Dppa3 (developmental pluripotency-associated 3) - Rat Genome Database

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Gene: Dppa3 (developmental pluripotency-associated 3) Mus musculus
Analyze
Symbol: Dppa3
Name: developmental pluripotency-associated 3
RGD ID: 1322116
MGI Page MGI
Description: Enables methylated histone binding activity. Involved in negative regulation of DNA demethylation; protection of DNA demethylation of female pronucleus; and regulation of genetic imprinting. Acts upstream of or within embryonic cleavage. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; hindgut diverticulum; and primordial germ cell. Orthologous to human DPPA3 (developmental pluripotency associated 3); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; all-trans-retinoic acid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 2410075G02Rik; compaction-associated protein 1; developmental pluripotency-associated protein 3; MGC117617; MGC130308; MGC130309; PCG7; PGC; PGC7; primordial germ cell 7; primordial germ cell protein 7; st; Stella
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Dppa3-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,603,383 - 122,607,230 (+)NCBIGRCm39mm39
GRCm39 Ensembl6122,603,369 - 122,607,231 (+)Ensembl
GRCm386122,626,424 - 122,630,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,626,410 - 122,630,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,576,442 - 122,580,289 (+)NCBIGRCm37mm9NCBIm37
MGSCv366122,592,043 - 122,595,890 (+)NCBImm8
Celera6124,426,164 - 124,430,002 (+)NCBICelera
Cytogenetic Map6F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,ISO)
female pronucleus  (IDA)
male pronucleus  (IDA)
nucleus  (IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. MGD data from the GO Consortium
2. MGD IEA
3. RGD automated import pipeline
4. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11900980   PMID:12124616   PMID:12466851   PMID:12477932   PMID:12620990   PMID:12659663   PMID:14511483  
PMID:14610273   PMID:14654002   PMID:14684992   PMID:15018652   PMID:15489334   PMID:15582778   PMID:15937476   PMID:15939376   PMID:16141072   PMID:16141073   PMID:16291796   PMID:16310179  
PMID:16602821   PMID:16887830   PMID:17055474   PMID:17143267   PMID:17287250   PMID:17369397   PMID:17567665   PMID:17567914   PMID:17676999   PMID:17913791   PMID:18500982   PMID:18505827  
PMID:18940731   PMID:18983963   PMID:19279135   PMID:19371732   PMID:19776388   PMID:20018908   PMID:20845430   PMID:21056461   PMID:21057502   PMID:21267068   PMID:21321204   PMID:21407207  
PMID:21441929   PMID:21504946   PMID:21525417   PMID:21731673   PMID:21786403   PMID:21873635   PMID:22019303   PMID:22034526   PMID:22216013   PMID:22327294   PMID:22722204   PMID:23022299  
PMID:23077213   PMID:23154982   PMID:23469192   PMID:23473982   PMID:23497137   PMID:23553930   PMID:23595900   PMID:23934214   PMID:24009519   PMID:24089201   PMID:24692758   PMID:24859004  
PMID:25010009   PMID:25263278   PMID:25613421   PMID:25694116   PMID:25810472   PMID:26095607   PMID:26325466   PMID:26388201   PMID:26515778   PMID:27002001   PMID:27586544   PMID:27696611  
PMID:28322735   PMID:28323615   PMID:28330620   PMID:28712289   PMID:28739047   PMID:28963472   PMID:29158485   PMID:29459681   PMID:29501710   PMID:30275529   PMID:30481289   PMID:30487604  
PMID:30842446   PMID:31018966   PMID:31037145   PMID:31421827   PMID:32161582   PMID:32332736   PMID:32892421   PMID:33008598   PMID:33634103   PMID:34174788  


Genomics

Comparative Map Data
Dppa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396122,603,383 - 122,607,230 (+)NCBIGRCm39mm39
GRCm39 Ensembl6122,603,369 - 122,607,231 (+)Ensembl
GRCm386122,626,424 - 122,630,271 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6122,626,410 - 122,630,272 (+)EnsemblGRCm38mm10GRCm38
MGSCv376122,576,442 - 122,580,289 (+)NCBIGRCm37mm9NCBIm37
MGSCv366122,592,043 - 122,595,890 (+)NCBImm8
Celera6124,426,164 - 124,430,002 (+)NCBICelera
Cytogenetic Map6F1NCBI
DPPA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,711,433 - 7,717,559 (+)EnsemblGRCh38hg38GRCh38
GRCh38127,711,433 - 7,717,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,864,029 - 7,870,155 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,755,356 - 7,761,422 (+)NCBINCBI36hg18NCBI36
Build 34127,755,355 - 7,761,417NCBI
Celera129,442,212 - 9,448,285 (+)NCBI
Cytogenetic Map12p13.31NCBI
HuRef127,678,041 - 7,684,114 (+)NCBIHuRef
CHM1_1127,862,915 - 7,869,510 (+)NCBICHM1_1
Dppa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24155,851,461 - 155,854,845 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4155,815,296 - 155,854,861 (+)Ensembl
Rnor_6.04155,437,675 - 155,441,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4155,437,675 - 155,440,828 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,298,713 - 111,299,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04222,459,195 - 222,464,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44159,083,360 - 159,086,744 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14159,328,295 - 159,331,696 (+)NCBI
Celera4144,670,614 - 144,673,998 (+)NCBICelera
Cytogenetic Map4q42NCBI
DPPA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,994,606 - 8,000,731 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0127,834,298 - 7,841,064 (+)NCBIMhudiblu_PPA_v0panPan3
DPPA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,114,192 - 37,196,434 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,417,788 - 9,502,171 (-)NCBI
ROS_Cfam_1.02737,463,510 - 37,549,060 (+)NCBI
UMICH_Zoey_3.12737,344,581 - 37,429,586 (+)NCBI
UNSW_CanFamBas_1.02737,379,470 - 37,464,429 (+)NCBI
UU_Cfam_GSD_1.0278,902,815 - 8,988,437 (-)NCBI
DPPA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1562,861,492 - 62,868,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,691,481 - 65,702,154 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DPPA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,743,045 - 7,751,285 (+)NCBI
Vero_WHO_p1.0NW_023666063450,101 - 455,796 (-)NCBI
Dppa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248604,974,941 - 4,978,295 (+)NCBI

Position Markers
Dppa3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X37,625,732 - 37,625,831UniSTSGRCm38
MGSCv37X35,040,239 - 35,040,338UniSTSGRCm37
CeleraX24,522,529 - 24,522,628UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic MapXA3.3UniSTS
cM Map148.0UniSTS
cM Map6 UniSTS
Dppa3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F2UniSTS
Cytogenetic MapXA3.3UniSTS
cM Map6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115242853146429238Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115569842149572401Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116664897128519025Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120439808149736546Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115601042149601187Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115569842149572401Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115717516132601187Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117082986149736546Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114368732145656013Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112269957125356785Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110838217144838360Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115569842149572401Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116852888149736546Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111165485145165578Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112269957147052561Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:90
Interacting mature miRNAs:94
Transcripts:ENSMUST00000049644, ENSMUST00000123429
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049644   ⟹   ENSMUSP00000062832
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6122,603,369 - 122,607,231 (+)Ensembl
GRCm38.p6 Ensembl6122,626,410 - 122,630,272 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123429   ⟹   ENSMUSP00000115252
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6122,603,712 - 122,607,231 (+)Ensembl
GRCm38.p6 Ensembl6122,626,753 - 122,630,272 (+)Ensembl
RefSeq Acc Id: NM_139218   ⟹   NP_631964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396122,603,383 - 122,607,230 (+)NCBI
GRCm386122,626,424 - 122,630,271 (+)NCBI
MGSCv376122,576,442 - 122,580,289 (+)RGD
Celera6124,426,164 - 124,430,002 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_631964   ⟸   NM_139218
- UniProtKB: Q8QZY3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062832   ⟸   ENSMUST00000049644
RefSeq Acc Id: ENSMUSP00000115252   ⟸   ENSMUST00000123429

Promoters
RGD ID:6890916
Promoter ID:EPDNEW_M8909
Type:multiple initiation site
Name:Dppa3_1
Description:Mus musculus developmental pluripotency-associated 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386122,626,420 - 122,626,480EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920958 AgrOrtholog
Ensembl Genes ENSMUSG00000046323 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000062832 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000115252 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049644 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000123429 UniProtKB/TrEMBL
InterPro Dppa3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73708 UniProtKB/Swiss-Prot
MGD MGI:1920958 ENTREZGENE
NCBI Gene 73708 ENTREZGENE
PANTHER PTHR31577 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PGC7_Stella UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dppa3 PhenoGen
UniProt DPPA3_MOUSE UniProtKB/Swiss-Prot
  K4DID3_MOUSE UniProtKB/TrEMBL
  Q8QZY3 ENTREZGENE
UniProt Secondary F6S6F5 UniProtKB/Swiss-Prot