Lancl2 (LanC (bacterial lantibiotic synthetase component C)-like 2) - Rat Genome Database

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Gene: Lancl2 (LanC (bacterial lantibiotic synthetase component C)-like 2) Mus musculus
Analyze
Symbol: Lancl2
Name: LanC (bacterial lantibiotic synthetase component C)-like 2
RGD ID: 1321927
MGI Page MGI
Description: Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of abscisic acid-activated signaling pathway. Predicted to be located in cortical actin cytoskeleton; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; lung; male reproductive gland or organ; nervous system; and sensory organ. Orthologous to human LANCL2 (LanC like glutathione S-transferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700003F10Rik; lanC-like protein 2; testis-specific adriamycin sensitivity protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39657,679,440 - 57,716,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl657,679,525 - 57,716,424 (+)EnsemblGRCm39 Ensembl
GRCm38657,702,455 - 57,739,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl657,702,540 - 57,739,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37657,652,449 - 57,689,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36657,632,214 - 57,668,060 (+)NCBIMGSCv36mm8
Celera658,446,120 - 58,483,175 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16944949   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22042223   PMID:22794259   PMID:24194600   PMID:26426291   PMID:26839965   PMID:27626380   PMID:27871880   PMID:27933891   PMID:27936058   PMID:28106097   PMID:29880530  
PMID:30068389   PMID:30196744   PMID:31996711   PMID:32591558   PMID:33601422   PMID:33932340   PMID:34098144   PMID:35736456   PMID:36834900  


Genomics

Comparative Map Data
Lancl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39657,679,440 - 57,716,434 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl657,679,525 - 57,716,424 (+)EnsemblGRCm39 Ensembl
GRCm38657,702,455 - 57,739,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl657,702,540 - 57,739,439 (+)EnsemblGRCm38mm10GRCm38
MGSCv37657,652,449 - 57,689,443 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36657,632,214 - 57,668,060 (+)NCBIMGSCv36mm8
Celera658,446,120 - 58,483,175 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
LANCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,365,337 - 55,433,737 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl755,365,337 - 55,433,737 (+)EnsemblGRCh38hg38GRCh38
GRCh37755,433,030 - 55,501,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,400,635 - 55,468,929 (+)NCBINCBI36Build 36hg18NCBI36
Build 34755,207,349 - 55,275,644NCBI
Celera755,536,348 - 55,604,629 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef755,268,359 - 55,336,642 (+)NCBIHuRef
CHM1_1755,435,807 - 55,504,119 (+)NCBICHM1_1
T2T-CHM13v2.0755,525,667 - 55,594,061 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2755,437,426 - 55,505,717 (+)NCBI
Lancl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8488,771,974 - 88,813,920 (-)NCBIGRCr8
mRatBN7.2487,441,821 - 87,483,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,441,823 - 87,482,800 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx492,665,021 - 92,704,609 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,440,426 - 88,480,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0486,803,501 - 86,843,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,524,212 - 88,565,113 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,525,695 - 88,565,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,346,850 - 153,387,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,197,364 - 87,236,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1487,439,372 - 87,480,274 (-)NCBI
Celera482,209,185 - 82,248,518 (-)NCBICelera
Cytogenetic Map4q24NCBI
Lancl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955456204,434 - 229,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955456204,434 - 250,143 (-)NCBIChiLan1.0ChiLan1.0
LANCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2660,198,037 - 60,264,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17108,522,754 - 108,589,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,958,850 - 56,025,166 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1756,268,426 - 56,335,549 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl756,268,426 - 56,335,549 (+)Ensemblpanpan1.1panPan2
LANCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1186,131,536 - 6,237,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl186,197,989 - 6,234,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha186,035,458 - 6,082,375 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0186,232,306 - 6,279,253 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl186,231,806 - 6,280,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1186,222,155 - 6,269,095 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0186,196,304 - 6,243,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0186,302,518 - 6,349,674 (+)NCBIUU_Cfam_GSD_1.0
Lancl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,623,089 - 109,672,284 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678219,991 - 265,627 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936678217,272 - 268,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LANCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1848,550,944 - 48,593,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11848,550,752 - 48,593,055 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LANCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,435,435 - 3,503,802 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,434,909 - 3,501,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606219,087,225 - 19,155,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lancl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740485,874 - 514,638 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740487,173 - 514,484 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lancl2
1148 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:614
Count of miRNA genes:306
Interacting mature miRNAs:342
Transcripts:ENSMUST00000050077, ENSMUST00000072954, ENSMUST00000151042, ENSMUST00000153777
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64444280571096451Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4870349075424693Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000050077   ⟹   ENSMUSP00000052146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl657,679,621 - 57,715,467 (+)Ensembl
GRCm38.p6 Ensembl657,702,636 - 57,738,482 (+)Ensembl
RefSeq Acc Id: ENSMUST00000072954   ⟹   ENSMUSP00000072723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl657,679,525 - 57,716,424 (+)Ensembl
GRCm38.p6 Ensembl657,702,540 - 57,739,439 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153777   ⟹   ENSMUSP00000121377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl657,680,072 - 57,716,423 (+)Ensembl
GRCm38.p6 Ensembl657,703,087 - 57,739,438 (+)Ensembl
RefSeq Acc Id: NM_133737   ⟹   NP_598498
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39657,679,440 - 57,716,434 (+)NCBI
GRCm38657,702,455 - 57,739,449 (+)ENTREZGENE
MGSCv37657,652,449 - 57,689,443 (+)RGD
Celera658,446,120 - 58,483,175 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_598498   ⟸   NM_133737
- UniProtKB: Q9JJK2 (UniProtKB/Swiss-Prot),   F6RJV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000072723   ⟸   ENSMUST00000072954
RefSeq Acc Id: ENSMUSP00000121377   ⟸   ENSMUST00000153777
RefSeq Acc Id: ENSMUSP00000052146   ⟸   ENSMUST00000050077

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJK2-F1-model_v2 AlphaFold Q9JJK2 1-450 view protein structure

Promoters
RGD ID:6839550
Promoter ID:MM_KWN:46161
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B6
Transcripts:ENSMUST00000072954,   NM_133737,   NM_133737_LANCL2,   OTTMUST00000056285
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36657,652,826 - 57,653,326 (+)MPROMDB
RGD ID:6889844
Promoter ID:EPDNEW_M8373
Type:initiation region
Name:Lancl2_1
Description:Mus musculus LanC -like 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38657,702,503 - 57,702,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919085 AgrOrtholog
Ensembl Genes ENSMUSG00000062190 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050077 ENTREZGENE
  ENSMUST00000050077.15 UniProtKB/Swiss-Prot
  ENSMUST00000072954.8 UniProtKB/Swiss-Prot
  ENSMUST00000153777.2 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6hp_glycosidase-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANC-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LanC-like_prot_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71835 UniProtKB/Swiss-Prot
MGD MGI:1919085 ENTREZGENE
NCBI Gene 71835 ENTREZGENE
PANTHER LANC-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANC-LIKE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LANC_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lancl2 PhenoGen
PRINTS LANCEUKARYTE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LANCSUPER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LANC_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP LanC-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F6RJV6 ENTREZGENE, UniProtKB/TrEMBL
  LANC2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE