Sh3bp2 (SH3-domain binding protein 2) - Rat Genome Database

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Gene: Sh3bp2 (SH3-domain binding protein 2) Mus musculus
Analyze
Symbol: Sh3bp2
Name: SH3-domain binding protein 2
RGD ID: 1321584
MGI Page MGI
Description: Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Is expressed in brain and spinal cord. Used to study cherubism. Human ortholog(s) of this gene implicated in cherubism. Orthologous to human SH3BP2 (SH3 domain binding protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3BP; 3BP-2; 3BP2; SH3 domain-binding protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,683,128 - 34,720,983 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,683,182 - 34,720,985 (+)EnsemblGRCm39 Ensembl
GRCm38534,525,784 - 34,563,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,525,838 - 34,563,641 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,868,433 - 34,906,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,842,703 - 34,880,483 (+)NCBIMGSCv36mm8
Celera531,996,748 - 32,034,601 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
azoxystrobin  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
fenthion  (EXP)
flutamide  (ISO)
FR900359  (ISO)
gentamycin  (ISO)
glucose  (EXP)
glyphosate  (EXP,ISO)
hydroquinone  (ISO)
imidacloprid  (ISO)
inulin  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
thiabendazole  (ISO)
titanium dioxide  (EXP)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell number  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal enzyme/coenzyme level  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal interleukin-6 secretion  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal marginal zone B cell physiology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal spleen marginal zone morphology  (IAGP)
alveolar process atrophy  (IAGP)
blepharitis  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone trabecula number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased pro-B cell number  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased transitional stage B cell number  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
dermatitis  (IAGP)
enlarged lymph nodes  (IAGP)
head/neck swellings  (IAGP)
impaired macrophage phagocytosis  (IAGP)
increased B cell apoptosis  (IAGP)
increased bone mass  (IAGP)
increased bone mineral density  (IAGP)
increased bone trabecula number  (IAGP)
increased circulating aspartate transaminase level  (IEA)
increased circulating interleukin-12 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased compact bone thickness  (IAGP)
increased inflammatory response  (IAGP)
increased marginal zone B cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased pre-B cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased trabecular bone thickness  (IAGP)
increased trabecular bone volume  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
joint inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
lymph node inflammation  (IAGP)
myositis  (IAGP)
osteomyelitis  (IAGP)
premature death  (IAGP)
short tibia  (IEA)
spinal cord inflammation  (IAGP)
stomach inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism. Ueki Y, etal., Nat Genet. 2001 Jun;28(2):125-6.
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8438166   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12709437   PMID:16141072   PMID:16141073   PMID:16809760   PMID:17218256   PMID:17283041  
PMID:18440306   PMID:18799693   PMID:18846253   PMID:19587764   PMID:20117257   PMID:20691350   PMID:21267068   PMID:21448930   PMID:21677750   PMID:21738685   PMID:21765218   PMID:21794028  
PMID:21873635   PMID:22153076   PMID:22153077   PMID:22815290   PMID:22896635   PMID:24916406   PMID:24978678   PMID:25144740   PMID:25220465   PMID:25445458   PMID:25705883   PMID:25859222  
PMID:27626380   PMID:27797343   PMID:28287403   PMID:28914985   PMID:29530719   PMID:30067970   PMID:31052273   PMID:31613396   PMID:32554809   PMID:33920631   PMID:35129602   PMID:35362478  
PMID:38127456  


Genomics

Comparative Map Data
Sh3bp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,683,128 - 34,720,983 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,683,182 - 34,720,985 (+)EnsemblGRCm39 Ensembl
GRCm38534,525,784 - 34,563,639 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,525,838 - 34,563,641 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,868,433 - 34,906,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,842,703 - 34,880,483 (+)NCBIMGSCv36mm8
Celera531,996,748 - 32,034,601 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.89NCBI
SH3BP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,793,085 - 2,841,096 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,793,071 - 2,841,098 (+)EnsemblGRCh38hg38GRCh38
GRCh3742,794,812 - 2,842,823 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,790,339 - 2,810,712 (+)NCBINCBI36Build 36hg18NCBI36
Build 3442,857,545 - 2,877,920NCBI
Celera42,706,072 - 2,754,024 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,733,534 - 2,781,278 (+)NCBIHuRef
CHM1_142,792,693 - 2,840,796 (+)NCBICHM1_1
T2T-CHM13v2.042,791,852 - 2,839,552 (+)NCBIT2T-CHM13v2.0
Sh3bp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,400,685 - 80,437,887 (-)NCBIGRCr8
mRatBN7.21476,176,097 - 76,213,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,176,101 - 76,213,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,628,679 - 80,665,764 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,869,326 - 81,906,411 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,314,567 - 78,351,655 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,435,445 - 81,473,013 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,435,449 - 81,472,952 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,122,929 - 82,160,479 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,818,728 - 81,855,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,822,156 - 81,855,721 (-)NCBI
Celera1475,100,620 - 75,137,766 (-)NCBICelera
Cytogenetic Map14q21NCBI
Sh3bp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,712,793 - 1,730,002 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,700,889 - 1,730,002 (+)NCBIChiLan1.0ChiLan1.0
SH3BP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,129,178 - 3,172,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,065,091 - 3,108,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,936,051 - 2,982,062 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,838,521 - 2,882,265 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,857,249 - 2,882,263 (+)Ensemblpanpan1.1panPan2
SH3BP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,454,945 - 61,488,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,358,162 - 61,474,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,038,628 - 64,072,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,930,906 - 61,964,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,930,906 - 61,964,886 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,422,146 - 61,456,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,627,161 - 61,661,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,986,786 - 62,020,764 (-)NCBIUU_Cfam_GSD_1.0
Sh3bp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,072,693 - 67,106,061 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,773,016 - 20,807,722 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,774,386 - 20,794,958 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3BP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,583,193 - 1,619,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,583,169 - 1,619,038 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,164,569 - 1,201,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH3BP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,919,717 - 45,961,355 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,920,171 - 45,942,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660512,275,298 - 2,323,644 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3bp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,941,813 - 24,957,004 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,942,542 - 24,968,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh3bp2
999 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2036
Count of miRNA genes:511
Interacting mature miRNAs:639
Transcripts:ENSMUST00000067638, ENSMUST00000101316, ENSMUST00000118545, ENSMUST00000125817, ENSMUST00000138912, ENSMUST00000153750, ENSMUST00000179943
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse

Markers in Region
D5Jcs82  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38534,550,205 - 34,550,370UniSTSGRCm38
MGSCv37534,892,854 - 34,893,019UniSTSGRCm37
Celera532,021,169 - 32,021,332UniSTS
Cytogenetic Map5B2UniSTS
cM Map5 UniSTS
L14543  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38534,563,132 - 34,563,277UniSTSGRCm38
MGSCv37534,905,781 - 34,905,926UniSTSGRCm37
Celera532,034,094 - 32,034,239UniSTS
Cytogenetic Map5B2UniSTS
Whitehead/MRC_RH5451.65UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001145859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000067638   ⟹   ENSMUSP00000070890
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,683,190 - 34,720,985 (+)Ensembl
GRCm38.p6 Ensembl534,525,846 - 34,563,641 (+)Ensembl
RefSeq Acc Id: ENSMUST00000101316   ⟹   ENSMUSP00000098874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,700,709 - 34,720,969 (+)Ensembl
GRCm38.p6 Ensembl534,543,365 - 34,563,625 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118545   ⟹   ENSMUSP00000112554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,706,920 - 34,720,969 (+)Ensembl
GRCm38.p6 Ensembl534,549,576 - 34,563,625 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125817   ⟹   ENSMUSP00000123177
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,683,182 - 34,709,044 (+)Ensembl
GRCm38.p6 Ensembl534,525,838 - 34,551,700 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138912   ⟹   ENSMUSP00000114416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,700,709 - 34,710,090 (+)Ensembl
GRCm38.p6 Ensembl534,543,365 - 34,552,746 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153750
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,700,709 - 34,715,065 (+)Ensembl
GRCm38.p6 Ensembl534,543,365 - 34,557,721 (+)Ensembl
RefSeq Acc Id: ENSMUST00000179943   ⟹   ENSMUSP00000136671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,707,032 - 34,720,982 (+)Ensembl
GRCm38.p6 Ensembl534,549,688 - 34,563,638 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl534,708,889 - 34,710,136 (+)Ensembl
GRCm38.p6 Ensembl534,551,545 - 34,552,792 (+)Ensembl
RefSeq Acc Id: NM_001145858   ⟹   NP_001139330
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,700,709 - 34,720,983 (+)NCBI
GRCm38534,543,365 - 34,563,639 (+)NCBI
MGSCv37534,868,433 - 34,906,288 (+)RGD
Celera531,996,748 - 32,034,601 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001145859   ⟹   NP_001139331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,706,920 - 34,720,983 (+)NCBI
GRCm38534,549,576 - 34,563,639 (+)NCBI
MGSCv37534,868,433 - 34,906,288 (+)RGD
Celera531,996,748 - 32,034,601 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011893   ⟹   NP_036023
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,683,128 - 34,720,983 (+)NCBI
GRCm38534,525,784 - 34,563,639 (+)ENTREZGENE
MGSCv37534,868,433 - 34,906,288 (+)RGD
Celera531,996,748 - 32,034,601 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503954   ⟹   XP_006504017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,694,231 - 34,720,970 (+)NCBI
GRCm38534,536,941 - 34,563,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503955   ⟹   XP_006504018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39534,701,576 - 34,720,970 (+)NCBI
GRCm38534,544,232 - 34,563,626 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036023   ⟸   NM_011893
- Peptide Label: isoform a
- UniProtKB: Q5U3L0 (UniProtKB/TrEMBL),   Q8C220 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139330   ⟸   NM_001145858
- Peptide Label: isoform c
- UniProtKB: Q3UD40 (UniProtKB/TrEMBL),   Q3U1H0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139331   ⟸   NM_001145859
- Peptide Label: isoform b
- UniProtKB: E9QJU7 (UniProtKB/TrEMBL),   Q8C220 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006504017   ⟸   XM_006503954
- Peptide Label: isoform X1
- UniProtKB: Q5U3L0 (UniProtKB/TrEMBL),   Q8C220 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006504018   ⟸   XM_006503955
- Peptide Label: isoform X1
- UniProtKB: Q5U3L0 (UniProtKB/TrEMBL),   Q8C220 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000123177   ⟸   ENSMUST00000125817
RefSeq Acc Id: ENSMUSP00000114416   ⟸   ENSMUST00000138912
RefSeq Acc Id: ENSMUSP00000112554   ⟸   ENSMUST00000118545
RefSeq Acc Id: ENSMUSP00000070890   ⟸   ENSMUST00000067638
RefSeq Acc Id: ENSMUSP00000136671   ⟸   ENSMUST00000179943
RefSeq Acc Id: ENSMUSP00000098874   ⟸   ENSMUST00000101316
Protein Domains
PH   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06649-F1-model_v2 AlphaFold Q06649 1-559 view protein structure

Promoters
RGD ID:6886468
Promoter ID:EPDNEW_M6685
Type:initiation region
Name:Sh3bp2_3
Description:Mus musculus SH3-domain binding protein 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6686  EPDNEW_M6687  EPDNEW_M6688  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38534,525,837 - 34,525,897EPDNEW
RGD ID:6886470
Promoter ID:EPDNEW_M6686
Type:single initiation site
Name:Sh3bp2_1
Description:Mus musculus SH3-domain binding protein 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6685  EPDNEW_M6687  EPDNEW_M6688  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38534,530,651 - 34,530,711EPDNEW
RGD ID:6886472
Promoter ID:EPDNEW_M6687
Type:initiation region
Name:Sh3bp2_2
Description:Mus musculus SH3-domain binding protein 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6685  EPDNEW_M6686  EPDNEW_M6688  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38534,543,421 - 34,543,481EPDNEW
RGD ID:6886474
Promoter ID:EPDNEW_M6688
Type:initiation region
Name:Sh3bp2_4
Description:Mus musculus SH3-domain binding protein 2 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6685  EPDNEW_M6686  EPDNEW_M6687  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38534,549,601 - 34,549,661EPDNEW
RGD ID:6838339
Promoter ID:MM_KWN:41968
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:NM_011893,   OTTMUST00000066135
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36534,868,384 - 34,868,884 (+)MPROMDB
RGD ID:6838340
Promoter ID:MM_KWN:41969
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:NM_001145858,   OTTMUST00000066136,   OTTMUST00000066674
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36534,885,056 - 34,886,057 (+)MPROMDB
RGD ID:6838333
Promoter ID:MM_KWN:41970
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_001145859
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36534,891,306 - 34,892,647 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346349 AgrOrtholog
Ensembl Genes ENSMUSG00000054520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067638 ENTREZGENE
  ENSMUST00000067638.14 UniProtKB/TrEMBL
  ENSMUST00000101316 ENTREZGENE
  ENSMUST00000101316.10 UniProtKB/TrEMBL
  ENSMUST00000118545 ENTREZGENE
  ENSMUST00000118545.8 UniProtKB/TrEMBL
  ENSMUST00000125817.8 UniProtKB/TrEMBL
  ENSMUST00000138912.8 UniProtKB/TrEMBL
  ENSMUST00000179943 ENTREZGENE
  ENSMUST00000179943.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3BP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3BP2_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:24055 UniProtKB/TrEMBL
MGD MGI:1346349 ENTREZGENE
NCBI Gene 24055 ENTREZGENE
PANTHER PTHR15126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 DOMAIN-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh3bp2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 3BP2_MOUSE UniProtKB/Swiss-Prot
  D3Z107_MOUSE UniProtKB/TrEMBL
  D6RDU0_MOUSE UniProtKB/TrEMBL
  E9QJU7 ENTREZGENE, UniProtKB/TrEMBL
  Q06649 ENTREZGENE
  Q3U0G0_MOUSE UniProtKB/TrEMBL
  Q3U1H0 ENTREZGENE, UniProtKB/TrEMBL
  Q3UD40 ENTREZGENE, UniProtKB/TrEMBL
  Q5U3L0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C220 ENTREZGENE, UniProtKB/TrEMBL
  Q91Z52_MOUSE UniProtKB/TrEMBL