Ifi30 (interferon gamma inducible protein 30) - Rat Genome Database
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Gene: Ifi30 (interferon gamma inducible protein 30) Mus musculus
Analyze
Symbol: Ifi30
Name: interferon gamma inducible protein 30
RGD ID: 1321849
MGI Page MGI
Description: Predicted to have oxidoreductase activity, acting on a sulfur group of donors. Involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of fibroblast proliferation; and protein stabilization. Localizes to lysosome. Is expressed in alimentary system; liver; and orbito-sphenoid. Orthologous to human IFI30 (IFI30 lysosomal thiol reductase); PARTICIPATES IN antigen processing and presentation pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: gamma-interferon-inducible lysosomal thiol reductase; gamma-interferon-inducible protein IP-30; GI; GILT; IP; IP30; lysosomal thio reductase IP30; lysosomal thiol reductase IP30
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,215,418 - 71,219,307 (-)NCBIGRCm39mm39
GRCm38870,762,773 - 70,766,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,762,774 - 70,766,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,286,672 - 73,290,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,691,762 - 73,695,638 (-)NCBImm8
Celera873,324,071 - 73,327,964 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (EXP)
2,6-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
fluoranthene  (EXP)
folic acid  (EXP,ISO)
gentamycin  (ISO)
indometacin  (ISO)
L-methionine  (EXP)
lucanthone  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
topiramate  (ISO)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11491538   PMID:11701933   PMID:11812828   PMID:12477932   PMID:12819125   PMID:12904583  
PMID:14610273   PMID:16141072   PMID:16141073   PMID:16982871   PMID:17142755   PMID:18218638   PMID:18606668   PMID:18815593   PMID:19124716   PMID:20485683   PMID:20538950   PMID:20668223  
PMID:21039465   PMID:21267068   PMID:21640818   PMID:21833020   PMID:21873635   PMID:22586035   PMID:23012103   PMID:23326313   PMID:23642353   PMID:25253686   PMID:25875653   PMID:27177843  
PMID:32269095  


Genomics

Comparative Map Data
Ifi30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,215,418 - 71,219,307 (-)NCBIGRCm39mm39
GRCm38870,762,773 - 70,766,663 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,762,774 - 70,766,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,286,672 - 73,290,562 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,691,762 - 73,695,638 (-)NCBImm8
Celera873,324,071 - 73,327,964 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
IFI30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,173,162 - 18,178,117 (+)EnsemblGRCh38hg38GRCh38
GRCh381918,173,813 - 18,178,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,284,590 - 18,288,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,145,579 - 18,149,927 (+)NCBINCBI36hg18NCBI36
Build 341918,145,578 - 18,149,927NCBI
Celera1918,186,321 - 18,190,669 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,848,103 - 17,852,447 (+)NCBIHuRef
CHM1_11918,284,148 - 18,288,492 (+)NCBICHM1_1
Ifi30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01620,426,566 - 20,430,772 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,426,566 - 20,430,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,283,634 - 20,287,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,181,236 - 19,185,438 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,181,233 - 19,185,350 (+)NCBI
Celera1618,867,868 - 18,872,074 (+)NCBICelera
Cytogenetic Map16p14NCBI
Ifi30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,229,257 - 3,231,825 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,229,024 - 3,230,955 (-)NCBIChiLan1.0ChiLan1.0
IFI30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,629,663 - 18,634,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,629,663 - 18,635,046 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,652,935 - 17,657,239 (+)NCBIMhudiblu_PPA_v0panPan3
IFI30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2044,819,893 - 44,823,342 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,819,862 - 44,823,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ifi30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,003,366 - 3,007,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFI30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,629,765 - 59,634,221 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,629,762 - 59,633,714 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,214,057 - 59,218,009 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IFI30
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl616,644,392 - 16,649,751 (+)Ensembl
ChlSab1.1616,644,361 - 16,649,599 (+)NCBI
Ifi30
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,525,290 - 1,528,202 (+)NCBI

Position Markers
Y13569  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,768,215 - 70,768,361UniSTSGRCm38
MGSCv37873,292,114 - 73,292,260UniSTSGRCm37
Celera873,329,516 - 73,329,662UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8743.32UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:123
Interacting mature miRNAs:127
Transcripts:ENSMUST00000034299
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034299
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,762,774 - 70,766,663 (-)Ensembl
RefSeq Acc Id: ENSMUST00000222087
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,762,774 - 70,766,663 (-)Ensembl
RefSeq Acc Id: NM_023065   ⟹   NP_075552
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,215,418 - 71,219,307 (-)NCBI
GRCm38870,762,773 - 70,766,663 (-)ENTREZGENE
MGSCv37873,286,672 - 73,290,562 (-)RGD
Celera873,324,071 - 73,327,964 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075552   ⟸   NM_023065
- Peptide Label: precursor
- UniProtKB: Q9ESY9 (UniProtKB/Swiss-Prot)
- Sequence:

Promoters
RGD ID:8667345
Promoter ID:EPDNEW_M11704
Type:multiple initiation site
Name:Ifi30_1
Description:Mus musculus interferon gamma inducible protein 30 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,766,663 - 70,766,723EPDNEW
RGD ID:15093462
Promoter ID:EPDNEWNC_M1365
Type:single initiation site
Name:Ifi30_1
Description:interferon gamma inducible protein 30 [Source:MGISymbol;Acc:MGI:2137648]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,766,663 - 70,766,723EPDNEWNC
RGD ID:6848305
Promoter ID:MM_ACW:47859
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:IFI30.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,288,551 - 73,289,051 (-)MPROMDB
RGD ID:6843311
Promoter ID:MM_KWN:54739
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_023065,   NM_023065_IFI30
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36873,290,461 - 73,291,397 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2137648 AgrOrtholog
Ensembl Genes ENSMUSG00000031838 Ensembl, ENTREZGENE
  ENSMUSG00000110777 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000149915 UniProtKB/Swiss-Prot
  ENSMUSP00000155679 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000213938 UniProtKB/Swiss-Prot
  ENSMUST00000222087 ENTREZGENE
  ENSMUST00000229632 UniProtKB/Swiss-Prot
InterPro Interferon-induced_GILT UniProtKB/Swiss-Prot
KEGG Report mmu:65972 UniProtKB/Swiss-Prot
MGD MGI:2137648 ENTREZGENE
NCBI Gene 65972 ENTREZGENE
PANTHER PTHR13234 UniProtKB/Swiss-Prot
Pfam GILT UniProtKB/Swiss-Prot
PhenoGen Ifi30 PhenoGen
UniGene Mm.30241 ENTREZGENE
UniProt GILT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3X911 UniProtKB/Swiss-Prot
  Q3U0F9 UniProtKB/Swiss-Prot
  Q9EP56 UniProtKB/Swiss-Prot