GSTO2 (glutathione S-transferase omega 2) - Rat Genome Database

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Gene: GSTO2 (glutathione S-transferase omega 2) Homo sapiens
Analyze
Symbol: GSTO2
Name: glutathione S-transferase omega 2
RGD ID: 1321858
HGNC Page HGNC
Description: Exhibits glutathione dehydrogenase (ascorbate) activity and identical protein binding activity. Involved in L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and xenobiotic metabolic process. Localizes to extracellular exosome. Implicated in Alzheimer's disease; Parkinson's disease; and asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bA127L20.1; bA127L20.1 (novel glutathione-S-transferase); glutathione S-transferase omega 2-2; glutathione S-transferase omega-2; glutathione-dependent dehydroascorbate reductase; glutathione-S-transferase-like protein; GSTO 2-2; GSTO-2; MMA(V) reductase; monomethylarsonic acid reductase
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10104,268,873 - 104,304,950 (+)EnsemblGRCh38hg38GRCh38
GRCh3810104,267,626 - 104,304,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710106,028,942 - 106,064,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,018,621 - 106,049,166 (+)NCBINCBI36hg18NCBI36
Celera1099,769,465 - 99,799,992 (+)NCBI
Cytogenetic Map10q25.1NCBI
HuRef1099,660,411 - 99,690,935 (+)NCBIHuRef
CHM1_110106,312,517 - 106,343,025 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12618591   PMID:14702039   PMID:15040808   PMID:15159516   PMID:15164054   PMID:15489334   PMID:15942673   PMID:15970797   PMID:15992993   PMID:16385451  
PMID:16761626   PMID:16788846   PMID:17207965   PMID:17505575   PMID:17601350   PMID:17978102   PMID:18065725   PMID:18398695   PMID:18414634   PMID:18427999   PMID:18941778   PMID:18977241  
PMID:18986335   PMID:19056867   PMID:19152805   PMID:19430957   PMID:19513904   PMID:19635583   PMID:19686770   PMID:19731014   PMID:19859803   PMID:19913121   PMID:19914269   PMID:20045512  
PMID:20113212   PMID:20200426   PMID:20210239   PMID:20367187   PMID:20379614   PMID:20472488   PMID:20547570   PMID:20628086   PMID:20800603   PMID:21094982   PMID:21113667   PMID:21518482  
PMID:21873635   PMID:22040239   PMID:22494505   PMID:22522127   PMID:22876127   PMID:23079717   PMID:23086268   PMID:23649768   PMID:23927022   PMID:24040330   PMID:24471578   PMID:25416956  
PMID:25491248   PMID:25716313   PMID:25726706   PMID:25835968   PMID:25892883   PMID:25910212   PMID:26103006   PMID:26344197   PMID:27221910   PMID:28017238   PMID:28514442   PMID:29323258  
PMID:30224590   PMID:30389161   PMID:30417762   PMID:31515488   PMID:31738399   PMID:32296183  


Genomics

Comparative Map Data
GSTO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10104,268,873 - 104,304,950 (+)EnsemblGRCh38hg38GRCh38
GRCh3810104,267,626 - 104,304,950 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710106,028,942 - 106,064,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610106,018,621 - 106,049,166 (+)NCBINCBI36hg18NCBI36
Celera1099,769,465 - 99,799,992 (+)NCBI
Cytogenetic Map10q25.1NCBI
HuRef1099,660,411 - 99,690,935 (+)NCBIHuRef
CHM1_110106,312,517 - 106,343,025 (+)NCBICHM1_1
Gsto2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,853,879 - 47,874,747 (+)NCBIGRCm39mm39
GRCm39 Ensembl1947,853,973 - 47,874,763 (+)Ensembl
GRCm381947,865,438 - 47,886,308 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,865,534 - 47,886,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371947,940,284 - 47,960,795 (+)NCBIGRCm37mm9NCBIm37
MGSCv361947,919,114 - 47,939,616 (+)NCBImm8
Celera1948,626,289 - 48,646,818 (+)NCBICelera
Cytogenetic Map19D1NCBI
Gsto2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21246,731,314 - 246,757,592 (+)NCBI
Rnor_6.0 Ensembl1267,607,416 - 267,640,455 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1271,229,036 - 271,243,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01267,617,517 - 267,640,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01275,050,163 - 275,072,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01278,656,945 - 278,671,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41253,239,392 - 253,275,110 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11253,504,135 - 253,539,851 (+)NCBI
Celera1242,496,974 - 242,517,641 (+)NCBICelera
Cytogenetic Map1q54NCBI
GSTO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110104,326,174 - 104,357,604 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10104,326,175 - 104,357,604 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010100,868,109 - 100,901,013 (+)NCBIMhudiblu_PPA_v0panPan3
GSTO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12816,580,250 - 16,604,977 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2816,586,777 - 16,604,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2816,752,960 - 16,777,367 (+)NCBI
ROS_Cfam_1.02817,058,781 - 17,083,140 (+)NCBI
UMICH_Zoey_3.12816,606,330 - 16,630,694 (+)NCBI
UNSW_CanFamBas_1.02816,635,026 - 16,659,336 (+)NCBI
UU_Cfam_GSD_1.02816,773,733 - 16,798,027 (+)NCBI
Gsto2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,304,171 - 30,322,114 (-)NCBI
SpeTri2.0NW_0049366001,907,396 - 1,925,256 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100152209
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14115,217,879 - 115,251,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114115,218,179 - 115,242,377 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214125,187,089 - 125,209,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSTO2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1997,319,695 - 97,348,406 (+)NCBI
ChlSab1.1 Ensembl997,325,215 - 97,349,422 (+)Ensembl
Vero_WHO_p1.0NW_02366604858,438,455 - 58,468,894 (+)NCBI

Position Markers
SHGC-23899  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710106,048,684 - 106,048,828UniSTSGRCh37
Build 3610106,038,674 - 106,038,818RGDNCBI36
Celera1099,789,501 - 99,789,645RGD
Cytogenetic Map10q25.1UniSTS
HuRef1099,680,443 - 99,680,587UniSTS
TNG Radiation Hybrid Map1050819.0UniSTS
STS-N37090  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710106,058,967 - 106,059,098UniSTSGRCh37
Build 3610106,048,957 - 106,049,088RGDNCBI36
Celera1099,799,783 - 99,799,914RGD
Cytogenetic Map10q25.1UniSTS
HuRef1099,690,726 - 99,690,857UniSTS
GeneMap99-GB4 RH Map10480.57UniSTS
SHGC-56827  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710106,028,236 - 106,028,447UniSTSGRCh37
Build 3610106,018,226 - 106,018,437RGDNCBI36
Celera1099,769,070 - 99,769,281RGD
Cytogenetic Map10q25.1UniSTS
HuRef1099,660,016 - 99,660,227UniSTS
TNG Radiation Hybrid Map1050829.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3702
Count of miRNA genes:1182
Interacting mature miRNAs:1446
Transcripts:ENST00000338595, ENST00000369707, ENST00000401888, ENST00000429569, ENST00000450629, ENST00000467629, ENST00000473401, ENST00000477078, ENST00000498052
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 86 475 7 1 10 639 273 50 534 261 280
Low 1344 1172 1090 463 593 302 2149 478 3327 307 878 1269 170 203 1604 3
Below cutoff 1002 1812 158 152 1342 152 1566 1715 113 59 40 77 1001 904 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_023363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001191013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001191014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001191015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_183239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK094412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK126230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL162742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL831850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY191318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY209189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY350731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM708208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC341647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000338595   ⟹   ENSP00000345023
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,269,184 - 104,304,950 (+)Ensembl
RefSeq Acc Id: ENST00000369707   ⟹   ENSP00000358721
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,275,162 - 104,304,945 (+)Ensembl
RefSeq Acc Id: ENST00000450629   ⟹   ENSP00000390986
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,268,873 - 104,299,417 (+)Ensembl
RefSeq Acc Id: ENST00000467629
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,285,938 - 104,299,418 (+)Ensembl
RefSeq Acc Id: ENST00000473401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,274,898 - 104,299,414 (+)Ensembl
RefSeq Acc Id: ENST00000477078
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,274,920 - 104,291,644 (+)Ensembl
RefSeq Acc Id: ENST00000498052
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10104,295,275 - 104,299,411 (+)Ensembl
RefSeq Acc Id: NM_001191013   ⟹   NP_001177942
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,304,950 (+)NCBI
GRCh3710106,028,174 - 106,059,176 (+)NCBI
HuRef1099,660,411 - 99,690,935 (+)ENTREZGENE
CHM1_110106,312,517 - 106,343,025 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001191014   ⟹   NP_001177943
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,275,166 - 104,304,950 (+)NCBI
GRCh3710106,028,174 - 106,059,176 (+)NCBI
HuRef1099,660,411 - 99,690,935 (+)ENTREZGENE
CHM1_110106,318,736 - 106,343,025 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001191015   ⟹   NP_001177944
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,275,166 - 104,304,950 (+)NCBI
GRCh3710106,028,174 - 106,059,176 (+)NCBI
HuRef1099,660,411 - 99,690,935 (+)ENTREZGENE
CHM1_110106,318,736 - 106,343,025 (+)NCBI
Sequence:
RefSeq Acc Id: NM_183239   ⟹   NP_899062
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,304,950 (+)NCBI
GRCh3710106,028,174 - 106,059,176 (+)NCBI
Build 3610106,018,621 - 106,049,166 (+)NCBI Archive
HuRef1099,660,411 - 99,690,935 (+)ENTREZGENE
CHM1_110106,312,517 - 106,343,025 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006717624   ⟹   XP_006717687
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,299,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539270   ⟹   XP_011537572
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,267,626 - 104,299,418 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539271   ⟹   XP_011537573
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,290,369 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539272   ⟹   XP_011537574
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,290,261 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539273   ⟹   XP_011537575
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,304,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017015670   ⟹   XP_016871159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,290,369 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017015671   ⟹   XP_016871160
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,290,338 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_899062   ⟸   NM_183239
- Peptide Label: isoform 1
- UniProtKB: Q9H4Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177942   ⟸   NM_001191013
- Peptide Label: isoform 2
- UniProtKB: Q9H4Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177943   ⟸   NM_001191014
- Peptide Label: isoform 3
- UniProtKB: Q9H4Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177944   ⟸   NM_001191015
- Peptide Label: isoform 4
- UniProtKB: Q9H4Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006717687   ⟸   XM_006717624
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011537572   ⟸   XM_011539270
- Peptide Label: isoform X1
- UniProtKB: Q9H4Y5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011537575   ⟸   XM_011539273
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011537574   ⟸   XM_011539272
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011537573   ⟸   XM_011539271
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016871160   ⟸   XM_017015671
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016871159   ⟸   XM_017015670
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000390986   ⟸   ENST00000450629
RefSeq Acc Id: ENSP00000345023   ⟸   ENST00000338595
RefSeq Acc Id: ENSP00000358721   ⟸   ENST00000369707
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:7218615
Promoter ID:EPDNEW_H15052
Type:initiation region
Name:GSTO2_4
Description:glutathione S-transferase omega 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15055  EPDNEW_H15054  EPDNEW_H15056  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,268,858 - 104,268,918EPDNEW
RGD ID:7218619
Promoter ID:EPDNEW_H15054
Type:initiation region
Name:GSTO2_3
Description:glutathione S-transferase omega 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15052  EPDNEW_H15055  EPDNEW_H15056  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,269,184 - 104,269,244EPDNEW
RGD ID:7218617
Promoter ID:EPDNEW_H15055
Type:initiation region
Name:GSTO2_2
Description:glutathione S-transferase omega 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15052  EPDNEW_H15054  EPDNEW_H15056  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,274,905 - 104,274,965EPDNEW
RGD ID:7218621
Promoter ID:EPDNEW_H15056
Type:initiation region
Name:GSTO2_1
Description:glutathione S-transferase omega 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15052  EPDNEW_H15055  EPDNEW_H15054  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810104,275,166 - 104,275,226EPDNEW
RGD ID:6787742
Promoter ID:HG_KWN:11077
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000369708,   NM_183239
Position:
Human AssemblyChrPosition (strand)Source
Build 3610106,017,851 - 106,019,057 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q25.1(chr10:104077161-108350985)x3 copy number gain See cases [RCV000138300] Chr10:104077161..108350985 [GRCh38]
Chr10:105836919..110110743 [GRCh37]
Chr10:105826909..110100733 [NCBI36]
Chr10:10q25.1
uncertain significance
GRCh38/hg38 10q24.32-25.3(chr10:102732173-114085105)x1 copy number loss See cases [RCV000143371] Chr10:102732173..114085105 [GRCh38]
Chr10:104491930..115844864 [GRCh37]
Chr10:104481920..115834854 [NCBI36]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:104633712-135427143)x3 copy number gain See cases [RCV000449386] Chr10:104633712..135427143 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590)x1 copy number loss See cases [RCV000448581] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10q25.1-26.3(chr10:106003533-135427143)x3 copy number gain See cases [RCV000510813] Chr10:106003533..135427143 [GRCh37]
Chr10:10q25.1-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q24.33-26.3(chr10:105613040-135427143)x3 copy number gain not provided [RCV000683290] Chr10:105613040..135427143 [GRCh37]
Chr10:10q24.33-26.3
pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_183239.2(GSTO2):c.121G>A (p.Val41Ile) single nucleotide variant not provided [RCV000962051] Chr10:104275312 [GRCh38]
Chr10:106035070 [GRCh37]
Chr10:10q25.1
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23064 AgrOrtholog
COSMIC GSTO2 COSMIC
Ensembl Genes ENSG00000065621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000345023 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000358721 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000390986 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000338595 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000369707 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000450629 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot
GTEx ENSG00000065621 GTEx
HGNC ID HGNC:23064 ENTREZGENE
Human Proteome Map GSTO2 Human Proteome Map
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_omega UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:119391 UniProtKB/Swiss-Prot
NCBI Gene 119391 ENTREZGENE
OMIM 612314 OMIM
Pfam GST_N_3 UniProtKB/Swiss-Prot
PharmGKB PA133787053 PharmGKB
PRINTS GSTRNSFRASEO UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTO2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A8K771 UniProtKB/Swiss-Prot
  B4DJW6 UniProtKB/Swiss-Prot
  E7ESD6 UniProtKB/Swiss-Prot
  Q49TW5 UniProtKB/Swiss-Prot
  Q5GM70 UniProtKB/Swiss-Prot
  Q5JU15 UniProtKB/Swiss-Prot
  Q86WP3 UniProtKB/Swiss-Prot