Gpr22 (G protein-coupled receptor 22) - Rat Genome Database

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Gene: Gpr22 (G protein-coupled receptor 22) Mus musculus
Analyze
Symbol: Gpr22
Name: G protein-coupled receptor 22
RGD ID: 1321988
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to hormone stimulus. Predicted to act upstream of or within cell projection organization and signal transduction. Predicted to be located in plasma membrane. Is expressed in adrenal gland; gut; heart; and nervous system. Orthologous to human GPR22 (G protein-coupled receptor 22).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2900068K05Rik; AW061316; G-protein coupled receptor 22; MGC107197; probable G-protein coupled receptor 22
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391231,756,866 - 31,763,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1231,756,866 - 31,763,946 (-)EnsemblGRCm39 Ensembl
GRCm381231,706,867 - 31,713,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,706,867 - 31,713,947 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,391,732 - 32,398,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,292,114 - 32,299,126 (-)NCBIMGSCv36mm8
Celera1233,156,802 - 33,163,861 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12679517   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18287559   PMID:18539757  
PMID:19521566   PMID:21677750   PMID:21873635   PMID:24194600   PMID:27626380   PMID:34321999  


Genomics

Comparative Map Data
Gpr22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391231,756,866 - 31,763,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1231,756,866 - 31,763,946 (-)EnsemblGRCm39 Ensembl
GRCm381231,706,867 - 31,713,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1231,706,867 - 31,713,947 (-)EnsemblGRCm38mm10GRCm38
MGSCv371232,391,732 - 32,398,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361232,292,114 - 32,299,126 (-)NCBIMGSCv36mm8
Celera1233,156,802 - 33,163,861 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1213.69NCBI
GPR22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387107,470,057 - 107,477,845 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7107,470,018 - 107,475,684 (+)EnsemblGRCh38hg38GRCh38
GRCh377107,110,502 - 107,116,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367106,897,738 - 106,903,361 (+)NCBINCBI36Build 36hg18NCBI36
Build 347106,708,456 - 106,709,758NCBI
Celera7101,915,775 - 101,921,399 (+)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef7101,471,125 - 101,476,749 (+)NCBIHuRef
CHM1_17107,044,440 - 107,050,064 (+)NCBICHM1_1
T2T-CHM13v2.07108,786,096 - 108,792,223 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27106,471,589 - 106,477,213 (+)NCBI
Gpr22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8654,037,998 - 54,044,994 (-)NCBIGRCr8
mRatBN7.2648,309,619 - 48,317,864 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl648,310,505 - 48,317,486 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx648,617,978 - 48,624,964 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0648,932,905 - 48,939,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0648,373,105 - 48,380,092 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0651,012,421 - 51,021,253 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl651,011,426 - 51,019,407 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0659,683,765 - 59,690,751 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4649,654,472 - 49,661,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1649,658,794 - 49,664,434 (-)NCBI
Celera647,513,122 - 47,520,109 (-)NCBICelera
Cytogenetic Map6q16NCBI
Gpr22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541011,841,850 - 11,849,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541011,841,813 - 11,849,441 (+)NCBIChiLan1.0ChiLan1.0
GPR22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26144,312,793 - 144,330,792 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17192,582,764 - 192,600,760 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0799,448,716 - 99,457,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17112,172,710 - 112,178,596 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7112,176,800 - 112,178,101 (+)Ensemblpanpan1.1panPan2
GPR22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11813,124,646 - 13,131,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1813,126,050 - 13,127,351 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1812,767,612 - 12,774,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01813,395,100 - 13,402,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1813,394,815 - 13,402,207 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11813,211,989 - 13,219,203 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01813,131,913 - 13,139,129 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01813,409,432 - 13,416,648 (-)NCBIUU_Cfam_GSD_1.0
Gpr22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511855,494,990 - 55,502,094 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647916,618,680 - 16,624,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647916,620,222 - 16,625,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9107,205,411 - 107,211,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19107,202,301 - 107,211,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29117,960,272 - 117,965,933 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12176,390,051 - 76,397,224 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2176,395,039 - 76,396,340 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604227,474,580 - 27,480,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473922,261,383 - 22,267,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473922,262,177 - 22,269,220 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr22
148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:816
Count of miRNA genes:472
Interacting mature miRNAs:563
Transcripts:ENSMUST00000057783, ENSMUST00000174480, ENSMUST00000176710
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse

Markers in Region
AW061316  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381231,708,687 - 31,708,836UniSTSGRCm38
MGSCv371232,393,552 - 32,393,701UniSTSGRCm37
Celera1233,158,622 - 33,158,771UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map12A2UniSTS
Whitehead/MRC_RH12306.98UniSTS
Gpr22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A3UniSTS
cM Map1213.69UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000057783   ⟹   ENSMUSP00000056125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1231,756,866 - 31,763,925 (-)Ensembl
GRCm38.p6 Ensembl1231,706,867 - 31,713,926 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174480   ⟹   ENSMUSP00000134674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1231,759,448 - 31,763,932 (-)Ensembl
GRCm38.p6 Ensembl1231,709,449 - 31,713,933 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176710   ⟹   ENSMUSP00000134839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1231,758,711 - 31,763,946 (-)Ensembl
GRCm38.p6 Ensembl1231,708,712 - 31,713,947 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236002   ⟹   ENSMUSP00000158030
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1231,756,872 - 31,763,925 (-)Ensembl
GRCm38.p6 Ensembl1231,706,873 - 31,713,926 (-)Ensembl
RefSeq Acc Id: NM_175191   ⟹   NP_780400
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391231,756,866 - 31,763,882 (-)NCBI
GRCm381231,706,867 - 31,713,883 (-)NCBI
MGSCv371232,391,732 - 32,398,791 (-)RGD
Celera1233,156,802 - 33,163,861 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_780400   ⟸   NM_175191
- UniProtKB: Q8BZL4 (UniProtKB/Swiss-Prot),   Q80UE1 (UniProtKB/Swiss-Prot),   G3X9C3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158030   ⟸   ENSMUST00000236002
RefSeq Acc Id: ENSMUSP00000134674   ⟸   ENSMUST00000174480
RefSeq Acc Id: ENSMUSP00000134839   ⟸   ENSMUST00000176710
RefSeq Acc Id: ENSMUSP00000056125   ⟸   ENSMUST00000057783
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BZL4-F1-model_v2 AlphaFold Q8BZL4 1-432 view protein structure

Promoters
RGD ID:8678098
Promoter ID:EPDNEW_M17080
Type:initiation region
Name:Gpr22_1
Description:Mus musculus G protein-coupled receptor 22 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381231,713,880 - 31,713,940EPDNEW
RGD ID:6823038
Promoter ID:MM_KWN:11445
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000057783
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361232,398,441 - 32,398,941 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920260 AgrOrtholog
Ensembl Genes ENSMUSG00000044067 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057783 ENTREZGENE
  ENSMUST00000057783.6 UniProtKB/Swiss-Prot
  ENSMUST00000174480.3 UniProtKB/TrEMBL
  ENSMUST00000176710.2 UniProtKB/Swiss-Prot
  ENSMUST00000236002.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73010 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920260 ENTREZGENE
NCBI Gene 73010 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEDIUM-WAVE-SENSITIVE OPSIN 1-RELATED UniProtKB/TrEMBL
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPSIN UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr22 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UZX5_MOUSE UniProtKB/TrEMBL
  G3X9C3 ENTREZGENE, UniProtKB/TrEMBL
  GPR22_MOUSE UniProtKB/Swiss-Prot
  Q80UE1 ENTREZGENE
  Q8BXB7_MOUSE UniProtKB/TrEMBL
  Q8BZL4 ENTREZGENE
UniProt Secondary Q80UE1 UniProtKB/Swiss-Prot