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Gene: PDE6B (phosphodiesterase 6B) Homo sapiens
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Symbol: PDE6B
Name: phosphodiesterase 6B
Description: Predicted to have 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in several processes, including detection of light stimulus; entrainment of circadian clock by photoperiod; and retina development in camera-type eye. Predicted to localize to photoreceptor outer segment. Implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSNB3; CSNBAD2; GMP-PDE beta; GMP-PDEbeta; PDEB; phosphodiesterase 6B, cGMP-specific, rod, beta; rd1; rod cGMP-phosphodiesterase beta-subunit; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; RP40
Orthologs:
Mus musculus (house mouse) : Pde6b (phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pde6b (phosphodiesterase 6B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde6b (phosphodiesterase 6B)
Canis lupus familiaris (dog) : PDE6B (phosphodiesterase 6B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde6b (phosphodiesterase 6B)
Sus scrofa (pig) : PDE6B (phosphodiesterase 6B)
Chlorocebus sabaeus (African green monkey) : PDE6B (phosphodiesterase 6B)
Heterocephalus glaber (naked mole-rat) : Pde6b (phosphodiesterase 6B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4625,584 - 670,782 (+)EnsemblGRCh38hg38GRCh38
GRCh384587,325 - 670,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374619,363 - 664,681 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364609,373 - 654,571 (+)NCBINCBI36hg18NCBI36
Build 344609,394 - 654,542NCBI
Celera4559,794 - 605,337 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef4594,501 - 639,532 (+)NCBIHuRef
CHM1_14619,152 - 664,469 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PDE6B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322283
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.