TSPYL5 (TSPY like 5) - Rat Genome Database

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Gene: TSPYL5 (TSPY like 5) Homo sapiens
Analyze
Symbol: TSPYL5
Name: TSPY like 5
RGD ID: 1322624
HGNC Page HGNC
Description: Predicted to have chromatin binding activity and histone binding activity. Involved in several processes, including cellular response to gamma radiation; positive regulation of protein kinase B signaling; and positive regulation of protein ubiquitination. Predicted to localize to nucleus; INTERACTS WITH afimoxifene; aflatoxin B1; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: KIAA1750; testis-specific Y-encoded-like protein 5; TSPY-like 5; TSPY-like protein 5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: TSPY26P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl897,273,488 - 97,277,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38897,273,488 - 97,277,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37898,285,716 - 98,290,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36898,354,890 - 98,359,352 (-)NCBINCBI36hg18NCBI36
Build 34898,354,890 - 98,359,352NCBI
Celera894,471,979 - 94,476,441 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef893,492,162 - 93,496,624 (-)NCBIHuRef
CHM1_1898,326,220 - 98,330,682 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleus  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:11214970   PMID:14702039   PMID:17207965   PMID:18059362   PMID:20079711   PMID:21170034   PMID:21873635   PMID:23518928   PMID:26386860   PMID:26911678   PMID:28196872   PMID:28235398  
PMID:28847364   PMID:28972400   PMID:29240449   PMID:29509190   PMID:29748603   PMID:30232004   PMID:30471052   PMID:31048545   PMID:31278054  


Genomics

Comparative Map Data
TSPYL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl897,273,488 - 97,277,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38897,273,488 - 97,277,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37898,285,716 - 98,290,156 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36898,354,890 - 98,359,352 (-)NCBINCBI36hg18NCBI36
Build 34898,354,890 - 98,359,352NCBI
Celera894,471,979 - 94,476,441 (-)NCBI
Cytogenetic Map8q22.1NCBI
HuRef893,492,162 - 93,496,624 (-)NCBIHuRef
CHM1_1898,326,220 - 98,330,682 (-)NCBICHM1_1
Tspyl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391533,684,021 - 33,688,029 (-)NCBIGRCm39mm39
GRCm39 Ensembl1533,684,021 - 33,688,030 (-)Ensembl
GRCm381533,683,875 - 33,687,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1533,683,875 - 33,687,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv371533,613,630 - 33,617,638 (-)NCBIGRCm37mm9NCBIm37
MGSCv361533,628,464 - 33,632,438 (-)NCBImm8
Celera1534,331,686 - 34,335,694 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Tspyl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2764,881,092 - 64,885,538 (-)NCBI
Rnor_6.0 Ensembl772,326,896 - 72,328,128 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0772,323,764 - 72,328,228 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0772,494,474 - 72,498,910 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4769,061,484 - 69,063,175 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1769,082,672 - 69,096,515 (-)NCBI
Celera762,000,700 - 62,005,164 (-)NCBICelera
Cytogenetic Map7q22NCBI
Tspyl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541713,135,178 - 13,136,413 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541713,133,655 - 13,136,768 (-)NCBIChiLan1.0ChiLan1.0
TSPYL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1896,107,774 - 96,112,254 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0893,573,775 - 93,918,775 (-)NCBIMhudiblu_PPA_v0panPan3
TSPYL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12941,500,395 - 41,503,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2941,503,312 - 41,503,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02941,694,456 - 41,698,042 (-)NCBI
UMICH_Zoey_3.12941,733,965 - 41,737,553 (-)NCBI
UNSW_CanFamBas_1.02941,703,848 - 41,707,446 (-)NCBI
UU_Cfam_GSD_1.02942,168,839 - 42,172,437 (-)NCBI
Tspyl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530337,959,029 - 37,984,221 (+)NCBI
SpeTri2.0NW_00493647045,385,155 - 45,410,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPYL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl439,362,962 - 39,369,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1439,362,945 - 39,367,405 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TSPYL5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1892,217,919 - 92,222,373 (-)NCBI
ChlSab1.1 Ensembl892,221,034 - 92,222,287 (-)Ensembl
Tspyl5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247634,564,966 - 4,569,495 (-)NCBI

Position Markers
RH12019  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,285,740 - 98,285,873UniSTSGRCh37
Build 36898,354,916 - 98,355,049RGDNCBI36
Celera894,472,005 - 94,472,138RGD
Cytogenetic Map8q22.1UniSTS
HuRef893,492,188 - 93,492,321UniSTS
GeneMap99-GB4 RH Map8440.32UniSTS
NCBI RH Map81214.5UniSTS
STS-AA033739  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,286,538 - 98,286,751UniSTSGRCh37
Build 36898,355,714 - 98,355,927RGDNCBI36
Celera894,472,803 - 94,473,016RGD
Cytogenetic Map8q22.1UniSTS
HuRef893,492,986 - 93,493,199UniSTS
GeneMap99-GB4 RH Map8445.79UniSTS
SHGC-32191  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,285,733 - 98,285,857UniSTSGRCh37
Build 36898,354,909 - 98,355,033RGDNCBI36
Celera894,471,998 - 94,472,122RGD
Cytogenetic Map8q22.1UniSTS
HuRef893,492,181 - 93,492,305UniSTS
GeneMap99-GB4 RH Map8438.49UniSTS
Whitehead-RH Map8579.4UniSTS
NCBI RH Map81214.5UniSTS
AB050517  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37898,285,719 - 98,285,869UniSTSGRCh37
Build 36898,354,895 - 98,355,045RGDNCBI36
Celera894,471,984 - 94,472,134RGD
HuRef893,492,167 - 93,492,317UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1416
Count of miRNA genes:756
Interacting mature miRNAs:870
Transcripts:ENST00000322128
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1425 1419 946 98 390 22 1959 892 2550 177 1210 911 81 1 429 1388 2 1
Low 897 959 653 404 769 319 2312 1285 1137 212 176 633 86 775 1400 2 1
Below cutoff 23 608 108 107 661 107 21 10 5 5 23 15 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000322128   ⟹   ENSP00000322802
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl897,273,488 - 97,277,928 (-)Ensembl
RefSeq Acc Id: NM_033512   ⟹   NP_277047
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38897,273,488 - 97,277,928 (-)NCBI
GRCh37898,285,714 - 98,290,192 (-)NCBI
Build 36898,354,890 - 98,359,352 (-)NCBI Archive
Celera894,471,979 - 94,476,441 (-)RGD
HuRef893,492,162 - 93,496,624 (-)RGD
CHM1_1898,326,220 - 98,330,682 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_277047 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH45630 (Get FASTA)   NCBI Sequence Viewer  
  BAB21841 (Get FASTA)   NCBI Sequence Viewer  
  BAG52362 (Get FASTA)   NCBI Sequence Viewer  
  EAW91759 (Get FASTA)   NCBI Sequence Viewer  
  Q86VY4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_277047   ⟸   NM_033512
- UniProtKB: Q86VY4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000322802   ⟸   ENST00000322128


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1(chr8:92755532-97792132)x1 copy number loss See cases [RCV000054278] Chr8:92755532..97792132 [GRCh38]
Chr8:93767760..98804360 [GRCh37]
Chr8:93836936..98873536 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q22.1(chr8:96065893-97276981)x1 copy number loss See cases [RCV000054279] Chr8:96065893..97276981 [GRCh38]
Chr8:97078121..98289209 [GRCh37]
Chr8:97147297..98358385 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8q22.1(chr8:96468763-98522743)x1 copy number loss not provided [RCV000683017] Chr8:96468763..98522743 [GRCh37]
Chr8:8q22.1
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_033512.3(TSPYL5):c.407C>T (p.Pro136Leu) single nucleotide variant not provided [RCV000964486] Chr8:97277438 [GRCh38]
Chr8:98289666 [GRCh37]
Chr8:8q22.1
likely benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:96646399-98973327)x3 copy number gain not provided [RCV001006122] Chr8:96646399..98973327 [GRCh37]
Chr8:8q22.1
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29367 AgrOrtholog
COSMIC TSPYL5 COSMIC
Ensembl Genes ENSG00000180543 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000322802 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000322128 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000180543 GTEx
HGNC ID HGNC:29367 ENTREZGENE
Human Proteome Map TSPYL5 Human Proteome Map
InterPro NAP-like_sf UniProtKB/Swiss-Prot
  NAP_family UniProtKB/Swiss-Prot
KEGG Report hsa:85453 UniProtKB/Swiss-Prot
NCBI Gene 85453 ENTREZGENE
OMIM 614721 OMIM
PANTHER PTHR11875 UniProtKB/Swiss-Prot
Pfam NAP UniProtKB/Swiss-Prot
PharmGKB PA128394738 PharmGKB
Superfamily-SCOP SSF143113 UniProtKB/Swiss-Prot
UniProt Q86VY4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B3KRF0 UniProtKB/Swiss-Prot
  Q9C0B3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 TSPYL5  TSPY like 5    TSPY-like 5  Symbol and/or name change 5135510 APPROVED