTHER GRAVES DISEASE CARRIER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc25a16 PhenoGen
PRINTS GRAVESDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCARRIER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RSS4 ENTREZGENE
  D3YVC9 ENTREZGENE, UniProtKB/TrEMBL
  GDC_MOUSE UniProtKB/Swiss-Prot
  Q6P6K8 ENTREZGENE
  Q8C0K5 ENTREZGENE
UniProt Secondary B2RSS4 UniProtKB/Swiss-Prot
  Q6P6K8 UniProtKB/Swiss-Prot