Gpr132 (G protein-coupled receptor 132) - Rat Genome Database

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Gene: Gpr132 (G protein-coupled receptor 132) Mus musculus
Analyze
Symbol: Gpr132
Name: G protein-coupled receptor 132
RGD ID: 1321938
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor activity. Involved in negative regulation of G2/M transition of mitotic cell cycle. Acts upstream of or within G1/S transition of mitotic cell cycle. Predicted to be located in plasma membrane. Is expressed in cerebral cortex; long bone epiphyseal plate; and thymus primordium. Used to study autoimmune disease. Orthologous to human GPR132 (G protein-coupled receptor 132).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor G2A; G2; G2 accumulation protein; G2a; probable G-protein coupled receptor 132
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,814,493 - 112,832,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,814,493 - 112,831,848 (-)EnsemblGRCm39 Ensembl
GRCm3812112,850,873 - 112,868,416 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,850,873 - 112,868,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,089,087 - 114,099,127 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,299,312 - 113,308,700 (-)NCBIMGSCv36mm8
Celera12114,061,219 - 114,071,162 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9770487   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11371358   PMID:12086852   PMID:12477932   PMID:12482833   PMID:14681556   PMID:15383458   PMID:15665078  
PMID:15728718   PMID:15834123   PMID:15927955   PMID:16141072   PMID:16141073   PMID:16378626   PMID:16602821   PMID:16990555   PMID:17255525   PMID:18821587   PMID:18824544   PMID:19106413  
PMID:19135725   PMID:19164809   PMID:19521566   PMID:21267068   PMID:21297111   PMID:21677750   PMID:21873635   PMID:22560297   PMID:23293064   PMID:23393303   PMID:24210353   PMID:24478334  
PMID:24862038   PMID:26410627   PMID:27402702   PMID:27692066   PMID:28049847   PMID:29159784   PMID:30139917   PMID:30327654   PMID:30530591   PMID:32708184   PMID:33941654   PMID:34504016  
PMID:35149052   PMID:36437247   PMID:37435068  


Genomics

Comparative Map Data
Gpr132
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,814,493 - 112,832,035 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,814,493 - 112,831,848 (-)EnsemblGRCm39 Ensembl
GRCm3812112,850,873 - 112,868,416 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,850,873 - 112,868,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,089,087 - 114,099,127 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,299,312 - 113,308,700 (-)NCBIMGSCv36mm8
Celera12114,061,219 - 114,071,162 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.25NCBI
GPR132
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,049,395 - 105,065,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,049,395 - 105,065,445 (-)EnsemblGRCh38hg38GRCh38
GRCh3714105,515,732 - 105,531,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,586,782 - 104,602,799 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414104,586,782 - 104,602,799NCBI
Celera1485,569,212 - 85,585,228 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,709,317 - 85,725,273 (-)NCBIHuRef
CHM1_114105,453,498 - 105,469,670 (-)NCBICHM1_1
T2T-CHM13v2.01499,293,953 - 99,309,986 (-)NCBIT2T-CHM13v2.0
Gpr132
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,745,142 - 137,763,037 (-)NCBIGRCr8
mRatBN7.26131,924,061 - 131,943,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,924,160 - 131,942,168 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6132,094,202 - 132,105,837 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,384,468 - 132,395,772 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,758,844 - 131,770,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,652,213 - 137,671,658 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,652,213 - 137,664,133 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,648,352 - 146,666,965 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,851,214 - 137,856,343 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16137,857,413 - 137,875,338 (-)NCBI
Celera6129,462,704 - 129,474,240 (-)NCBICelera
Cytogenetic Map6q32NCBI
Gpr132
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,366,333 - 3,382,778 (-)NCBIChiLan1.0ChiLan1.0
GPR132
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215106,234,265 - 106,260,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,450,767 - 105,467,313 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,697,589 - 85,716,764 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,482,545 - 105,498,527 (-)NCBIpanpan1.1PanPan1.1panPan2
GPR132
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,478,585 - 72,493,165 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,479,905 - 72,493,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,991,394 - 72,005,339 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,767,070 - 72,781,032 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,765,336 - 72,779,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,446,021 - 72,461,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,490,585 - 72,506,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,886,899 - 72,902,565 (-)NCBIUU_Cfam_GSD_1.0
Gpr132
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,599,131 - 1,611,702 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936621428,332 - 442,283 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR132
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27131,287,616 - 131,303,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR132
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,964,828 - 82,979,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605370,396,513 - 70,414,890 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr132
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734351,220 - 374,603 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr132
471 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:496
Count of miRNA genes:323
Interacting mature miRNAs:367
Transcripts:ENSMUST00000021729
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse
13524846Ppiq11_mprepulse inhibition QTL 11 (mouse)1282666396116666396Mouse
1301492Dbsty3_mdiabesity 3 (mouse)Not determined1283532075117532224Mouse
1301879Insq10_minsulin QTL 10 (mouse)Not determined1283532075117532224Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
10412156Nociq3_mnociceptive sensitivity inflammatory QTL 3 (mouse)Not determined1286396075114831653Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
1300545Lifespan3_mlife span 3 (mouse)Not determined1288052874120092757Mouse
1301308Prdt4_mprion disease incubation time 4 (mouse)Not determined1288308354120092757Mouse
5491194Mobq3_mmultigenic obesity QTL 3 (mouse)Not determined1289664071120092757Mouse
1301836Heal5_mwound healing/regeneration 5 (mouse)Not determined1289939031120092757Mouse
1301922Bbaa6_mB.burgdorferi-associated arthritis 6 (mouse)Not determined1290308268120092757Mouse
10402491Dipa4_mdrug induced psychomotor activation 4 (mouse)Not determined1291222515120092757Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1300973Abmm_mantibody mediated myocarditis (mouse)Not determined1293264461120092757Mouse
1302177Dps2_mdelta power in slow-wave sleep 2 (mouse)Not determined1294146064120092757Mouse
1302138Im6_mimmunoregulatory 6 (mouse)Not determined1296860337120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
10412075Nils1_mneointima lesion size 1 (mouse)Not determined12102024665120092757Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse
1558957Igan4_mIgA nephropathy 4 (mouse)Not determined12109750025119024949Mouse
15092085Igly2_mIgG glycosylation 2, GP14 (mouse)12111737297119992757Mouse

Markers in Region
BB208670  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812112,851,009 - 112,851,116UniSTSGRCm38
MGSCv3712114,089,220 - 114,089,327UniSTSGRCm37
Celera12114,061,352 - 114,061,459UniSTS
Cytogenetic Map12F2UniSTS
Whitehead/MRC_RH121050.34UniSTS
Gpr132  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3712114,090,449 - 114,091,077UniSTSGRCm37
Celera12114,062,568 - 114,063,196UniSTS
Cytogenetic Map12F2UniSTS
cM Map12 UniSTS
Gpr132  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3812112,852,238 - 112,852,866UniSTSGRCm38
MGSCv3712114,090,449 - 114,091,077UniSTSGRCm37
Celera12114,062,568 - 114,063,196UniSTS
Cytogenetic Map12F2UniSTS
cM Map12 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021729   ⟹   ENSMUSP00000021729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,814,493 - 112,824,572 (-)Ensembl
GRCm38.p6 Ensembl12112,850,873 - 112,860,952 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222776   ⟹   ENSMUSP00000152509
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12112,816,767 - 112,831,848 (-)Ensembl
GRCm38.p6 Ensembl12112,853,147 - 112,868,228 (-)Ensembl
RefSeq Acc Id: NM_019925   ⟹   NP_064309
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,814,496 - 112,824,536 (-)NCBI
GRCm3812112,850,876 - 112,860,916 (-)NCBI
MGSCv3712114,089,087 - 114,099,127 (-)RGD
Celera12114,061,219 - 114,071,162 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516102   ⟹   XP_006516165
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,814,493 - 112,832,035 (-)NCBI
GRCm3812112,850,873 - 112,868,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006516103   ⟹   XP_006516166
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912112,814,493 - 112,820,725 (-)NCBI
GRCm3812112,850,873 - 112,857,105 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_064309   ⟸   NM_019925
- UniProtKB: Q0VBS4 (UniProtKB/Swiss-Prot),   Q3U5A4 (UniProtKB/Swiss-Prot),   Q9Z282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516165   ⟸   XM_006516102
- Peptide Label: isoform X1
- UniProtKB: Q0VBS4 (UniProtKB/Swiss-Prot),   Q3U5A4 (UniProtKB/Swiss-Prot),   Q9Z282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006516166   ⟸   XM_006516103
- Peptide Label: isoform X1
- UniProtKB: Q0VBS4 (UniProtKB/Swiss-Prot),   Q3U5A4 (UniProtKB/Swiss-Prot),   Q9Z282 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000152509   ⟸   ENSMUST00000222776
RefSeq Acc Id: ENSMUSP00000021729   ⟸   ENSMUST00000021729

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z282-F1-model_v2 AlphaFold Q9Z282 1-382 view protein structure

Promoters
RGD ID:8679402
Promoter ID:EPDNEW_M17732
Type:initiation region
Name:Gpr132_1
Description:Mus musculus G protein-coupled receptor 132 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812112,860,931 - 112,860,991EPDNEW
RGD ID:6823037
Promoter ID:MM_KWN:12888
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_019925
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3612114,098,711 - 114,100,062 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890220 AgrOrtholog
Ensembl Genes ENSMUSG00000021298 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021729 ENTREZGENE
  ENSMUST00000021729.9 UniProtKB/Swiss-Prot
  ENSMUST00000222776.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro G2A_lysphc_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:56696 UniProtKB/Swiss-Prot
MGD MGI:1890220 ENTREZGENE
NCBI Gene 56696 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 132-RELATED UniProtKB/Swiss-Prot
  LYSOPHOSPHATIDIC ACID RECEPTOR 5/SPHINGOSYLPHOSPHORYLCHOLINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Gpr132 PhenoGen
PRINTS G2ARECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A1Y7VNN0_MOUSE UniProtKB/TrEMBL
  GP132_MOUSE UniProtKB/Swiss-Prot
  Q0VBS4 ENTREZGENE
  Q3U5A4 ENTREZGENE
  Q9Z282 ENTREZGENE
UniProt Secondary Q0VBS4 UniProtKB/Swiss-Prot
  Q3U5A4 UniProtKB/Swiss-Prot