SCML4 (Scm polycomb group protein like 4) - Rat Genome Database
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Gene: SCML4 (Scm polycomb group protein like 4) Homo sapiens
Analyze
Symbol: SCML4
Name: Scm polycomb group protein like 4
RGD ID: 1322066
HGNC Page HGNC
Description: Predicted to have chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to localize to nucleus; INTERACTS WITH aflatoxin B1; all-trans-retinoic acid; antirheumatic drug.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dJ47M23.1; FLJ36252; sex comb on midleg like 4; sex comb on midleg like 4 (Drosophila); sex comb on midleg-like 4 (Drosophila); sex comb on midleg-like protein 4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6107,702,154 - 107,824,317 (-)EnsemblGRCh38hg38GRCh38
GRCh386107,697,297 - 107,845,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376108,023,361 - 108,145,521 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,146,342 - 108,200,148 (-)NCBINCBI36hg18NCBI36
Celera6108,771,904 - 108,892,338 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6105,594,303 - 105,714,955 (-)NCBIHuRef
CHM1_16108,286,061 - 108,408,072 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:18978678   PMID:21873635   PMID:26186194   PMID:28514442   PMID:29472232   PMID:32296183  


Genomics

Comparative Map Data
SCML4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6107,702,154 - 107,824,317 (-)EnsemblGRCh38hg38GRCh38
GRCh386107,697,297 - 107,845,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376108,023,361 - 108,145,521 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366108,146,342 - 108,200,148 (-)NCBINCBI36hg18NCBI36
Celera6108,771,904 - 108,892,338 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6105,594,303 - 105,714,955 (-)NCBIHuRef
CHM1_16108,286,061 - 108,408,072 (-)NCBICHM1_1
Scml4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391042,736,314 - 42,836,778 (+)NCBIGRCm39mm39
GRCm381042,858,077 - 42,960,782 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1042,860,370 - 42,960,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371042,580,318 - 42,680,588 (+)NCBIGRCm37mm9NCBIm37
MGSCv361042,549,132 - 42,649,195 (+)NCBImm8
Celera1043,727,280 - 43,828,323 (+)NCBICelera
Cytogenetic Map10B2NCBI
Scml4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02047,596,531 - 47,689,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2047,596,575 - 47,689,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02049,258,704 - 49,350,697 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42046,771,530 - 46,864,100 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12046,798,632 - 46,889,789 (+)NCBI
Celera2053,538,104 - 53,629,929 (-)NCBICelera
Cytogenetic Map20q13NCBI
Scml4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541132,940,367 - 33,036,779 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541132,940,367 - 33,036,779 (-)NCBIChiLan1.0ChiLan1.0
SCML4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16109,379,532 - 109,498,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6109,379,532 - 109,498,016 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06105,517,185 - 105,633,576 (-)NCBIMhudiblu_PPA_v0panPan3
SCML4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1264,851,740 - 64,945,496 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11264,851,495 - 64,937,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Scml4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365644,042,148 - 4,144,950 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCML4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl173,838,813 - 73,968,699 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1173,838,808 - 73,982,634 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2183,160,076 - 83,253,479 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCML4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11366,034,219 - 66,165,842 (+)NCBI
ChlSab1.1 Ensembl1366,034,792 - 66,156,205 (+)Ensembl
Scml4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478014,516,123 - 14,575,762 (+)NCBI

Position Markers
D6S941  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q21UniSTS
Marshfield Genetic Map6112.2UniSTS
Marshfield Genetic Map6112.2RGD
SHGC-82258  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,108,635 - 108,108,972UniSTSGRCh37
Build 366108,215,328 - 108,215,665RGDNCBI36
Celera6108,855,423 - 108,855,760RGD
Cytogenetic Map6q21UniSTS
HuRef6105,677,871 - 105,678,208UniSTS
TNG Radiation Hybrid Map652127.0UniSTS
SHGC-146199  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,127,353 - 108,127,651UniSTSGRCh37
Build 366108,234,046 - 108,234,344RGDNCBI36
Celera6108,874,178 - 108,874,477RGD
Cytogenetic Map6q21UniSTS
HuRef6105,696,783 - 105,697,082UniSTS
TNG Radiation Hybrid Map652131.0UniSTS
TKY1995  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376108,145,612 - 108,145,783UniSTSGRCh37
Celera6108,892,429 - 108,892,600UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2515
Count of miRNA genes:956
Interacting mature miRNAs:1164
Transcripts:ENST00000369020, ENST00000369021, ENST00000369022, ENST00000369025, ENST00000426221, ENST00000440927, ENST00000459992, ENST00000463507, ENST00000473515, ENST00000476798, ENST00000479803
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 71 75 13 1 243 1 13 2 14
Low 883 884 1088 384 1177 316 728 85 441 117 756 1081 68 519 258 1
Below cutoff 1388 1808 577 218 315 124 3122 1860 2885 219 553 297 94 684 2260 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001743305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB072902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL024507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL512490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL512592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE349472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG767121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ834612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR975586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC410126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000369020   ⟹   ENSP00000358016
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,702,154 - 107,824,313 (-)Ensembl
RefSeq Acc Id: ENST00000369021   ⟹   ENSP00000358017
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,718,954 - 107,772,251 (-)Ensembl
RefSeq Acc Id: ENST00000369022   ⟹   ENSP00000358018
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,704,104 - 107,824,317 (-)Ensembl
RefSeq Acc Id: ENST00000369025   ⟹   ENSP00000358021
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,704,651 - 107,732,395 (-)Ensembl
RefSeq Acc Id: ENST00000426221   ⟹   ENSP00000395589
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,740,065 - 107,824,286 (-)Ensembl
RefSeq Acc Id: ENST00000440927   ⟹   ENSP00000404688
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,744,949 - 107,772,251 (-)Ensembl
RefSeq Acc Id: ENST00000459992
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,719,730 - 107,772,251 (-)Ensembl
RefSeq Acc Id: ENST00000463507
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,720,671 - 107,824,294 (-)Ensembl
RefSeq Acc Id: ENST00000473515
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,718,955 - 107,824,312 (-)Ensembl
RefSeq Acc Id: ENST00000476798
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,718,445 - 107,732,103 (-)Ensembl
RefSeq Acc Id: ENST00000479803
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6107,720,709 - 107,744,054 (-)Ensembl
RefSeq Acc Id: NM_001286408   ⟹   NP_001273337
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,702,154 - 107,824,313 (-)NCBI
HuRef6105,594,300 - 105,714,955 (-)NCBI
CHM1_16108,286,061 - 108,408,072 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286409   ⟹   NP_001273338
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,702,154 - 107,732,150 (-)NCBI
HuRef6105,594,300 - 105,714,955 (-)NCBI
CHM1_16108,286,061 - 108,316,300 (-)NCBI
Sequence:
RefSeq Acc Id: NM_198081   ⟹   NP_932347
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,702,154 - 107,824,313 (-)NCBI
GRCh376108,023,361 - 108,145,521 (-)NCBI
Build 366108,146,342 - 108,200,148 (-)NCBI Archive
Celera6108,771,904 - 108,892,338 (-)RGD
HuRef6105,594,300 - 105,714,955 (-)NCBI
CHM1_16108,286,061 - 108,408,072 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535703   ⟹   XP_011534005
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535704   ⟹   XP_011534006
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,772,260 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535706   ⟹   XP_011534008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535707   ⟹   XP_011534009
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,718,955 - 107,824,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535709   ⟹   XP_011534011
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,737,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535710   ⟹   XP_011534012
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,746,846 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010677   ⟹   XP_016866166
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,601 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010678   ⟹   XP_016866167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010679   ⟹   XP_016866168
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,039 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010680   ⟹   XP_016866169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,845,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010681   ⟹   XP_016866170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,812,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010682   ⟹   XP_016866171
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,705,193 - 107,824,604 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010683   ⟹   XP_016866172
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010684   ⟹   XP_016866173
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,718,955 - 107,824,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010685   ⟹   XP_016866174
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,601 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010686   ⟹   XP_016866175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010687   ⟹   XP_016866176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,697,297 - 107,824,602 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010688   ⟹   XP_016866177
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,743,943 - 107,824,610 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001743305
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,707,924 - 107,824,606 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273337 (Get FASTA)   NCBI Sequence Viewer  
  NP_001273338 (Get FASTA)   NCBI Sequence Viewer  
  NP_932347 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534005 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534006 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534008 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534009 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534011 (Get FASTA)   NCBI Sequence Viewer  
  XP_011534012 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866166 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866167 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866168 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866169 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866170 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866171 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866172 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866173 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866174 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866175 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866176 (Get FASTA)   NCBI Sequence Viewer  
  XP_016866177 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH33286 (Get FASTA)   NCBI Sequence Viewer  
  BAB84951 (Get FASTA)   NCBI Sequence Viewer  
  BAC04198 (Get FASTA)   NCBI Sequence Viewer  
  BAG64585 (Get FASTA)   NCBI Sequence Viewer  
  CAH05521 (Get FASTA)   NCBI Sequence Viewer  
  EAW48393 (Get FASTA)   NCBI Sequence Viewer  
  EAW48394 (Get FASTA)   NCBI Sequence Viewer  
  EAW48395 (Get FASTA)   NCBI Sequence Viewer  
  EAW48396 (Get FASTA)   NCBI Sequence Viewer  
  Q8N228 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_932347   ⟸   NM_198081
- Peptide Label: isoform a
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot),   B4E0X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273337   ⟸   NM_001286408
- Peptide Label: isoform b
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273338   ⟸   NM_001286409
- Peptide Label: isoform c
- UniProtKB: A0A0B4J1S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011534005   ⟸   XM_011535703
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011534008   ⟸   XM_011535706
- Peptide Label: isoform X4
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011534006   ⟸   XM_011535704
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011534012   ⟸   XM_011535710
- Peptide Label: isoform X12
- UniProtKB: A0A0B4J1S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011534011   ⟸   XM_011535709
- Peptide Label: isoform X12
- UniProtKB: A0A0B4J1S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011534009   ⟸   XM_011535707
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_016866169   ⟸   XM_017010680
- Peptide Label: isoform X2
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866171   ⟸   XM_017010682
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016866176   ⟸   XM_017010687
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016866174   ⟸   XM_017010685
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016866166   ⟸   XM_017010677
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016866175   ⟸   XM_017010686
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016866167   ⟸   XM_017010678
- Peptide Label: isoform X2
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866172   ⟸   XM_017010683
- Peptide Label: isoform X4
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866168   ⟸   XM_017010679
- Peptide Label: isoform X2
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866170   ⟸   XM_017010681
- Peptide Label: isoform X2
- UniProtKB: Q8N228 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866173   ⟸   XM_017010684
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_016866177   ⟸   XM_017010688
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: ENSP00000395589   ⟸   ENST00000426221
RefSeq Acc Id: ENSP00000404688   ⟸   ENST00000440927
RefSeq Acc Id: ENSP00000358021   ⟸   ENST00000369025
RefSeq Acc Id: ENSP00000358018   ⟸   ENST00000369022
RefSeq Acc Id: ENSP00000358016   ⟸   ENST00000369020
RefSeq Acc Id: ENSP00000358017   ⟸   ENST00000369021
Protein Domains
RBR   SAM   SLED

Promoters
RGD ID:7208827
Promoter ID:EPDNEW_H10159
Type:initiation region
Name:SCML4_1
Description:sex comb on midleg like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386107,732,150 - 107,732,210EPDNEW
RGD ID:6804781
Promoter ID:HG_KWN:54534
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_2Hour
Transcripts:UC003PRY.2,   UC010KDG.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366108,159,751 - 108,160,251 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001286408.1(SCML4):c.-18-18052C>T single nucleotide variant Lung cancer [RCV000096424] Chr6:107767865 [GRCh38]
Chr6:108089069 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh38/hg38 6q21(chr6:107010730-108039165)x3 copy number gain See cases [RCV000135360] Chr6:107010730..108039165 [GRCh38]
Chr6:107331934..108360369 [GRCh37]
Chr6:107438627..108467062 [NCBI36]
Chr6:6q21		 uncertain significance
GRCh38/hg38 6q16.3-21(chr6:102356502-111049879)x1 copy number loss See cases [RCV000134806] Chr6:102356502..111049879 [GRCh38]
Chr6:102804377..111371082 [GRCh37]
Chr6:102911070..111477775 [NCBI36]
Chr6:6q16.3-21		 pathogenic
GRCh38/hg38 6q21-22.1(chr6:107370141-115827482)x1 copy number loss See cases [RCV000138006] Chr6:107370141..115827482 [GRCh38]
Chr6:107691345..116148646 [GRCh37]
Chr6:107798038..116255339 [NCBI36]
Chr6:6q21-22.1		 pathogenic
GRCh38/hg38 6q16.1-22.31(chr6:96609994-122161548)x1 copy number loss See cases [RCV000139465] Chr6:96609994..122161548 [GRCh38]
Chr6:97057870..122482694 [GRCh37]
Chr6:97164591..122524393 [NCBI36]
Chr6:6q16.1-22.31		 pathogenic
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3 copy number gain See cases [RCV000139729] Chr6:74382807..142040500 [GRCh38]
Chr6:75092523..142361637 [GRCh37]
Chr6:75149243..142403330 [NCBI36]
Chr6:6q13-24.1		 pathogenic
GRCh38/hg38 6q21(chr6:107445281-110547907)x1 copy number loss See cases [RCV000141382] Chr6:107445281..110547907 [GRCh38]
Chr6:107766485..110869110 [GRCh37]
Chr6:107873178..110975803 [NCBI36]
Chr6:6q21		 pathogenic
GRCh38/hg38 6q21-22.31(chr6:106503719-125781219)x1 copy number loss See cases [RCV000141587] Chr6:106503719..125781219 [GRCh38]
Chr6:106951594..126102365 [GRCh37]
Chr6:107058287..126144058 [NCBI36]
Chr6:6q21-22.31		 pathogenic
GRCh38/hg38 6q16.3-21(chr6:103279465-113934239)x1 copy number loss See cases [RCV000142287] Chr6:103279465..113934239 [GRCh38]
Chr6:103727340..114255403 [GRCh37]
Chr6:103834033..114362096 [NCBI36]
Chr6:6q16.3-21		 pathogenic
GRCh38/hg38 6q16.3-22.31(chr6:100054889-120488154)x1 copy number loss See cases [RCV000143227] Chr6:100054889..120488154 [GRCh38]
Chr6:100502765..120809300 [GRCh37]
Chr6:100609486..120850999 [NCBI36]
Chr6:6q16.3-22.31		 pathogenic
GRCh37/hg19 6q21(chr6:107446437-108543388)x3 copy number gain See cases [RCV000446442] Chr6:107446437..108543388 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q14.3-22.31(chr6:85988428-120548687)x1 copy number loss See cases [RCV000445666] Chr6:85988428..120548687 [GRCh37]
Chr6:6q14.3-22.31		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q16.1-21(chr6:97384446-110247755)x1 copy number loss See cases [RCV000510703] Chr6:97384446..110247755 [GRCh37]
Chr6:6q16.1-21		 pathogenic
GRCh37/hg19 6q21(chr6:107662992-108276358)x3 copy number gain See cases [RCV000512331] Chr6:107662992..108276358 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q16.1-21(chr6:94202605-109878834)x1 copy number loss See cases [RCV000512470] Chr6:94202605..109878834 [GRCh37]
Chr6:6q16.1-21		 pathogenic
GRCh37/hg19 6q21(chr6:107947938-108184564)x1 copy number loss not provided [RCV000682705] Chr6:107947938..108184564 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6q16.1-22.1(chr6:95549951-116684929)x1 copy number loss not provided [RCV000682693] Chr6:95549951..116684929 [GRCh37]
Chr6:6q16.1-22.1		 pathogenic
Single allele deletion not provided [RCV000677972] Chr6:107174371..107825273 [GRCh38]
Chr6:107388471..108146477 [GRCh37]
Chr6:6q21		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q21(chr6:108030627-108032450)x0 copy number loss not provided [RCV000745965] Chr6:108030627..108032450 [GRCh37]
Chr6:6q21		 benign
GRCh37/hg19 6q21(chr6:108031708-108032450)x0 copy number loss not provided [RCV000745966] Chr6:108031708..108032450 [GRCh37]
Chr6:6q21		 benign
GRCh37/hg19 6q21(chr6:108031708-108033181)x0 copy number loss not provided [RCV000745967] Chr6:108031708..108033181 [GRCh37]
Chr6:6q21		 benign
NM_198081.5(SCML4):c.995C>T (p.Ala332Val) single nucleotide variant not provided [RCV000969517] Chr6:107707990 [GRCh38]
Chr6:108029194 [GRCh37]
Chr6:6q21		 benign
GRCh37/hg19 6q21(chr6:107925558-108220556)x3 copy number gain not provided [RCV000846219] Chr6:107925558..108220556 [GRCh37]
Chr6:6q21		 uncertain significance
NM_198081.5(SCML4):c.1056G>A (p.Val352=) single nucleotide variant not provided [RCV000882648] Chr6:107707929 [GRCh38]
Chr6:108029133 [GRCh37]
Chr6:6q21		 benign
GRCh37/hg19 6q16.3-22.1(chr6:101296547-117004249)x3 copy number gain Microcephaly [RCV001251053] Chr6:101296547..117004249 [GRCh37]
Chr6:6q16.3-22.1		 pathogenic
GRCh37/hg19 6q16.1-21(chr6:98949950-114533905)x1 copy number loss Deletion 6q16 q21 [RCV001263224] Chr6:98949950..114533905 [GRCh37]
Chr6:6q16.1-21		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21397 AgrOrtholog
COSMIC SCML4 COSMIC
Ensembl Genes ENSG00000146285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000358016 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358017 UniProtKB/Swiss-Prot
  ENSP00000358018 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358021 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000395589 UniProtKB/TrEMBL
  ENSP00000404688 UniProtKB/TrEMBL
Ensembl Transcript ENST00000369020 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369021 UniProtKB/Swiss-Prot
  ENST00000369022 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369025 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000426221 UniProtKB/TrEMBL
  ENST00000440927 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1380.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000146285 GTEx
HGNC ID HGNC:21397 ENTREZGENE
Human Proteome Map SCML4 Human Proteome Map
InterPro SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCML2_RBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLED_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:256380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 256380 ENTREZGENE
Pfam RBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134946179 PharmGKB
SMART SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.486109 ENTREZGENE
  Hs.587364 ENTREZGENE
UniProt A0A0B4J1S9 ENTREZGENE, UniProtKB/TrEMBL
  B4E0X3 ENTREZGENE, UniProtKB/TrEMBL
  F2Z2X1_HUMAN UniProtKB/TrEMBL
  Q5T0T5_HUMAN UniProtKB/TrEMBL
  Q8N228 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B0QZ10 UniProtKB/Swiss-Prot
  B0QZ11 UniProtKB/Swiss-Prot
  B7ZBX3 UniProtKB/Swiss-Prot
  Q5JXD0 UniProtKB/Swiss-Prot
  Q5T0T6 UniProtKB/Swiss-Prot
  Q8IYY6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-27 SCML4  Scm polycomb group protein like 4    sex comb on midleg like 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED
2017-02-28 SCML4  sex comb on midleg like 4 (Drosophila)    sex comb on midleg-like 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED