Tmem17 (transmembrane protein 17) - Rat Genome Database

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Gene: Tmem17 (transmembrane protein 17) Mus musculus
Analyze
Symbol: Tmem17
Name: transmembrane protein 17
RGD ID: 1321546
MGI Page MGI
Description: Involved in cilium assembly. Acts upstream of or within smoothened signaling pathway. Located in ciliary membrane and ciliary transition zone. Part of MKS complex. Orthologous to human TMEM17 (transmembrane protein 17).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AI503894; AW049890; MGC40971; RP23-401L13.4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391122,462,283 - 22,469,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1122,462,088 - 22,469,234 (+)EnsemblGRCm39 Ensembl
GRCm381122,512,283 - 22,519,231 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1122,512,088 - 22,519,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,412,286 - 22,419,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,412,286 - 22,419,234 (+)NCBIMGSCv36mm8
Celera1124,649,073 - 24,656,059 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10922068   PMID:12477932   PMID:14610273   PMID:15489334   PMID:21873635   PMID:22179047  


Genomics

Comparative Map Data
Tmem17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391122,462,283 - 22,469,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1122,462,088 - 22,469,234 (+)EnsemblGRCm39 Ensembl
GRCm381122,512,283 - 22,519,231 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1122,512,088 - 22,519,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv371122,412,286 - 22,419,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361122,412,286 - 22,419,234 (+)NCBIMGSCv36mm8
Celera1124,649,073 - 24,656,059 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.17NCBI
TMEM17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38262,453,531 - 62,506,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl262,500,218 - 62,511,894 (-)EnsemblGRCh38hg38GRCh38
GRCh37262,727,353 - 62,733,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36262,581,252 - 62,586,980 (-)NCBINCBI36Build 36hg18NCBI36
Build 34262,639,412 - 62,645,127NCBI
Celera262,572,191 - 62,578,440 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef262,465,324 - 62,471,573 (-)NCBIHuRef
CHM1_1262,657,923 - 62,664,172 (-)NCBICHM1_1
T2T-CHM13v2.0262,459,855 - 62,512,518 (-)NCBIT2T-CHM13v2.0
Tmem17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814100,684,655 - 100,725,471 (+)NCBIGRCr8
mRatBN7.21496,483,648 - 96,524,238 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1496,518,793 - 96,524,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14100,863,078 - 100,869,002 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,105,343 - 102,111,268 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01498,576,957 - 98,582,881 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014107,268,235 - 107,308,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14107,268,128 - 107,308,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014107,331,758 - 107,371,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,162,310 - 103,167,728 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114103,181,520 - 103,186,939 (+)NCBI
Celera1495,508,270 - 95,513,688 (+)NCBICelera
Cytogenetic Map14q22NCBI
Tmem17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542421,627,151 - 21,637,041 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542421,627,889 - 21,634,798 (+)NCBIChiLan1.0ChiLan1.0
TMEM17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21263,877,577 - 63,886,644 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A63,881,521 - 63,890,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A62,580,872 - 62,587,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A63,710,004 - 63,716,422 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A63,710,004 - 63,716,422 (-)Ensemblpanpan1.1panPan2
TMEM17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11062,355,849 - 62,361,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1062,356,277 - 62,361,397 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1062,243,628 - 62,249,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01063,363,234 - 63,368,846 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1063,363,662 - 63,368,797 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11063,046,203 - 63,051,806 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01063,349,705 - 63,355,323 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01063,646,177 - 63,651,789 (-)NCBIUU_Cfam_GSD_1.0
Tmem17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629220,844,325 - 20,850,142 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364917,719,658 - 7,727,107 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364917,721,150 - 7,726,983 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl379,415,717 - 79,422,393 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1379,415,767 - 79,422,397 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMEM17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11444,462,402 - 44,468,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1444,462,158 - 44,468,975 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604567,365,751 - 67,371,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476210,969,765 - 10,976,870 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476210,970,048 - 10,975,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem17
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:146
Interacting mature miRNAs:151
Transcripts:ENSMUST00000059319
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse

Markers in Region
AW049890  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,518,865 - 22,518,998UniSTSGRCm38
MGSCv371122,418,868 - 22,419,001UniSTSGRCm37
Celera1124,655,693 - 24,655,826UniSTS
Cytogenetic Map11A3.2UniSTS
AI503894  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,518,981 - 22,519,157UniSTSGRCm38
MGSCv371122,418,984 - 22,419,160UniSTSGRCm37
Celera1124,655,809 - 24,655,985UniSTS
Cytogenetic Map11A3.2UniSTS
Whitehead/MRC_RH11394.16UniSTS
UniSTS:236531  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381122,518,939 - 22,519,151UniSTSGRCm38
MGSCv371122,418,942 - 22,419,154UniSTSGRCm37
Celera1124,655,767 - 24,655,979UniSTS
Cytogenetic Map11A3.2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000059319   ⟹   ENSMUSP00000051414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1122,462,088 - 22,469,234 (+)Ensembl
GRCm38.p6 Ensembl1122,512,088 - 22,519,234 (+)Ensembl
RefSeq Acc Id: NM_153596   ⟹   NP_705824
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391122,462,283 - 22,469,231 (+)NCBI
GRCm381122,512,283 - 22,519,231 (+)NCBI
MGSCv371122,412,286 - 22,419,234 (+)RGD
Celera1124,649,073 - 24,656,059 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_705824 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH30386 (Get FASTA)   NCBI Sequence Viewer  
  EDL07863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000051414
  ENSMUSP00000051414.8
GenBank Protein Q8K0U3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_705824   ⟸   NM_153596
- UniProtKB: Q8K0U3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000051414   ⟸   ENSMUST00000059319

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K0U3-F1-model_v2 AlphaFold Q8K0U3 1-198 view protein structure

Promoters
RGD ID:6822340
Promoter ID:MM_KWN:6634
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000011728
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361122,412,331 - 22,412,831 (+)MPROMDB
RGD ID:8674082
Promoter ID:EPDNEW_M15072
Type:multiple initiation site
Name:Tmem17_1
Description:Mus musculus transmembrane protein 17 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381122,512,278 - 22,512,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2144205 AgrOrtholog
Ensembl Genes ENSMUSG00000049904 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059319 ENTREZGENE
  ENSMUST00000059319.8 UniProtKB/Swiss-Prot
InterPro Uncharacterised_TM-17 UniProtKB/Swiss-Prot
KEGG Report mmu:103765 UniProtKB/Swiss-Prot
MGD MGI:2144205 ENTREZGENE
NCBI Gene 103765 ENTREZGENE
PANTHER PTHR13531 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 17 UniProtKB/Swiss-Prot
Pfam Transmemb_17 UniProtKB/Swiss-Prot
PhenoGen Tmem17 PhenoGen
UniProt Q8K0U3 ENTREZGENE, UniProtKB/Swiss-Prot