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Gene: Flt3 (FMS-like tyrosine kinase 3) Mus musculus
Symbol: Flt3
Name: FMS-like tyrosine kinase 3
Description: Exhibits several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cytokine production; and positive regulation of cytokine secretion. Localizes to the external side of plasma membrane. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; precursor lymphoblastic lymphoma/leukemia; and prostate cancer. Is expressed in several structures, including central nervous system; dorsal aorta; immune system; reproductive system; and retina. Orthologous to human FLT3 (fms related tyrosine kinase 3); PARTICIPATES IN acute myeloid leukemia pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B230315G04; CD135; fetal liver kinase 2; FL cytokine receptor; Flk-2; Flk2; Flt-3; Ly72; MGC124377; MGC124378; receptor-type tyrosine-protein kinase FLT3; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; wmfl
Homo sapiens (human) : FLT3 (fms related receptor tyrosine kinase 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt3 (Fms related receptor tyrosine kinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt3 (fms related receptor tyrosine kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT3 (fms related receptor tyrosine kinase 3)
Canis lupus familiaris (dog) : FLT3 (fms related receptor tyrosine kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt3 (fms related receptor tyrosine kinase 3)
Sus scrofa (pig) : FLT3 (fms related receptor tyrosine kinase 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5147,330,741 - 147,400,489 (-)Ensembl
GRCm385147,330,741 - 147,400,489 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375148,142,317 - 148,212,065 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,641,095 - 147,710,644 (-)NCBImm8
Celera5145,322,183 - 145,394,029 (-)NCBICelera
Cytogenetic Map5 G3NCBI
cM Map586.88NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Flt3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321715
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.