Loxl3 (lysyl oxidase-like 3) - Rat Genome Database
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Gene: Loxl3 (lysyl oxidase-like 3) Mus musculus
Analyze
Symbol: Loxl3
Name: lysyl oxidase-like 3
RGD ID: 1322240
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; connective tissue; limb mesenchyme; sensory organ; and skeleton. Orthologous to human LOXL3 (lysyl oxidase like 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L; Lor2; Loxl2; lysyl oxidase homolog 3; lysyl oxidase-like 2; lysyl oxidase-like protein 3; lysyl oxidase-related protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,011,186 - 83,029,547 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,011,154 - 83,029,543 (+)Ensembl
GRCm38683,034,205 - 83,052,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,984,218 - 83,002,558 (+)NCBIGRCm37mm9NCBIm37
MGSCv36682,999,882 - 83,018,222 (+)NCBImm8
Celera685,015,734 - 85,035,153 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:9927484   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17626619   PMID:18554416  
PMID:19458888   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24006456   PMID:26307084   PMID:26954549   PMID:27645581   PMID:28065600   PMID:32325033  


Genomics

Comparative Map Data
Loxl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,011,186 - 83,029,547 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,011,154 - 83,029,543 (+)Ensembl
GRCm38683,034,205 - 83,052,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,984,218 - 83,002,558 (+)NCBIGRCm37mm9NCBIm37
MGSCv36682,999,882 - 83,018,222 (+)NCBImm8
Celera685,015,734 - 85,035,153 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
LOXL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl274,532,258 - 74,555,690 (-)EnsemblGRCh38hg38GRCh38
GRCh38274,532,258 - 74,555,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37274,759,385 - 74,781,069 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,613,454 - 74,634,570 (-)NCBINCBI36hg18NCBI36
Build 34274,671,600 - 74,692,717NCBI
Celera274,591,054 - 74,612,170 (-)NCBI
Cytogenetic Map2p13.1NCBI
HuRef274,496,207 - 74,517,323 (-)NCBIHuRef
CHM1_1274,688,781 - 74,710,486 (-)NCBICHM1_1
Loxl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,540,640 - 115,556,958 (+)NCBI
Rnor_6.0 Ensembl4113,866,804 - 113,883,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04113,866,782 - 113,883,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04178,552,500 - 178,568,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,245,933 - 117,262,248 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,491,707 - 117,506,378 (+)NCBI
Celera4104,535,320 - 104,551,634 (+)NCBICelera
Cytogenetic Map4q34NCBI
Loxl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,236,836 - 11,259,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,236,415 - 11,255,801 (+)NCBIChiLan1.0ChiLan1.0
LOXL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A76,105,957 - 76,128,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,105,957 - 76,128,495 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A74,598,870 - 74,622,502 (-)NCBIMhudiblu_PPA_v0panPan3
LOXL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1748,591,768 - 48,610,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11748,590,996 - 48,610,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Loxl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936556745,798 - 765,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOXL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,498,189 - 68,520,115 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,498,114 - 68,516,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,670,347 - 71,688,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOXL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,722,588 - 32,745,480 (+)NCBI
ChlSab1.1 Ensembl1432,725,112 - 32,745,004 (+)Ensembl
Loxl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474928,959,682 - 28,980,428 (+)NCBI

Position Markers
AI481710  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,051,361 - 83,051,485UniSTSGRCm38
MGSCv37683,001,355 - 83,001,479UniSTSGRCm37
Celera685,033,948 - 85,034,072UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.76UniSTS
cM Map634.75UniSTS
Whitehead/MRC_RH6850.27UniSTS
Loxl3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,049,922 - 83,051,297UniSTSGRCm38
MGSCv37682,999,916 - 83,001,291UniSTSGRCm37
Celera685,032,509 - 85,033,884UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.755UniSTS
D6UmiJ17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37682,991,381 - 82,991,527UniSTSGRCm37
Celera685,023,896 - 85,024,040UniSTS
Celera685,022,898 - 85,023,044UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.71UniSTS
D6UmiJ26  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,048,166 - 83,048,349UniSTSGRCm38
MGSCv37682,998,160 - 82,998,343UniSTSGRCm37
Celera685,030,743 - 85,030,936UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.72UniSTS
RH124140  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37683,000,163 - 83,000,396UniSTSGRCm37
MGSCv371470,088,888 - 70,090,035UniSTSGRCm37
Celera685,032,756 - 85,032,989UniSTS
Celera1467,224,707 - 67,225,854UniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map14D2UniSTS
cM Map14 UniSTS
MARC_4349-4350:991938479:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,048,003 - 83,048,685UniSTSGRCm38
MGSCv37682,997,997 - 82,998,679UniSTSGRCm37
Celera685,030,580 - 85,031,272UniSTS
Cytogenetic Map6C3UniSTS
cM Map634.76UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2207
Count of miRNA genes:652
Interacting mature miRNAs:793
Transcripts:ENSMUST00000000707, ENSMUST00000101257, ENSMUST00000152679, ENSMUST00000155502
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000707   ⟹   ENSMUSP00000000707
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101257   ⟹   ENSMUSP00000098815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152679
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,034,173 - 83,037,555 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,049,868 - 83,050,667 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,038,400 - 83,045,096 (+)Ensembl
RefSeq Acc Id: NM_013586   ⟹   NP_038614
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,011,186 - 83,029,547 (+)NCBI
GRCm38683,034,205 - 83,052,566 (+)NCBI
MGSCv37682,984,218 - 83,002,558 (+)RGD
Celera685,015,734 - 85,035,153 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038614   ⟸   NM_013586
- Peptide Label: precursor
- UniProtKB: Q9Z175 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000707   ⟸   ENSMUST00000000707
RefSeq Acc Id: ENSMUSP00000098815   ⟸   ENSMUST00000101257
Protein Domains
SRCR

Promoters
RGD ID:6839571
Promoter ID:MM_KWN:46560
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000053823,   OTTMUST00000053824,   OTTMUST00000053825
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36682,983,216 - 82,983,716 (+)MPROMDB
RGD ID:6839573
Promoter ID:MM_KWN:46561
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000053826
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36682,998,931 - 83,000,257 (+)MPROMDB
RGD ID:6890110
Promoter ID:EPDNEW_M8505
Type:initiation region
Name:Loxl3_1
Description:Mus musculus lysyl oxidase-like 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,034,220 - 83,034,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1337004 AgrOrtholog
Ensembl Genes ENSMUSG00000000693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000000707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000098815 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000101257 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/Swiss-Prot
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16950 UniProtKB/Swiss-Prot
MGD MGI:1337004 ENTREZGENE
NCBI Gene 16950 ENTREZGENE
Pfam Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Loxl3 PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/Swiss-Prot
  SRCR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q0X7_MOUSE UniProtKB/TrEMBL
  LOXL3_MOUSE UniProtKB/Swiss-Prot
  Q3UM16_MOUSE UniProtKB/TrEMBL
  Q9Z175 ENTREZGENE
UniProt Secondary Q91VN8 UniProtKB/Swiss-Prot
  Q9JJ39 UniProtKB/Swiss-Prot