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Gene: SH3PXD2A (SH3 and PX domains 2A) Homo sapiens
Symbol: SH3PXD2A
Name: SH3 and PX domains 2A
Description: Predicted to have phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Localizes to podosome; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adapter protein TKS5; adaptor protein TKS5; FISH; five SH3 domain-containing protein; five SH3 domains; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; SH3MD1; TKS5; TSK5; tyrosine kinase substrate with five SH3 domains
Mus musculus (house mouse) : Sh3pxd2a (SH3 and PX domains 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh3pxd2a (SH3 and PX domains 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3pxd2a (SH3 and PX domains 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3PXD2A (SH3 and PX domains 2A)
Canis lupus familiaris (dog) : SH3PXD2A (SH3 and PX domains 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3pxd2a (SH3 and PX domains 2A)
Sus scrofa (pig) : SH3PXD2A (SH3 and PX domains 2A)
Chlorocebus sabaeus (African green monkey) : SH3PXD2A (SH3 and PX domains 2A)
Heterocephalus glaber (naked mole-rat) : Sh3pxd2a (SH3 and PX domains 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10103,594,027 - 103,855,543 (-)EnsemblGRCh38hg38GRCh38
GRCh3810103,594,027 - 103,855,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710105,353,784 - 105,615,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610105,343,774 - 105,605,154 (-)NCBINCBI36hg18NCBI36
Build 3410105,343,773 - 105,605,154NCBI
Celera1099,093,721 - 99,355,050 (-)NCBI
Cytogenetic Map10q24.33NCBI
HuRef1098,984,423 - 99,246,081 (-)NCBIHuRef
CHM1_110105,637,905 - 105,898,918 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SH3PXD2A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322510
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.