Brf1 (BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit) - Rat Genome Database

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Gene: Brf1 (BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit) Mus musculus
Analyze
Symbol: Brf1
Name: BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
RGD ID: 1322468
MGI Page MGI
Description: Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within regulation of mRNA stability. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2510002F24Rik; B-related factor 1; BRF-1; BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB; GTF3B; hTFIIIB90; mTFIIIB90; TAF3; TAF3C; TAFI; TAFIII90; TFIII; TFIIIB90; transcription factor IIIB 90 kDa subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,919,251 - 112,964,327 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,923,705 - 112,964,324 (-)EnsemblGRCm39 Ensembl
GRCm3812112,955,631 - 113,000,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,960,085 - 113,000,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,198,073 - 114,238,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,407,670 - 113,448,429 (-)NCBIMGSCv36mm8
Celera12114,169,891 - 114,214,927 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, etal., Circ Res. 2008 May 23;102(10):1222-9. doi: 10.1161/CIRCRESAHA.107.163550. Epub 2008 Apr 17.
2. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, etal., Cell Cycle. 2010 Sep 15;9(18):3687-99. Epub 2010 Sep 1.
3. Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. Johnson SA, etal., J Biol Chem. 2008 Jul 11;283(28):19184-91. doi: 10.1074/jbc.M802872200. Epub 2008 May 1.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):258-64. doi: 10.1016/j.bbagrm.2012.09.009. Epub 2012 Sep 29.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14976220   PMID:15489334   PMID:15741177   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:17030608   PMID:21106530   PMID:21677750   PMID:21873635   PMID:24733888   PMID:30858608  


Genomics

Comparative Map Data
Brf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,919,251 - 112,964,327 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,923,705 - 112,964,324 (-)EnsemblGRCm39 Ensembl
GRCm3812112,955,631 - 113,000,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,960,085 - 113,000,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,198,073 - 114,238,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,407,670 - 113,448,429 (-)NCBIMGSCv36mm8
Celera12114,169,891 - 114,214,927 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.47NCBI
BRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,209,286 - 105,315,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,209,286 - 105,315,589 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,675,623 - 105,781,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,746,668 - 104,838,374 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,746,669 - 104,785,813NCBI
Celera1485,728,231 - 85,815,347 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,867,702 - 85,977,984 (-)NCBIHuRef
CHM1_114105,613,624 - 105,719,675 (-)NCBICHM1_1
T2T-CHM13v2.01499,451,085 - 99,562,978 (-)NCBIT2T-CHM13v2.0
Brf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,854,055 - 137,902,629 (-)NCBIGRCr8
mRatBN7.26132,034,378 - 132,081,313 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6132,037,272 - 132,081,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,203,931 - 132,250,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,493,755 - 132,540,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,868,689 - 131,915,747 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,762,230 - 137,808,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,765,122 - 137,808,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,758,410 - 146,804,495 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,962,953 - 138,007,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,969,414 - 138,013,785 (-)NCBI
Celera6129,575,149 - 129,619,238 (-)NCBICelera
Cytogenetic Map6q32NCBI
Brf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555383,470,249 - 3,544,704 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555383,469,322 - 3,544,704 (-)NCBIChiLan1.0ChiLan1.0
BRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,388,380 - 106,487,436 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,604,882 - 105,703,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,851,908 - 85,950,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,635,757 - 105,714,465 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,635,757 - 105,714,465 (-)Ensemblpanpan1.1panPan2
BRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,588,578 - 72,632,259 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,588,693 - 72,632,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha872,099,839 - 72,151,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,875,602 - 72,927,645 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,875,602 - 72,927,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,556,286 - 72,608,091 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,607,209 - 72,658,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,997,125 - 73,048,881 (-)NCBIUU_Cfam_GSD_1.0
Brf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,436,877 - 1,500,298 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621265,829 - 328,040 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621265,834 - 329,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,386,132 - 131,389,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12483,117,823 - 83,192,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2483,117,685 - 83,192,431 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,562,181 - 70,642,058 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734213,895 - 279,777 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734213,536 - 280,816 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brf1
1162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:242
Interacting mature miRNAs:262
Transcripts:ENSMUST00000011302
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse

Markers in Region
AW822243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812112,971,836 - 112,972,093UniSTSGRCm38
MGSCv3712114,210,047 - 114,210,304UniSTSGRCm37
Celera12114,181,865 - 114,182,122UniSTS
Cytogenetic Map12F1UniSTS
Whitehead/MRC_RH121055.08UniSTS
AI072236  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812112,978,241 - 112,978,433UniSTSGRCm38
MGSCv3712114,216,452 - 114,216,644UniSTSGRCm37
Celera12114,188,272 - 114,188,464UniSTS
Cytogenetic Map12F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_028193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006516267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011244185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001780489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_381545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_872720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC073562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ573483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU148121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF737042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000011302   ⟹   ENSMUSP00000011302
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,923,705 - 112,964,324 (-)Ensembl
GRCm38.p6 Ensembl12112,960,085 - 113,000,704 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,946,265 - 112,951,680 (-)Ensembl
GRCm38.p6 Ensembl12112,982,645 - 112,988,060 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221415
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,943,445 - 112,946,724 (-)Ensembl
GRCm38.p6 Ensembl12112,979,825 - 112,983,104 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221537
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,925,343 - 112,926,134 (-)Ensembl
GRCm38.p6 Ensembl12112,961,723 - 112,962,514 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,933,757 - 112,950,139 (-)Ensembl
GRCm38.p6 Ensembl12112,970,137 - 112,986,519 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,924,595 - 112,925,049 (-)Ensembl
GRCm38.p6 Ensembl12112,960,975 - 112,961,429 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222247
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,951,331 - 112,964,016 (-)Ensembl
GRCm38.p6 Ensembl12112,987,711 - 113,000,396 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223037
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,956,425 - 112,964,052 (-)Ensembl
GRCm38.p6 Ensembl12112,992,805 - 113,000,432 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,932,894 - 112,950,353 (-)Ensembl
GRCm38.p6 Ensembl12112,969,274 - 112,986,733 (-)Ensembl
RefSeq Acc Id: NM_028193   ⟹   NP_082469
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,923,482 - 112,964,241 (-)NCBI
GRCm3812112,959,862 - 113,000,621 (-)NCBI
MGSCv3712114,198,073 - 114,238,832 (-)RGD
Celera12114,169,891 - 114,214,927 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516260   ⟹   XP_006516323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,327 (-)NCBI
GRCm3812112,955,631 - 113,000,704 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006516261   ⟹   XP_006516324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,327 (-)NCBI
GRCm3812112,960,043 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006516267   ⟹   XP_006516330
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,255 - 112,937,580 (-)NCBI
GRCm3812112,960,043 - 112,973,960 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244182   ⟹   XP_011242484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,325 (-)NCBI
GRCm3812112,960,043 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011244185   ⟹   XP_011242487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,946,678 (-)NCBI
GRCm3812112,960,043 - 112,982,973 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246942   ⟹   XP_030102802
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,325 (-)NCBI
GRCm3812112,960,043 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246944   ⟹   XP_030102804
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,325 (-)NCBI
GRCm3812112,960,043 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030246945   ⟹   XP_030102805
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,326 (-)NCBI
GRCm3812112,960,043 - 113,000,706 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001780489
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,927,130 - 112,964,327 (-)NCBI
GRCm3812112,963,510 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XR_381545
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,923,705 - 112,964,327 (-)NCBI
GRCm3812112,960,085 - 113,000,705 (-)NCBI
Sequence:
RefSeq Acc Id: XR_872720
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,919,251 - 112,964,327 (-)NCBI
GRCm3812112,955,631 - 113,000,704 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082469   ⟸   NM_028193
- UniProtKB: Q8CFK2 (UniProtKB/Swiss-Prot),   G3X8S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516324   ⟸   XM_006516261
- Peptide Label: isoform X2
- UniProtKB: Q8CFK2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516323   ⟸   XM_006516260
- Peptide Label: isoform X1
- UniProtKB: Q8CFK2 (UniProtKB/Swiss-Prot),   G3X8S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516330   ⟸   XM_006516267
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011242484   ⟸   XM_011244182
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011242487   ⟸   XM_011244185
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030102805   ⟸   XM_030246945
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030102804   ⟸   XM_030246944
- Peptide Label: isoform X5
RefSeq Acc Id: XP_030102802   ⟸   XM_030246942
- Peptide Label: isoform X4
RefSeq Acc Id: ENSMUSP00000011302   ⟸   ENSMUST00000011302
Protein Domains
Brf1 TBP-binding   TFIIB-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFK2-F1-model_v2 AlphaFold Q8CFK2 1-676 view protein structure

Promoters
RGD ID:8679414
Promoter ID:EPDNEW_M17738
Type:initiation region
Name:Brf1_1
Description:Mus musculus BRF1, RNA polymerase III transcription initiationfactor 90 kDa subunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812113,000,690 - 113,000,750EPDNEW
RGD ID:6822776
Promoter ID:MM_KWN:12895
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000011302,   NM_028193
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612114,238,386 - 114,238,886 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919558 AgrOrtholog
Ensembl Genes ENSMUSG00000011158 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000011302 ENTREZGENE
  ENSMUST00000011302.9 UniProtKB/TrEMBL
Gene3D-CATH 2.20.25.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BRF1_TBP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIB_cyclin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_TFIIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72308 UniProtKB/TrEMBL
MGD MGI:1919558 ENTREZGENE
NCBI Gene 72308 ENTREZGENE
PANTHER PTHR11618 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11618:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Zn_Ribbon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Brf1 PhenoGen
PRINTS TIFACTORIIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ZF_TFIIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc beta-ribbon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3X8S2 ENTREZGENE, UniProtKB/TrEMBL
  Q6PED6_MOUSE UniProtKB/TrEMBL
  Q8CFK2 ENTREZGENE
  Q9CS04_MOUSE UniProtKB/TrEMBL
  TF3B_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Brf1  BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit    BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED