Loxl3 (lysyl oxidase-like 3) - Rat Genome Database
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Gene: Loxl3 (lysyl oxidase-like 3) Mus musculus
Analyze
Symbol: Loxl3
Name: lysyl oxidase-like 3
RGD ID: 1322240
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; connective tissue; limb mesenchyme; sensory organ; and skeleton. Orthologous to human LOXL3 (lysyl oxidase like 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L; Lor2; Loxl2; lysyl oxidase homolog 3; lysyl oxidase-like 2; lysyl oxidase-like protein 3; lysyl oxidase-related protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,011,186 - 83,029,547 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,011,154 - 83,029,543 (+)Ensembl
GRCm38683,034,205 - 83,052,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,984,218 - 83,002,558 (+)NCBIGRCm37mm9NCBIm37
MGSCv36682,999,882 - 83,018,222 (+)NCBImm8
Celera685,015,734 - 85,035,153 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:9927484   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17626619   PMID:18554416  
PMID:19458888   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24006456   PMID:26307084   PMID:26954549   PMID:27645581   PMID:28065600   PMID:32325033  


Genomics

Comparative Map Data
Loxl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,011,186 - 83,029,547 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,011,154 - 83,029,543 (+)Ensembl
GRCm38683,034,205 - 83,052,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,984,218 - 83,002,558 (+)NCBIGRCm37mm9NCBIm37
MGSCv36682,999,882 - 83,018,222 (+)NCBImm8
Celera685,015,734 - 85,035,153 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
LOXL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl274,532,258 - 74,555,690 (-)EnsemblGRCh38hg38GRCh38
GRCh38274,532,258 - 74,555,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37274,759,385 - 74,781,069 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,613,454 - 74,634,570 (-)NCBINCBI36hg18NCBI36
Build 34274,671,600 - 74,692,717NCBI
Celera274,591,054 - 74,612,170 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef274,496,207 - 74,517,323 (-)NCBIHuRef
CHM1_1274,688,781 - 74,710,486 (-)NCBICHM1_1
Loxl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,540,640 - 115,556,958 (+)NCBI
Rnor_6.0 Ensembl4113,866,804 - 113,883,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04113,866,782 - 113,883,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,552,500 - 178,568,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,245,933 - 117,262,248 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,491,707 - 117,506,378 (+)NCBI
Celera4104,535,320 - 104,551,634 (+)NCBICelera
Cytogenetic Map4q34NCBI
Loxl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,236,836 - 11,259,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,236,415 - 11,255,801 (+)NCBIChiLan1.0ChiLan1.0
LOXL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,105,957 - 76,128,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,105,957 - 76,128,495 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,598,870 - 74,622,502 (-)NCBIMhudiblu_PPA_v0panPan3
LOXL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1748,591,768 - 48,610,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11748,590,996 - 48,610,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Loxl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936556745,798 - 765,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOXL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,498,189 - 68,520,115 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,498,114 - 68,516,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,670,347 - 71,688,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOXL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,722,588 - 32,745,480 (+)NCBI
ChlSab1.1 Ensembl1432,725,112 - 32,745,004 (+)Ensembl
Loxl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474928,959,682 - 28,980,428 (+)NCBI

Position Markers
AI481710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,051,361 - 83,051,485UniSTSGRCm38
MGSCv37683,001,355 - 83,001,479UniSTSGRCm37
Celera685,033,948 - 85,034,072UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.76UniSTS
cM Map634.75UniSTS
Whitehead/MRC_RH6850.27UniSTS
Loxl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,049,922 - 83,051,297UniSTSGRCm38
MGSCv37682,999,916 - 83,001,291UniSTSGRCm37
Celera685,032,509 - 85,033,884UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.755UniSTS
D6UmiJ17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37682,991,381 - 82,991,527UniSTSGRCm37
Celera685,023,896 - 85,024,040UniSTS
Celera685,022,898 - 85,023,044UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.71UniSTS
D6UmiJ26  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,048,166 - 83,048,349UniSTSGRCm38
MGSCv37682,998,160 - 82,998,343UniSTSGRCm37
Celera685,030,743 - 85,030,936UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.72UniSTS
RH124140  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37683,000,163 - 83,000,396UniSTSGRCm37
MGSCv371470,088,888 - 70,090,035UniSTSGRCm37
Celera685,032,756 - 85,032,989UniSTS
Celera1467,224,707 - 67,225,854UniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map14D2UniSTS
cM Map14 UniSTS
MARC_4349-4350:991938479:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,048,003 - 83,048,685UniSTSGRCm38
MGSCv37682,997,997 - 82,998,679UniSTSGRCm37
Celera685,030,580 - 85,031,272UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.76UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2207
Count of miRNA genes:652
Interacting mature miRNAs:793
Transcripts:ENSMUST00000000707, ENSMUST00000101257, ENSMUST00000152679, ENSMUST00000155502
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000707   ⟹   ENSMUSP00000000707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101257   ⟹   ENSMUSP00000098815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152679
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,037,555 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,049,868 - 83,050,667 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,038,400 - 83,045,096 (+)Ensembl
RefSeq Acc Id: NM_013586   ⟹   NP_038614
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,011,186 - 83,029,547 (+)NCBI
GRCm38683,034,205 - 83,052,566 (+)NCBI
MGSCv37682,984,218 - 83,002,558 (+)RGD
Celera685,015,734 - 85,035,153 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038614   ⟸   NM_013586
- Peptide Label: precursor
- UniProtKB: Q9Z175 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000707   ⟸   ENSMUST00000000707
RefSeq Acc Id: ENSMUSP00000098815   ⟸   ENSMUST00000101257
Protein Domains
SRCR

Promoters
RGD ID:6839571
Promoter ID:MM_KWN:46560
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000053823,   OTTMUST00000053824,   OTTMUST00000053825
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36682,983,216 - 82,983,716 (+)MPROMDB
RGD ID:6839573
Promoter ID:MM_KWN:46561
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000053826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36682,998,931 - 83,000,257 (+)MPROMDB
RGD ID:6890110
Promoter ID:EPDNEW_M8505
Type:initiation region
Name:Loxl3_1
Description:Mus musculus lysyl oxidase-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,034,220 - 83,034,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1337004 AgrOrtholog
Ensembl Genes ENSMUSG00000000693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000000707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000098815 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000101257 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/Swiss-Prot
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16950 UniProtKB/Swiss-Prot
MGD MGI:1337004 ENTREZGENE
NCBI Gene 16950 ENTREZGENE
Pfam Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Loxl3 PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/Swiss-Prot
  SRCR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q0X7_MOUSE UniProtKB/TrEMBL
  LOXL3_MOUSE UniProtKB/Swiss-Prot
  Q3UM16_MOUSE UniProtKB/TrEMBL
  Q9Z175 ENTREZGENE
UniProt Secondary Q91VN8 UniProtKB/Swiss-Prot
  Q9JJ39 UniProtKB/Swiss-Prot