Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SIX2 (SIX homeobox 2) Homo sapiens
Symbol: SIX2
Name: SIX homeobox 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in cell migration; cell population proliferation; and kidney development. Predicted to localize to nuclear chromatin and transcription factor complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeobox protein SIX2; sine oculis homeobox homolog 2
Mus musculus (house mouse) : Six2 (sine oculis-related homeobox 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Six2 (SIX homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Six2 (SIX homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIX2 (SIX homeobox 2)
Canis lupus familiaris (dog) : SIX2 (SIX homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Six2 (SIX homeobox 2)
Sus scrofa (pig) : SIX2 (SIX homeobox 2)
Chlorocebus sabaeus (African green monkey) : SIX2 (SIX homeobox 2)
Heterocephalus glaber (naked mole-rat) : Six2 (SIX homeobox 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl245,005,182 - 45,009,452 (-)EnsemblGRCh38hg38GRCh38
GRCh38245,005,182 - 45,009,645 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37245,232,324 - 45,236,580 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36245,085,847 - 45,090,026 (-)NCBINCBI36hg18NCBI36
Build 34245,143,994 - 45,148,173NCBI
Celera245,070,945 - 45,075,163 (-)NCBI
Cytogenetic Map2p21NCBI
HuRef244,969,941 - 44,974,159 (-)NCBIHuRef
CHM1_1245,162,931 - 45,167,149 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SIX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321897
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.