SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25) - Rat Genome Database

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Gene: SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25) Homo sapiens
Analyze
Symbol: SNRNP25
Name: small nuclear ribonucleoprotein U11/U12 subunit 25
RGD ID: 1322103
HGNC Page HGNC:14161
Description: Predicted to be involved in RNA splicing. Located in cytosol; intercellular bridge; and nucleoplasm. Part of U12-type spliceosomal complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C16orf33; FLJ22940; minus-99 protein; small nuclear ribonucleoprotein 25kDa (U11/U12); small nuclear ribonucleoprotein, U11/U12 25kDa subunit; U11/U12 small nuclear ribonucleoprotein 25 kDa protein; U11/U12 snRNP 25 kDa protein; U11/U12 snRNP 25K
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,828 - 57,669 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,828 - 57,669 (+)EnsemblGRCh38hg38GRCh38
GRCh3716103,828 - 107,669 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361643,017 - 47,444 (+)NCBINCBI36Build 36hg18NCBI36
Build 341643,016 - 47,443NCBI
Celera16305,723 - 309,564 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef1622,220 - 26,061 (+)NCBIHuRef
CHM1_116103,765 - 107,606 (+)NCBICHM1_1
T2T-CHM13v2.01647,364 - 51,206 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15146077   PMID:15489334   PMID:15616553   PMID:16728641   PMID:18559850   PMID:21873635   PMID:22658674   PMID:23314748   PMID:25300797   PMID:25416956  
PMID:27609421   PMID:32296183   PMID:33961781   PMID:34373451   PMID:35271311   PMID:37866880  


Genomics

Comparative Map Data
SNRNP25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,828 - 57,669 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,828 - 57,669 (+)EnsemblGRCh38hg38GRCh38
GRCh3716103,828 - 107,669 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361643,017 - 47,444 (+)NCBINCBI36Build 36hg18NCBI36
Build 341643,016 - 47,443NCBI
Celera16305,723 - 309,564 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef1622,220 - 26,061 (+)NCBIHuRef
CHM1_116103,765 - 107,606 (+)NCBICHM1_1
T2T-CHM13v2.01647,364 - 51,206 (+)NCBIT2T-CHM13v2.0
Snrnp25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,155,415 - 32,158,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,155,415 - 32,158,984 (+)EnsemblGRCm39 Ensembl
GRCm381132,205,415 - 32,208,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,205,415 - 32,208,984 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,105,415 - 32,108,996 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,105,415 - 32,108,984 (+)NCBIMGSCv36mm8
Celera1134,622,491 - 34,626,091 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.82NCBI
Snrnp25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,924,932 - 15,928,279 (-)NCBIGRCr8
mRatBN7.21015,420,482 - 15,423,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,420,486 - 15,423,804 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,166,502 - 20,169,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,655,395 - 19,658,713 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,148,276 - 15,151,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,685,999 - 15,689,338 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,686,008 - 15,689,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,581,143 - 15,584,474 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,667,569 - 15,671,373 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,668,617 - 15,672,420 (-)NCBI
Celera1015,087,966 - 15,091,305 (-)NCBICelera
Cytogenetic Map10q12NCBI
Snrnp25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,098,487 - 17,101,497 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,098,487 - 17,101,497 (-)NCBIChiLan1.0ChiLan1.0
SNRNP25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218269,139 - 272,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,061,138 - 4,064,755 (+)NCBINHGRI_mPanPan1
PanPan1.11643,986 - 48,429 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1643,986 - 48,418 (+)Ensemblpanpan1.1panPan2
SNRNP25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,414,073 - 40,416,985 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,414,370 - 40,416,873 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,677,090 - 41,679,884 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,757,101 - 40,759,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,757,398 - 40,759,901 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,444,657 - 40,447,447 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,405,584 - 40,408,374 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,884,769 - 40,887,563 (-)NCBIUU_Cfam_GSD_1.0
Snrnp25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,712,563 - 112,715,425 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501805,861 - 813,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501810,423 - 813,273 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNRNP25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,568,041 - 41,571,642 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,568,030 - 41,571,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,865,594 - 40,869,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNRNP25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,643 - 14,514 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606831,210,403 - 31,215,573 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snrnp25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913934,846 - 937,790 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913934,950 - 937,782 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SNRNP25
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3(chr16:29941-2560460)x3 copy number gain See cases [RCV000052368] Chr16:29941..2560460 [GRCh38]
Chr16:79941..2610461 [GRCh37]
Chr16:19941..2550462 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46566-1800860)x3 copy number gain See cases [RCV000052369] Chr16:46566..1800860 [GRCh38]
Chr16:96566..1850861 [GRCh37]
Chr16:36566..1790862 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-3214623)x3 copy number gain See cases [RCV000052370] Chr16:46766..3214623 [GRCh38]
Chr16:96766..3264623 [GRCh37]
Chr16:36766..3204624 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-168972)x3 copy number gain See cases [RCV000052141] Chr16:46766..168972 [GRCh38]
Chr16:96766..218971 [GRCh37]
Chr16:36766..158971 [NCBI36]
Chr16:16p13.3		 uncertain significance
GRCh38/hg38 16p13.3(chr16:23141-1773349)x1 copy number loss See cases [RCV000053251] Chr16:23141..1773349 [GRCh38]
Chr16:73141..1823350 [GRCh37]
Chr16:13141..1763351 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:23141-1712523)x1 copy number loss See cases [RCV000053252] Chr16:23141..1712523 [GRCh38]
Chr16:73141..1762524 [GRCh37]
Chr16:13141..1702525 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1997582)x1 copy number loss See cases [RCV000053253] Chr16:46766..1997582 [GRCh38]
Chr16:96766..2047583 [GRCh37]
Chr16:36766..1987584 [NCBI36]
Chr16:16p13.3		 pathogenic
NM_024571.3(SNRNP25):c.82G>A (p.Glu28Lys) single nucleotide variant Malignant melanoma [RCV000071134] Chr16:55471 [GRCh38]
Chr16:105471 [GRCh37]
Chr16:45471 [NCBI36]
Chr16:16p13.3		 not provided
NM_022450.3(RHBDF1):c.2095A>G (p.Ser699Gly) single nucleotide variant Malignant melanoma [RCV000071149] Chr16:59027 [GRCh38]
Chr16:109025 [GRCh37]
Chr16:49025 [NCBI36]
Chr16:16p13.3		 not provided
NM_022450.3(RHBDF1):c.1870G>A (p.Glu624Lys) single nucleotide variant Malignant melanoma [RCV000071151] Chr16:59442 [GRCh38]
Chr16:109440 [GRCh37]
Chr16:49440 [NCBI36]
Chr16:16p13.3		 not provided
GRCh38/hg38 16p13.3(chr16:46766-80410)x1 copy number loss See cases [RCV000133616] Chr16:46766..80410 [GRCh38]
Chr16:96766..130409 [GRCh37]
Chr16:36766..70409 [NCBI36]
Chr16:16p13.3		 uncertain significance
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-1544014)x1 copy number loss See cases [RCV000134917] Chr16:46766..1544014 [GRCh38]
Chr16:96766..1594015 [GRCh37]
Chr16:36766..1534016 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-4247185)x3 copy number gain See cases [RCV000136687] Chr16:46766..4247185 [GRCh38]
Chr16:96766..4297186 [GRCh37]
Chr16:36766..4237187 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46722-1867327)x1 copy number loss See cases [RCV000137826] Chr16:46722..1867327 [GRCh38]
Chr16:96722..1917328 [GRCh37]
Chr16:36722..1857329 [NCBI36]
Chr16:16p13.3		 pathogenic
GRCh38/hg38 16p13.3(chr16:46766-882211)x1 copy number loss See cases [RCV000137979] Chr16:46766..882211 [GRCh38]
Chr16:96766..932211 [GRCh37]
Chr16:36766..872212 [NCBI36]
Chr16:16p13.3		 pathogenic|uncertain significance
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12		 pathogenic
GRCh38/hg38 16p13.3(chr16:16203-129081)x3 copy number gain See cases [RCV000140339] Chr16:16203..129081 [GRCh38]
Chr16:66203..179080 [GRCh37]
Chr16:6203..119080 [NCBI36]
Chr16:16p13.3		 benign
GRCh38/hg38 16p13.3(chr16:43722-308914)x3 copy number gain See cases [RCV000141393] Chr16:43722..308914 [GRCh38]
Chr16:93722..358914 [GRCh37]
Chr16:33722..298915 [NCBI36]
Chr16:16p13.3		 uncertain significance
GRCh38/hg38 16p13.3(chr16:35880-605262)x1 copy number loss See cases [RCV000143709] Chr16:35880..605262 [GRCh38]
Chr16:85880..655262 [GRCh37]
Chr16:25880..595263 [NCBI36]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3(chr16:97494-323799)x3 copy number gain Breast ductal adenocarcinoma [RCV000207213] Chr16:97494..323799 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:97494-1257060)x3 copy number gain Breast ductal adenocarcinoma [RCV000207237] Chr16:97494..1257060 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:88165-1715454)x1 copy number loss See cases [RCV000239415] Chr16:88165..1715454 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:72769-1511716)x1 copy number loss See cases [RCV000240294] Chr16:72769..1511716 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-754083)x1 copy number loss See cases [RCV000446474] Chr16:85880..754083 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:97133-109978)x3 copy number gain See cases [RCV000447150] Chr16:97133..109978 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3-13.2(chr16:78801-9169448) copy number gain See cases [RCV000446555] Chr16:78801..9169448 [GRCh37]
Chr16:16p13.3-13.2		 pathogenic
GRCh37/hg19 16p13.3(chr16:97133-5122974)x3 copy number gain See cases [RCV000445663] Chr16:97133..5122974 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:106859-735154)x3 copy number gain See cases [RCV000511218] Chr16:106859..735154 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-643107)x1 copy number loss See cases [RCV000510746] Chr16:85880..643107 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-13.2(chr16:85880-9883129)x3 copy number gain See cases [RCV000510698] Chr16:85880..9883129 [GRCh37]
Chr16:16p13.3-13.2		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-546267)x3 copy number gain See cases [RCV000512217] Chr16:85880..546267 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-3216551)x3 copy number gain not provided [RCV000683742] Chr16:85880..3216551 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1875694)x1 copy number loss not provided [RCV000683741] Chr16:85880..1875694 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1498731)x1 copy number loss not provided [RCV000683740] Chr16:85880..1498731 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-147965)x1 copy number loss not provided [RCV000683738] Chr16:85880..147965 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3-13.13(chr16:85880-11209288)x3 copy number gain not provided [RCV000683743] Chr16:85880..11209288 [GRCh37]
Chr16:16p13.3-13.13		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-294656)x1 copy number loss not provided [RCV000683739] Chr16:85880..294656 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:84451-152220)x1 copy number loss not provided [RCV000738916] Chr16:84451..152220 [GRCh37]
Chr16:16p13.3		 benign
GRCh37/hg19 16p13.3(chr16:61451-1593645)x1 copy number loss not provided [RCV000751445] Chr16:61451..1593645 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-111198)x3 copy number gain not provided [RCV000849502] Chr16:85880..111198 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-830613)x1 copy number loss not provided [RCV000846660] Chr16:85880..830613 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-2053328)x1 copy number loss not provided [RCV000849039] Chr16:85880..2053328 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1166355)x1 copy number loss not provided [RCV001006741] Chr16:85880..1166355 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1468459)x1 copy number loss not provided [RCV000848130] Chr16:85880..1468459 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:106989-293949)x1 copy number loss not provided [RCV002473487] Chr16:106989..293949 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:84485-5251013)x3 copy number gain not provided [RCV001537890] Chr16:84485..5251013 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_97132)_(193701_?)del deletion not provided [RCV001031918] Chr16:97132..193701 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:106988-735154)x3 copy number gain not provided [RCV001006742] Chr16:106988..735154 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85880-5249457)x3 copy number gain not provided [RCV001259749] Chr16:85880..5249457 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-754083) copy number loss not specified [RCV002052499] Chr16:85880..754083 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:85880-1468828) copy number loss not specified [RCV002052500] Chr16:85880..1468828 [GRCh37]
Chr16:16p13.3		 pathogenic
NC_000016.9:g.(?_97132)_(163851_?)del deletion not provided [RCV001963099] Chr16:97132..163851 [GRCh37]
Chr16:16p13.3		 pathogenic
GRCh37/hg19 16p13.3(chr16:96766-137939)x1 copy number loss See cases [RCV002246174] Chr16:96766..137939 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85881-1350186)x1 copy number loss not provided [RCV002474576] Chr16:85881..1350186 [GRCh37]
Chr16:16p13.3		 pathogenic
NM_024571.4(SNRNP25):c.290C>T (p.Thr97Met) single nucleotide variant Inborn genetic diseases [RCV002991129] Chr16:56589 [GRCh38]
Chr16:106589 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.260A>G (p.Tyr87Cys) single nucleotide variant Inborn genetic diseases [RCV002684838] Chr16:56559 [GRCh38]
Chr16:106559 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.50T>C (p.Leu17Pro) single nucleotide variant Inborn genetic diseases [RCV002869251] Chr16:55466 [GRCh38]
Chr16:105466 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.98C>T (p.Thr33Met) single nucleotide variant Inborn genetic diseases [RCV002978858] Chr16:55514 [GRCh38]
Chr16:105514 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.247G>C (p.Val83Leu) single nucleotide variant Inborn genetic diseases [RCV002719129] Chr16:56546 [GRCh38]
Chr16:106546 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.112A>G (p.Lys38Glu) single nucleotide variant Inborn genetic diseases [RCV003217701] Chr16:55528 [GRCh38]
Chr16:105528 [GRCh37]
Chr16:16p13.3		 uncertain significance
NM_024571.4(SNRNP25):c.136G>A (p.Val46Met) single nucleotide variant Inborn genetic diseases [RCV003346847] Chr16:55779 [GRCh38]
Chr16:105779 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85881-470832)x1 copy number loss not provided [RCV003483254] Chr16:85881..470832 [GRCh37]
Chr16:16p13.3		 uncertain significance
GRCh37/hg19 16p13.3(chr16:85881-1657611)x1 copy number loss not provided [RCV003483253] Chr16:85881..1657611 [GRCh37]
Chr16:16p13.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1662
Count of miRNA genes:694
Interacting mature miRNAs:780
Transcripts:ENST00000293861, ENST00000383018, ENST00000397876, ENST00000417493, ENST00000466183, ENST00000481947, ENST00000493672
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
ECD00252  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,103 - 106,022UniSTSGRCh37
GRCh3716105,103 - 106,045UniSTSGRCh37
Build 361645,103 - 46,022RGDNCBI36
Celera16306,997 - 307,939UniSTS
Celera16306,997 - 307,916RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,494 - 24,436UniSTS
HuRef1623,494 - 24,413UniSTS
ECD01032  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,984 - 107,864UniSTSGRCh37
Build 361646,984 - 47,864RGDNCBI36
Celera16308,879 - 309,759RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,376 - 26,256UniSTS
ECD01733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,087 - 106,942UniSTSGRCh37
Build 361646,087 - 46,942RGDNCBI36
Celera16307,981 - 308,836RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,478 - 25,333UniSTS
ECD06052  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,483 - 104,202UniSTSGRCh37
Build 361643,483 - 44,202RGDNCBI36
Celera16305,377 - 306,096RGD
Cytogenetic Map16p13.3UniSTS
HuRef1621,874 - 22,593UniSTS
REN94495  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716102,844 - 103,074UniSTSGRCh37
Build 361642,844 - 43,074RGDNCBI36
Celera16304,737 - 304,967RGD
Cytogenetic Map16p13.3UniSTS
HuRef1621,234 - 21,464UniSTS
REN94496  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,067 - 103,335UniSTSGRCh37
Build 361643,067 - 43,335RGDNCBI36
Celera16304,960 - 305,228RGD
Cytogenetic Map16p13.3UniSTS
HuRef1621,457 - 21,725UniSTS
REN94497  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,313 - 103,551UniSTSGRCh37
Build 361643,313 - 43,551RGDNCBI36
Celera16305,206 - 305,445RGD
Cytogenetic Map16p13.3UniSTS
HuRef1621,703 - 21,942UniSTS
REN94498  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,529 - 103,773UniSTSGRCh37
Build 361643,529 - 43,773RGDNCBI36
Celera16305,423 - 305,667RGD
Cytogenetic Map16p13.3UniSTS
HuRef1621,920 - 22,164UniSTS
REN94499  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,751 - 104,018UniSTSGRCh37
Build 361643,751 - 44,018RGDNCBI36
Celera16305,645 - 305,912RGD
Cytogenetic Map16p13.3UniSTS
HuRef1622,142 - 22,409UniSTS
REN94500  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,998 - 104,251UniSTSGRCh37
Build 361643,998 - 44,251RGDNCBI36
Celera16305,892 - 306,145RGD
Cytogenetic Map16p13.3UniSTS
HuRef1622,389 - 22,642UniSTS
REN94501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716104,045 - 104,275UniSTSGRCh37
Build 361644,045 - 44,275RGDNCBI36
Celera16305,939 - 306,169RGD
Cytogenetic Map16p13.3UniSTS
HuRef1622,436 - 22,666UniSTS
REN94502  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716104,419 - 104,659UniSTSGRCh37
Build 361644,419 - 44,659RGDNCBI36
Celera16306,313 - 306,553RGD
Cytogenetic Map16p13.3UniSTS
HuRef1622,810 - 23,050UniSTS
REN94503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716104,664 - 104,901UniSTSGRCh37
Build 361644,664 - 44,901RGDNCBI36
Celera16306,558 - 306,795RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,055 - 23,292UniSTS
REN94504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716104,802 - 105,026UniSTSGRCh37
Build 361644,802 - 45,026RGDNCBI36
Celera16306,696 - 306,920RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,193 - 23,417UniSTS
REN94505  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,001 - 105,240UniSTSGRCh37
Build 361645,001 - 45,240RGDNCBI36
Celera16306,895 - 307,134RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,392 - 23,631UniSTS
REN94506  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,217 - 105,458UniSTSGRCh37
Build 361645,217 - 45,458RGDNCBI36
Celera16307,111 - 307,352RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,608 - 23,849UniSTS
REN94507  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,435 - 105,678UniSTSGRCh37
Build 361645,435 - 45,678RGDNCBI36
Celera16307,329 - 307,572RGD
Cytogenetic Map16p13.3UniSTS
HuRef1623,826 - 24,069UniSTS
REN94508  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,631 - 105,896UniSTSGRCh37
Build 361645,631 - 45,896RGDNCBI36
Celera16307,525 - 307,790RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,022 - 24,287UniSTS
REN94509  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,876 - 106,108UniSTSGRCh37
Build 361645,876 - 46,108RGDNCBI36
Celera16307,770 - 308,002RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,267 - 24,499UniSTS
REN94510  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,087 - 106,333UniSTSGRCh37
Build 361646,087 - 46,333RGDNCBI36
Celera16307,981 - 308,227RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,478 - 24,724UniSTS
REN94511  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,309 - 106,565UniSTSGRCh37
Build 361646,309 - 46,565RGDNCBI36
Celera16308,203 - 308,459RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,700 - 24,956UniSTS
REN94512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,514 - 106,772UniSTSGRCh37
Build 361646,514 - 46,772RGDNCBI36
Celera16308,408 - 308,666RGD
Cytogenetic Map16p13.3UniSTS
HuRef1624,905 - 25,163UniSTS
REN94513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,751 - 107,010UniSTSGRCh37
Build 361646,751 - 47,010RGDNCBI36
Celera16308,645 - 308,905RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,142 - 25,402UniSTS
REN94514  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,992 - 107,248UniSTSGRCh37
Build 361646,992 - 47,248RGDNCBI36
Celera16308,887 - 309,143RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,384 - 25,640UniSTS
REN94515  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716107,222 - 107,476UniSTSGRCh37
Build 361647,222 - 47,476RGDNCBI36
Celera16309,117 - 309,371RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,614 - 25,868UniSTS
REN94516  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716107,456 - 107,708UniSTSGRCh37
Build 361647,456 - 47,708RGDNCBI36
Celera16309,351 - 309,603RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,848 - 26,100UniSTS
REN94517  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716107,654 - 107,905UniSTSGRCh37
Build 361647,654 - 47,905RGDNCBI36
Celera16309,549 - 309,800RGD
Cytogenetic Map16p13.3UniSTS
HuRef1626,046 - 26,297UniSTS
REN94518  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716107,875 - 108,130UniSTSGRCh37
Build 361647,875 - 48,130RGDNCBI36
Celera16309,770 - 310,026RGD
Cytogenetic Map16p13.3UniSTS
HuRef1626,267 - 26,523UniSTS
stSG608830  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716103,941 - 105,317UniSTSGRCh37
Build 361643,941 - 45,317RGDNCBI36
Celera16305,835 - 307,211RGD
HuRef1622,332 - 23,708UniSTS
stSG608831  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716105,298 - 106,391UniSTSGRCh37
Build 361645,298 - 46,391RGDNCBI36
Celera16307,192 - 308,285RGD
HuRef1623,689 - 24,782UniSTS
stSG608832  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716106,373 - 107,396UniSTSGRCh37
Build 361646,373 - 47,396RGDNCBI36
Celera16308,267 - 309,291RGD
HuRef1624,764 - 25,788UniSTS
D16S3332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3716107,215 - 107,355UniSTSGRCh37
Build 361647,215 - 47,355RGDNCBI36
Celera16309,110 - 309,250RGD
Cytogenetic Map16p13.3UniSTS
HuRef1625,607 - 25,747UniSTS
TNG Radiation Hybrid Map16127.0UniSTS
GeneMap99-G3 RH Map160.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2331 2195 1603 512 1207 356 3663 2123 3693 380 1407 1468 171 1 1055 2436 3 2
Low 108 796 123 112 744 109 694 74 41 39 53 145 4 149 352 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000293861   ⟹   ENSP00000293861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,828 - 57,669 (+)Ensembl
RefSeq Acc Id: ENST00000383018   ⟹   ENSP00000372482
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,829 - 57,668 (+)Ensembl
RefSeq Acc Id: ENST00000397876   ⟹   ENSP00000380974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,887 - 57,372 (+)Ensembl
RefSeq Acc Id: ENST00000417493   ⟹   ENSP00000391289
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,899 - 56,613 (+)Ensembl
RefSeq Acc Id: ENST00000466183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1654,960 - 57,444 (+)Ensembl
RefSeq Acc Id: ENST00000481947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1655,495 - 57,453 (+)Ensembl
RefSeq Acc Id: ENST00000493672
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,899 - 55,871 (+)Ensembl
RefSeq Acc Id: ENST00000710415   ⟹   ENSP00000518261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1653,828 - 57,669 (+)Ensembl
RefSeq Acc Id: NM_024571   ⟹   NP_078847
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381653,828 - 57,669 (+)NCBI
GRCh3716103,829 - 107,669 (+)RGD
Build 361643,017 - 47,444 (+)NCBI Archive
Celera16305,723 - 309,564 (+)RGD
HuRef1622,220 - 26,061 (+)ENTREZGENE
CHM1_116103,765 - 107,606 (+)NCBI
T2T-CHM13v2.01647,364 - 51,206 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_078847   ⟸   NM_024571
- UniProtKB: Q4TT61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000293861   ⟸   ENST00000293861
RefSeq Acc Id: ENSP00000391289   ⟸   ENST00000417493
RefSeq Acc Id: ENSP00000380974   ⟸   ENST00000397876
RefSeq Acc Id: ENSP00000372482   ⟸   ENST00000383018
RefSeq Acc Id: ENSP00000518261   ⟸   ENST00000710415
Protein Domains
SNRNP25 ubiquitin-like   Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BV90-F1-model_v2 AlphaFold Q9BV90 1-132 view protein structure

Promoters
RGD ID:6793468
Promoter ID:HG_KWN:22551
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000293861,   OTTHUMT00000134189,   OTTHUMT00000318417,   OTTHUMT00000318418
Position:
Human AssemblyChrPosition (strand)Source
Build 361643,081 - 43,632 (+)MPROMDB
RGD ID:7230703
Promoter ID:EPDNEW_H21097
Type:initiation region
Name:SNRNP25_2
Description:small nuclear ribonucleoprotein U11/U12 subunit 25
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21099  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381653,107 - 53,167EPDNEW
RGD ID:7230707
Promoter ID:EPDNEW_H21099
Type:initiation region
Name:SNRNP25_1
Description:small nuclear ribonucleoprotein U11/U12 subunit 25
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21097  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381653,841 - 53,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:14161 AgrOrtholog
COSMIC SNRNP25 COSMIC
Ensembl Genes ENSG00000161981 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000293861 ENTREZGENE
  ENST00000293861.8 UniProtKB/TrEMBL
  ENST00000397876.6 UniProtKB/TrEMBL
  ENST00000417493.1 UniProtKB/TrEMBL
  ENST00000710415.1 UniProtKB/TrEMBL
GTEx ENSG00000161981 GTEx
HGNC ID HGNC:14161 ENTREZGENE
Human Proteome Map SNRNP25 Human Proteome Map
InterPro SNRNP25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNRNP25_ubiquitin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_dom UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin_dom UniProtKB/Swiss-Prot
KEGG Report hsa:79622 UniProtKB/Swiss-Prot
NCBI Gene 79622 ENTREZGENE
PANTHER PTHR14942 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ubiquitin_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164726099 PharmGKB
PROSITE UBIQUITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AA34QW04_HUMAN UniProtKB/TrEMBL
  B8ZZ06_HUMAN UniProtKB/TrEMBL
  H7BYR9_HUMAN UniProtKB/TrEMBL
  Q4TT61 ENTREZGENE, UniProtKB/TrEMBL
  Q9BV90 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q1W6H3 UniProtKB/Swiss-Prot
  Q6IEF8 UniProtKB/Swiss-Prot
  Q9H5W4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 SNRNP25  small nuclear ribonucleoprotein U11/U12 subunit 25  SNRNP25  small nuclear ribonucleoprotein, U11/U12 25kDa subunit  Symbol and/or name change 5135510 APPROVED
2015-11-10 SNRNP25  small nuclear ribonucleoprotein, U11/U12 25kDa subunit  SNRNP25  small nuclear ribonucleoprotein 25kDa (U11/U12)  Symbol and/or name change 5135510 APPROVED
2011-07-27 SNRNP25  small nuclear ribonucleoprotein 25kDa (U11/U12)  C16orf33  chromosome 16 open reading frame 33  Symbol and/or name change 5135510 APPROVED