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Gene: SORL1 (sortilin related receptor 1) Homo sapiens
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Symbol: SORL1
Name: sortilin related receptor 1
Description: Exhibits several functions, including ADP-ribosylation factor binding activity; low-density lipoprotein particle binding activity; and peptide binding activity. Involved in several processes, including negative regulation of amyloid precursor protein catabolic process; positive regulation of intracellular transport; and protein localization to organelle. Localizes to several cellular components, including Golgi apparatus subcompartment; endosome; and nuclear envelope lumen. Implicated in Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C11orf32; chromosome 11 open reading frame 32; FLJ21930; FLJ39258; gp250; LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LRP9; mosaic protein LR11; SORLA; SorLA-1; sortilin-related receptor; sortilin-related receptor containing LDLR class A repeats; sortilin-related receptor, L(DLR class) A repeats containing; sortilin-related receptor, L(DLR class) A repeats-containing; sorting protein-related receptor containing LDLR class A repeats
Orthologs:
Mus musculus (house mouse) : Sorl1 (sortilin-related receptor, LDLR class A repeats-containing)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sorl1 (sortilin related receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sorl1 (sortilin related receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SORL1 (sortilin related receptor 1)
Canis lupus familiaris (dog) : SORL1 (sortilin related receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sorl1 (sortilin related receptor 1)
Sus scrofa (pig) : SORL1 (sortilin related receptor 1)
Chlorocebus sabaeus (African green monkey) : SORL1 (sortilin related receptor 1)
Heterocephalus glaber (naked mole-rat) : Sorl1 (sortilin related receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: In some of the published literature, this gene has been incorrectly associated with the LRP9 alias, but the LRP9 alias more correctly refers to Gene ID 26020, LRP10. [05 May 2010]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl11121,452,314 - 121,633,763 (+)EnsemblGRCh38hg38GRCh38
GRCh3811121,452,314 - 121,633,763 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711121,322,912 - 121,504,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611120,828,130 - 121,005,621 (+)NCBINCBI36hg18NCBI36
Build 3411120,828,129 - 121,005,610NCBI
Celera11118,482,367 - 118,662,804 (+)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11117,266,146 - 117,448,320 (+)NCBIHuRef
CHM1_111121,210,607 - 121,392,157 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SORL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322123
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.