Ell (elongation factor RNA polymerase II) - Rat Genome Database
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Gene: Ell (elongation factor RNA polymerase II) Mus musculus
Analyze
Symbol: Ell
Name: elongation factor RNA polymerase II
RGD ID: 1322411
MGI Page MGI
Description: Predicted to have phosphatase binding activity. Involved in in utero embryonic development and snRNA transcription by RNA polymerase II. Predicted to localize to nucleoplasm and transcriptionally active chromatin. Is expressed in several structures, including abdomen; central nervous system; genitourinary system; intestine; and liver. Orthologous to human ELL (elongation factor for RNA polymerase II); PARTICIPATES IN aldosterone signaling pathway; RNA polymerase II transcription elongation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: El; eleven-nineteen lysine-rich leukemia protein; Ell1; Me; Men; RNA polymerase II elongation factor ELL; RNA POLYMERASE II ELONGATION FACTOR ELL (ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN)
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,992,325 - 71,045,508 (+)NCBIGRCm39mm39
GRCm38870,539,675 - 70,592,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,539,457 - 70,592,858 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,063,574 - 73,116,757 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,468,691 - 73,521,813 (+)NCBImm8
Celera873,096,100 - 73,148,973 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:9037066   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11118326   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18590716   PMID:18799693   PMID:20059953   PMID:20064376   PMID:20211142   PMID:21267068   PMID:22195968   PMID:24127601  
PMID:32968282  


Genomics

Comparative Map Data
Ell
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,992,325 - 71,045,508 (+)NCBIGRCm39mm39
GRCm38870,539,675 - 70,592,858 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,539,457 - 70,592,858 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,063,574 - 73,116,757 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,468,691 - 73,521,813 (+)NCBImm8
Celera873,096,100 - 73,148,973 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
ELL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,442,663 - 18,522,116 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,442,663 - 18,522,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,553,473 - 18,632,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,414,473 - 18,493,918 (-)NCBINCBI36hg18NCBI36
Build 341918,414,474 - 18,493,918NCBI
Celera1918,455,673 - 18,535,143 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,116,226 - 18,195,558 (-)NCBIHuRef
CHM1_11918,553,828 - 18,633,421 (-)NCBICHM1_1
Ell
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,594,129 - 20,641,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,594,072 - 20,641,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,449,838 - 20,497,154 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,349,939 - 19,397,253 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,349,934 - 19,397,247 (-)NCBI
Celera1619,036,492 - 19,082,531 (-)NCBICelera
Cytogenetic Map16p14NCBI
Ell
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,054,292 - 3,092,973 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,054,296 - 3,094,125 (+)NCBIChiLan1.0ChiLan1.0
ELL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,894,054 - 18,969,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,894,054 - 18,969,923 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,923,035 - 17,999,842 (-)NCBIMhudiblu_PPA_v0panPan3
ELL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,489,219 - 44,598,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,512,665 - 44,592,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ell
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,745,862 - 2,812,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,277,171 - 59,360,246 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,277,164 - 59,359,986 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,997,333 - 59,025,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ELL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,915,878 - 17,000,275 (-)NCBI
ChlSab1.1 Ensembl616,917,953 - 17,000,230 (-)Ensembl
Ell
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,665,407 - 1,709,509 (-)NCBI

Position Markers
AW557197  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,592,361 - 70,592,490UniSTSGRCm38
MGSCv37873,116,260 - 73,116,389UniSTSGRCm37
Celera873,148,475 - 73,148,604UniSTS
Cytogenetic Map8C1UniSTS
Whitehead/MRC_RH8744.28UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:559
Count of miRNA genes:368
Interacting mature miRNAs:421
Transcripts:ENSMUST00000093454
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000093454   ⟹   ENSMUSP00000091163
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,539,688 - 70,592,858 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210155   ⟹   ENSMUSP00000147325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,539,457 - 70,581,641 (+)Ensembl
RefSeq Acc Id: NM_007924   ⟹   NP_031950
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,992,325 - 71,045,508 (+)NCBI
GRCm38870,539,675 - 70,592,858 (+)ENTREZGENE
MGSCv37873,063,574 - 73,116,757 (+)RGD
Celera873,096,100 - 73,148,973 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031950   ⟸   NM_007924
- UniProtKB: O08856 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000091163   ⟸   ENSMUST00000093454
RefSeq Acc Id: ENSMUSP00000147325   ⟸   ENSMUST00000210155
Protein Domains
ELL

Promoters
RGD ID:8667323
Promoter ID:EPDNEW_M11692
Type:multiple initiation site
Name:Ell_1
Description:Mus musculus elongation factor RNA polymerase II , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,539,695 - 70,539,755EPDNEW
RGD ID:6843065
Promoter ID:MM_KWN:54720
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_007924
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,062,581 - 73,063,782 (+)MPROMDB
RGD ID:6848283
Promoter ID:MM_ACW:47840
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Liver
Transcripts:ELL.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,107,719 - 73,108,219 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109377 AgrOrtholog
Ensembl Genes ENSMUSG00000070002 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000091163 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000147325 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093454 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000210155 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2670 UniProtKB/Swiss-Prot
InterPro E3_ELL-like UniProtKB/Swiss-Prot
  ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELL/occludin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELL_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:13716 UniProtKB/Swiss-Prot
MGD MGI:109377 ENTREZGENE
NCBI Gene 13716 ENTREZGENE
PANTHER PTHR23288 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23288:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ELL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Occludin_ELL UniProtKB/Swiss-Prot
PhenoGen Ell PhenoGen
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniGene Mm.271973 ENTREZGENE
UniProt A0A1B0GR04_MOUSE UniProtKB/TrEMBL
  ELL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TXY9 UniProtKB/Swiss-Prot