Naa50 (N(alpha)-acetyltransferase 50, NatE catalytic subunit) - Rat Genome Database

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Gene: Naa50 (N(alpha)-acetyltransferase 50, NatE catalytic subunit) Mus musculus
Analyze
Symbol: Naa50
Name: N(alpha)-acetyltransferase 50, NatE catalytic subunit
RGD ID: 1322132
MGI Page MGI
Description: Predicted to enable H4 histone acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and peptidyl-lysine acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion and protein acetylation. Predicted to be located in cytosol and nucleus. Predicted to be part of NatA complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; integumental system; nose; respiratory system; and telencephalon. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2600005K24Rik; 2810441M03Rik; AW112078; Mak; Mak3; Mak3 homolog; Mak3p; Mak3p homolog; N-acetyltransferase 13; N-acetyltransferase NAT13; N-alpha-acetyltransferase 50; N-alpha-acetyltransferase 50, NatE catalytic subunit; N-epsilon-acetyltransferase 50; Na; Nalpha acetyltransferase 50; Nat; Nat13; Nat5; natE catalytic subunit; San
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,960,154 - 43,983,825 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,960,193 - 43,983,729 (+)Ensembl
GRCm381644,139,791 - 44,163,462 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1644,139,830 - 44,163,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv371644,139,922 - 44,163,477 (+)NCBIGRCm37mm9NCBIm37
MGSCv361644,059,141 - 44,082,696 (+)NCBImm8
Celera1644,497,008 - 44,520,827 (+)NCBICelera
Cytogenetic Map16B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (ISO)
NatA complex  (IBA,ISO)
nucleus  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11274203   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479  
PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16484612   PMID:16507339   PMID:18799693   PMID:19521500   PMID:20360068   PMID:21873635   PMID:26496610   PMID:32325033  


Genomics

Comparative Map Data
Naa50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391643,960,154 - 43,983,825 (+)NCBIGRCm39mm39
GRCm39 Ensembl1643,960,193 - 43,983,729 (+)Ensembl
GRCm381644,139,791 - 44,163,462 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1644,139,830 - 44,163,366 (+)EnsemblGRCm38mm10GRCm38
MGSCv371644,139,922 - 44,163,477 (+)NCBIGRCm37mm9NCBIm37
MGSCv361644,059,141 - 44,082,696 (+)NCBImm8
Celera1644,497,008 - 44,520,827 (+)NCBICelera
Cytogenetic Map16B4NCBI
NAA50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3113,716,458 - 113,746,300 (-)EnsemblGRCh38hg38GRCh38
GRCh383113,716,458 - 113,746,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373113,435,305 - 113,465,096 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363114,920,531 - 114,947,786 (-)NCBINCBI36hg18NCBI36
Build 343114,920,530 - 114,947,786NCBI
Celera3111,846,332 - 111,873,586 (-)NCBI
Cytogenetic Map3q13.31NCBI
HuRef3110,810,207 - 110,840,018 (-)NCBIHuRef
CHM1_13113,398,653 - 113,428,466 (-)NCBICHM1_1
Naa50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,538,366 - 56,560,842 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1156,538,366 - 56,560,842 (-)Ensembl
Rnor_6.01161,508,162 - 61,530,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,462,994 - 61,530,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1161,466,962 - 61,470,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01165,614,950 - 65,637,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,103,982 - 58,126,566 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,165,242 - 58,184,158 (-)NCBI
Celera1156,091,522 - 56,113,995 (-)NCBICelera
Cytogenetic Map11q21NCBI
Naa50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542713,845,806 - 13,868,323 (-)NCBIChiLan1.0ChiLan1.0
NAA50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13117,781,455 - 117,808,913 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3117,781,455 - 117,808,913 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03110,860,595 - 110,888,033 (-)NCBIMhudiblu_PPA_v0panPan3
NAA50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3318,111,480 - 18,139,497 (-)NCBI
ROS_Cfam_1.03318,253,597 - 18,281,699 (-)NCBI
UMICH_Zoey_3.13318,057,364 - 18,085,408 (-)NCBI
UNSW_CanFamBas_1.03318,104,745 - 18,132,483 (-)NCBI
UU_Cfam_GSD_1.03318,655,841 - 18,683,924 (-)NCBI
Naa50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602136,264,699 - 136,285,768 (+)NCBI
SpeTri2.0NW_0049365361,221,080 - 1,257,196 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAA50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13146,193,218 - 146,222,133 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113146,193,186 - 146,217,739 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213155,778,467 - 155,802,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAA50
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12267,113,126 - 67,142,391 (+)NCBI
ChlSab1.1 Ensembl2267,113,123 - 67,139,627 (+)Ensembl
Vero_WHO_p1.0NW_02366604199,328,044 - 99,356,888 (-)NCBI
Naa50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473134,781,120 - 34,808,863 (+)NCBI

Position Markers
AW112078  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381644,163,002 - 44,163,141UniSTSGRCm38
MGSCv371644,163,115 - 44,163,254UniSTSGRCm37
Celera1644,520,465 - 44,520,604UniSTS
Cytogenetic Map16B4UniSTS
Whitehead/MRC_RH16544.13UniSTS
UniSTS:237514  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381644,163,079 - 44,163,329UniSTSGRCm38
MGSCv371644,163,192 - 44,163,442UniSTSGRCm37
Celera1644,520,542 - 44,520,792UniSTS
Cytogenetic Map16B4UniSTS
Naa50  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16B4UniSTS
cM Map1628.47UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162020057985803938Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162211802156118212Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2295650257773713Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162897245062972589Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162897245062972589Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162897245062972589Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162897245062972589Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163249243266492570Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3270409165669666Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163562627392776120Mouse
10412263Gvhd6_mgraft-versus host disease 6 (mouse)Not determined163624048745690785Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163750000084900000Mouse
35673309Ari5_mantibody response to influenza 5, day 15, IgG1 (mouse)164000000044700000Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164023351973127497Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164057877278218584Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164077356074773713Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164237745482534286Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2211
Count of miRNA genes:503
Interacting mature miRNAs:582
Transcripts:ENSMUST00000063520, ENSMUST00000063542, ENSMUST00000159514, ENSMUST00000161326
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001347239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_028108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036160132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI119854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI390712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF020411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU756675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY062588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY759070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000063520   ⟹   ENSMUSP00000070140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,960,249 - 43,982,835 (+)Ensembl
GRCm38.p6 Ensembl1644,139,886 - 44,162,472 (+)Ensembl
RefSeq Acc Id: ENSMUST00000063542   ⟹   ENSMUSP00000067361
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,960,255 - 43,981,537 (+)Ensembl
GRCm38.p6 Ensembl1644,139,892 - 44,161,174 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159514   ⟹   ENSMUSP00000125517
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,960,193 - 43,982,837 (+)Ensembl
GRCm38.p6 Ensembl1644,139,830 - 44,162,474 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161326   ⟹   ENSMUSP00000124291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1643,960,216 - 43,983,729 (+)Ensembl
GRCm38.p6 Ensembl1644,139,853 - 44,163,366 (+)Ensembl
RefSeq Acc Id: NM_001347239   ⟹   NP_001334168
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,960,154 - 43,983,825 (+)NCBI
GRCm381644,139,791 - 44,163,462 (+)NCBI
Sequence:
RefSeq Acc Id: NM_028108   ⟹   NP_082384
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,960,172 - 43,983,727 (+)NCBI
GRCm381644,139,809 - 44,163,364 (+)NCBI
MGSCv371644,139,922 - 44,163,477 (+)RGD
Celera1644,497,008 - 44,520,827 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036160132   ⟹   XP_036016025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391643,965,149 - 43,983,729 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_082384   ⟸   NM_028108
- Peptide Label: isoform 1
- UniProtKB: Q6PGB6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001334168   ⟸   NM_001347239
- Peptide Label: isoform 2
- UniProtKB: Q6PGB6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000125517   ⟸   ENSMUST00000159514
RefSeq Acc Id: ENSMUSP00000124291   ⟸   ENSMUST00000161326
RefSeq Acc Id: ENSMUSP00000070140   ⟸   ENSMUST00000063520
RefSeq Acc Id: ENSMUSP00000067361   ⟸   ENSMUST00000063542
RefSeq Acc Id: XP_036016025   ⟸   XM_036160132
- Peptide Label: isoform X1
Protein Domains
N-acetyltransferase

Promoters
RGD ID:6827310
Promoter ID:MM_KWN:21062
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000063542,   ENSMUST00000116602,   NM_028108,   OTTMUST00000057143,   OTTMUST00000057146,   OTTMUST00000057147,   OTTMUST00000057148,   UC007ZGV.1,   UC007ZGW.1,   UC007ZGZ.1,   UC007ZHA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361644,138,276 - 44,140,662 (+)MPROMDB
RGD ID:8686244
Promoter ID:EPDNEW_M21153
Type:initiation region
Name:Naa50_1
Description:Mus musculus N-acetyltransferase 50, NatE catalytic subunit ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381644,139,838 - 44,139,898EPDNEW
RGD ID:6827284
Promoter ID:MM_KWN:21063
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4
Transcripts:ENSMUST00000023382
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361644,145,166 - 44,145,666 (+)MPROMDB
RGD ID:6827286
Promoter ID:MM_KWN:21064
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2
Transcripts:ENSMUST00000114661
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361644,156,691 - 44,157,191 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919367 AgrOrtholog
Ensembl Genes ENSMUSG00000022698 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000067361 UniProtKB/Swiss-Prot
  ENSMUSP00000070140 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000124291 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000125517 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000063520 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000063542 UniProtKB/Swiss-Prot
  ENSMUST00000159514 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000161326 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
KEGG Report mmu:72117 UniProtKB/Swiss-Prot
MGD MGI:1919367 ENTREZGENE
NCBI Gene 72117 ENTREZGENE
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Naa50 PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
UniProt NAA50_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TH79 UniProtKB/Swiss-Prot
  Q3TK59 UniProtKB/Swiss-Prot
  Q7TML2 UniProtKB/Swiss-Prot
  Q80VE3 UniProtKB/Swiss-Prot
  Q9D0Q8 UniProtKB/Swiss-Prot