Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of LANCL2 mRNA | CTD | PMID:28960355 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of LANCL2 mRNA | CTD | PMID:17942748 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to LANCL2 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LANCL2 mRNA | CTD | PMID:32109520 | 2,6-dinitrotoluene | affects expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of LANCL2 mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LANCL2 mRNA | CTD | PMID:30851411 | 2-methylcholine | affects expression | ISO | LANCL2 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of LANCL2 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of LANCL2 protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of LANCL2 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of LANCL2 protein | CTD | PMID:34186270 | 5-aza-2'-deoxycytidine | affects expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Decitabine affects the expression of LANCL2 mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | increases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of LANCL2 mRNA | CTD | PMID:30047161 and PMID:36843608 | acrylamide | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of LANCL2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of LANCL2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | LANCL2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of LANCL2 gene | CTD | PMID:27153756 | amitrole | increases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of LANCL2 mRNA | CTD | PMID:30047161 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of LANCL2 mRNA | CTD | PMID:19770486 and PMID:21715664 | benzo[a]pyrene | affects methylation | ISO | LANCL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of LANCL2 exon | CTD | PMID:27901495 | benzo[a]pyrene | decreases methylation | ISO | LANCL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LANCL2 promoter | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of LANCL2 mRNA | CTD | PMID:25181051 more ... | bisphenol A | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of LANCL2 protein | CTD | PMID:34186270 | bisphenol A | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of LANCL2 protein | CTD | PMID:31675489 | Bisphenol B | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of LANCL2 protein | CTD | PMID:34186270 | bisphenol F | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of LANCL2 protein | CTD | PMID:34186270 | CGP 52608 | multiple interactions | ISO | LANCL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LANCL2 gene] | CTD | PMID:28238834 | cisplatin | affects expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of LANCL2 mRNA | CTD | PMID:23300844 | cisplatin | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of LANCL2 mRNA | CTD | PMID:27392435 and PMID:27594783 | cisplatin | multiple interactions | ISO | LANCL2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of LANCL2 mRNA | CTD | PMID:27392435 | cyclosporin A | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of LANCL2 mRNA | CTD | PMID:27989131 | diethyl maleate | decreases expression | EXP | | 6480464 | diethyl maleate results in decreased expression of LANCL2 mRNA | CTD | PMID:25270620 | entinostat | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of LANCL2 mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | LANCL2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LANCL2 protein | CTD | PMID:23301498 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of LANCL2 mRNA | CTD | PMID:30319688 | fipronil | decreases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of LANCL2 mRNA | CTD | PMID:34044035 | flutamide | decreases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of LANCL2 mRNA | CTD | PMID:24793618 | ivermectin | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of LANCL2 protein | CTD | PMID:32959892 | mercury atom | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Mercury results in decreased expression of LANCL2 mRNA | CTD | PMID:19937285 | mercury(0) | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Mercury results in decreased expression of LANCL2 mRNA | CTD | PMID:19937285 | methimazole | increases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of LANCL2 mRNA | CTD | PMID:30047161 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of LANCL2 mRNA | CTD | PMID:18502557 | methotrexate | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of LANCL2 mRNA | CTD | PMID:24449571 | methylmercury chloride | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of LANCL2 mRNA | CTD | PMID:28001369 | oxaliplatin | multiple interactions | ISO | Lancl2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of LANCL2 mRNA | CTD | PMID:25729387 | paracetamol | decreases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of LANCL2 mRNA | CTD | PMID:33387578 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LANCL2 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of LANCL2 mRNA | CTD | PMID:18301758 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of LANCL2 mRNA | CTD | PMID:22698814 | rac-lactic acid | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of LANCL2 mRNA | CTD | PMID:30851411 | sulfadimethoxine | increases expression | ISO | Lancl2 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of LANCL2 mRNA | CTD | PMID:30047161 | topotecan | multiple interactions | ISO | Lancl2 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of LANCL2 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of LANCL2 mRNA | CTD | PMID:24935251 and PMID:28542535 | trichostatin A | affects expression | ISO | LANCL2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of LANCL2 mRNA | CTD | PMID:28542535 | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of LANCL2 mRNA | CTD | PMID:33045310 | tunicamycin | increases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of LANCL2 mRNA | CTD | PMID:29453283 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of LANCL2 mRNA | CTD | PMID:21427059 | valproic acid | affects expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LANCL2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | LANCL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LANCL2 mRNA | CTD | PMID:23179753 more ... | |