Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PUM2 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PUM2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PUM2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PUM2 mRNA | CTD | PMID:25975270 | 2,4-dinitrotoluene | affects expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of PUM2 mRNA | CTD | PMID:21346803 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of PUM2 mRNA | CTD | PMID:18648102 | acetylsalicylic acid | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Aspirin results in increased expression of PUM2 mRNA | CTD | PMID:15928584 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of PUM2 mRNA | CTD | PMID:19770486 | aristolochic acid A | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PUM2 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PUM2 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Benzo(a)pyrene results in increased expression of PUM2 mRNA | CTD | PMID:21839799 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[a]pyrene diol epoxide I | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | increases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of PUM2 mRNA | CTD | PMID:25181051 | bisphenol A | affects splicing | EXP | | 6480464 | bisphenol A affects the splicing of PUM2 mRNA | CTD | PMID:37894381 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PUM2 mRNA | CTD | PMID:33221593 | bisphenol F | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA | CTD | PMID:28628672 | cadmium atom | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PUM2 mRNA | CTD | PMID:35301059 | cadmium dichloride | decreases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of PUM2 mRNA | CTD | PMID:21297351 | cadmium dichloride | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PUM2 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PUM2 protein | CTD | PMID:35688186 | calciol | increases expression | EXP | | 6480464 | Cholecalciferol results in increased expression of PUM2 mRNA | CTD | PMID:16508948 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | copper(II) sulfate | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PUM2 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of PUM2 protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PUM2 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA | CTD | PMID:28628672 | dibenzo[a,l]pyrene | increases expression | EXP | | 6480464 | dibenzo(a and l)pyrene results in increased expression of PUM2 mRNA | CTD | PMID:25908611 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of PUM2 mRNA | CTD | PMID:17888722 | doxorubicin | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | PUM2 protein inhibits the reaction [Doxorubicin results in increased expression of MFF protein] | CTD | PMID:37406984 | doxorubicin | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PUM2 mRNA | CTD | PMID:29803840 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol affects the expression of and affects the splicing of PUM2 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PUM2 mRNA | CTD | PMID:22206623 | formaldehyde | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PUM2 mRNA | CTD | PMID:20655997 | FR900359 | affects phosphorylation | ISO | PUM2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PUM2 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PUM2 mRNA | CTD | PMID:22061828 | indometacin | multiple interactions | ISO | PUM2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PUM2 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PUM2 protein | CTD | PMID:32959892 | oxaliplatin | multiple interactions | ISO | Pum2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PUM2 mRNA | CTD | PMID:21420995 | paracetamol | decreases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of PUM2 mRNA | CTD | PMID:33387578 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of PUM2 mRNA | CTD | PMID:21278054 | sunitinib | increases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PUM2 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of PUM2 mRNA | CTD | PMID:20937368 | tert-butyl hydroperoxide | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of PUM2 mRNA | CTD | PMID:15336504 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of PUM2 mRNA | CTD | PMID:29264374 | topotecan | multiple interactions | ISO | Pum2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | topotecan | decreases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of PUM2 mRNA | CTD | PMID:25729387 | trichostatin A | affects expression | ISO | PUM2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PUM2 mRNA | CTD | PMID:28542535 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of PUM2 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of PUM2 mRNA | CTD | PMID:28973697 | valproic acid | decreases expression | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PUM2 mRNA | CTD | PMID:23179753 | valproic acid | decreases methylation | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PUM2 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | PUM2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PUM2 mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | ISO | Pum2 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of PUM2 mRNA | CTD | PMID:20566332 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
Cellular Component
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Molecular Function
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. | Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48. |
| 4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 5. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11780640 | PMID:12226475 | PMID:12459267 | PMID:12477932 | PMID:12511597 | PMID:12520002 | PMID:12667987 |
| PMID:12904583 | PMID:14610273 | PMID:15489334 | PMID:15617101 | PMID:15741177 | PMID:16033648 | PMID:16041388 | PMID:16141072 | PMID:16141073 | PMID:16775137 | PMID:17219433 | PMID:17768378 |
| PMID:17967808 | PMID:18089289 | PMID:18799693 | PMID:19540345 | PMID:19861488 | PMID:20159962 | PMID:21267068 | PMID:21460039 | PMID:21677750 | PMID:21865157 | PMID:21873635 | PMID:22016787 |
| PMID:22496444 | PMID:22645261 | PMID:22802532 | PMID:22902294 | PMID:23892456 | PMID:24194600 | PMID:25100735 | PMID:26391954 | PMID:26589352 | PMID:27170441 | PMID:28378742 | PMID:28794184 |
| PMID:29046322 | PMID:29358566 | PMID:30181804 | PMID:30256721 | PMID:30642763 | PMID:30735131 | PMID:30811992 | PMID:31077711 | PMID:31138677 | PMID:31606248 | PMID:31993882 | PMID:32198202 |
| PMID:34133714 | PMID:34161769 | PMID:34321999 | PMID:34445704 | PMID:34678304 | PMID:35262486 | PMID:35338151 | PMID:35507203 | PMID:35678316 | PMID:35997855 | PMID:37062520 | PMID:37088847 |
| PMID:37913857 |
Genomics
Comparative Map Data
| Pum2 (Mus musculus - house mouse) |
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| PUM2 (Homo sapiens - human) |
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| Pum2 (Rattus norvegicus - Norway rat) |
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| Pum2 (Chinchilla lanigera - long-tailed chinchilla) |
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| PUM2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PUM2 (Canis lupus familiaris - dog) |
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| Pum2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PUM2 (Sus scrofa - pig) |
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| PUM2 (Chlorocebus sabaeus - green monkey) |
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| Pum2 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Pum2
1738 total Variants 
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