WTAP (WT1 associated protein) - Rat Genome Database

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Gene: WTAP (WT1 associated protein) Homo sapiens
Analyze
Symbol: WTAP
Name: WT1 associated protein
RGD ID: 1321461
HGNC Page HGNC:16846
Description: Enables identical protein binding activity. Involved in mRNA methylation and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear membrane and nuclear speck. Part of RNA N6-methyladenosine methyltransferase complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686F20131; female-lethal(2)D homolog; hFL(2)D; KIAA0105; MGC3925; Mum2; PNAS-132; pre-mRNA-splicing regulator WTAP; putative pre-mRNA splicing regulator female-lethal(2D); wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC646517   WTAPP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,726,693 - 159,756,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,725,585 - 159,756,319 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,148,149 - 160,177,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,068,142 - 160,097,341 (+)NCBINCBI36hg18NCBI36
Celera6160,794,229 - 160,823,430 (+)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,617,339 - 157,646,781 (+)NCBIHuRef
CHM1_16160,410,378 - 160,439,680 (+)NCBICHM1_1
T2T-CHM13v2.06160,972,746 - 161,001,943 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISS)
nuclear membrane  (IDA)
nuclear speck  (IDA,IEA)
nucleoplasm  (IDA,IEA,TAS)
nucleus  (IBA,IC,IDA,IEA)
RNA N6-methyladenosine methyltransferase complex  (IDA,IPI)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7788527   PMID:10942595   PMID:11001926   PMID:12444081   PMID:12477932   PMID:12522145   PMID:14675924   PMID:15009096   PMID:15146197   PMID:15161933   PMID:15302935   PMID:15489334  
PMID:16189514   PMID:16344560   PMID:16912181   PMID:17088532   PMID:17095724   PMID:17207965   PMID:18029348   PMID:18505803   PMID:19084217   PMID:19322201   PMID:19531213   PMID:19605357  
PMID:19969384   PMID:21516116   PMID:21873635   PMID:21988832   PMID:22678362   PMID:22939629   PMID:22957919   PMID:23354623   PMID:24100041   PMID:24316715   PMID:24407421   PMID:24413322  
PMID:24981863   PMID:25281560   PMID:25416956   PMID:25693804   PMID:26071132   PMID:26186194   PMID:26344197   PMID:26458103   PMID:26496610   PMID:26949739   PMID:27370540   PMID:27609421  
PMID:27684187   PMID:28077445   PMID:28514442   PMID:29117863   PMID:29128334   PMID:29229926   PMID:29298432   PMID:29348140   PMID:29395067   PMID:29482572   PMID:29489750   PMID:29506078  
PMID:29507755   PMID:29509190   PMID:29615496   PMID:29656893   PMID:29802200   PMID:30143009   PMID:30196744   PMID:30344098   PMID:30804394   PMID:30804502   PMID:30890647   PMID:31091453  
PMID:31405213   PMID:31438961   PMID:32176425   PMID:32281240   PMID:32296183   PMID:32382056   PMID:32504654   PMID:32787827   PMID:32814762   PMID:32866786   PMID:32880751   PMID:32951457  
PMID:32994395   PMID:32998774   PMID:33205540   PMID:33217317   PMID:33306668   PMID:33367479   PMID:33378974   PMID:33559954   PMID:33625109   PMID:33819187   PMID:33961781   PMID:34079125  
PMID:34133714   PMID:34312368   PMID:34329695   PMID:34373451   PMID:34627420   PMID:34634995   PMID:34711951   PMID:34828353   PMID:34831298   PMID:34866525   PMID:34999731   PMID:35013218  
PMID:35032548   PMID:35143566   PMID:35271311   PMID:35304463   PMID:35650605   PMID:35733918  


Genomics

Comparative Map Data
WTAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,726,693 - 159,756,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6159,725,585 - 159,756,319 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,148,149 - 160,177,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,068,142 - 160,097,341 (+)NCBINCBI36hg18NCBI36
Celera6160,794,229 - 160,823,430 (+)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6157,617,339 - 157,646,781 (+)NCBIHuRef
CHM1_16160,410,378 - 160,439,680 (+)NCBICHM1_1
T2T-CHM13v2.06160,972,746 - 161,001,943 (+)NCBI
Wtap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,185,686 - 13,211,430 (-)NCBIGRCm39mm39
GRCm39 Ensembl1713,185,683 - 13,213,056 (-)Ensembl
GRCm381712,966,799 - 12,992,543 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,966,796 - 12,994,169 (-)EnsemblGRCm38mm10GRCm38
MGSCv371713,159,665 - 13,185,405 (-)NCBIGRCm37mm9NCBIm37
MGSCv361712,815,617 - 12,835,478 (-)NCBImm8
Celera1712,998,333 - 13,025,542 (-)NCBICelera
Cytogenetic Map17A1NCBI
Wtap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2147,665,965 - 47,691,067 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl147,665,965 - 47,691,065 (+)Ensembl
Rnor_6.0147,942,500 - 47,967,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,942,500 - 47,967,631 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,781,701 - 51,806,726 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,891,437 - 41,917,254 (+)NCBIRGSC3.4rn4RGSC3.4
Celera143,351,111 - 43,376,211 (+)NCBICelera
Cytogenetic Map1q11NCBI
Wtap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543921,146,206 - 21,182,486 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543921,149,970 - 21,174,479 (-)NCBIChiLan1.0ChiLan1.0
WTAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16162,620,947 - 162,650,683 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,621,842 - 162,650,683 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06157,609,779 - 157,639,122 (+)NCBIMhudiblu_PPA_v0panPan3
WTAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,976,523 - 49,004,536 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,976,499 - 49,003,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,818,344 - 49,846,503 (+)NCBI
ROS_Cfam_1.0149,160,699 - 49,189,019 (+)NCBI
ROS_Cfam_1.0 Ensembl149,160,693 - 49,189,019 (+)Ensembl
UMICH_Zoey_3.1149,043,176 - 49,071,381 (+)NCBI
UNSW_CanFamBas_1.0148,914,192 - 48,942,472 (+)NCBI
UU_Cfam_GSD_1.0149,529,308 - 49,557,423 (+)NCBI
UU_Cfam_GSD_1.0149,480,343 - 49,508,532 (+)NCBI
LOC101963588
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,966,743 - 143,997,439 (+)NCBI
SpeTri2.0NW_00493648911,222,513 - 11,249,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WTAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,622,547 - 7,651,961 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,622,544 - 7,651,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,419,861 - 9,447,657 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103240819
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,328,228 - 87,357,868 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604059,727,150 - 59,756,923 (+)NCBIVero_WHO_p1.0
Wtap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,205,543 - 3,235,979 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248553,205,543 - 3,236,134 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH45346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,174,310 - 160,174,509UniSTSGRCh37
Build 366160,094,300 - 160,094,499RGDNCBI36
Celera6160,820,389 - 160,820,588RGD
Cytogenetic Map6q25-q27UniSTS
HuRef6157,643,740 - 157,643,939UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
NCBI RH Map61631.6UniSTS
RH45351  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,152,794 - 160,152,917UniSTSGRCh37
Build 366160,072,784 - 160,072,907RGDNCBI36
Celera6160,798,871 - 160,798,994RGD
Cytogenetic Map6q25-q27UniSTS
HuRef6157,622,096 - 157,622,219UniSTS
GeneMap99-GB4 RH Map6619.81UniSTS
NCBI RH Map61624.4UniSTS
RH25332  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37651,274,655 - 51,275,048UniSTSGRCh37
GRCh376160,169,236 - 160,169,618UniSTSGRCh37
Build 366160,089,226 - 160,089,608RGDNCBI36
Celera652,934,393 - 52,934,786UniSTS
Celera6160,815,313 - 160,815,695RGD
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map6q25-q27UniSTS
HuRef651,109,651 - 51,110,044UniSTS
HuRef6157,638,666 - 157,639,048UniSTS
RH40826  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37651,273,986 - 51,274,212UniSTSGRCh37
GRCh376160,170,064 - 160,170,290UniSTSGRCh37
Build 366160,090,054 - 160,090,280RGDNCBI36
Celera652,933,724 - 52,933,950UniSTS
Celera6160,816,141 - 160,816,367RGD
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map6q25-q27UniSTS
HuRef651,108,982 - 51,109,208UniSTS
HuRef6157,639,494 - 157,639,720UniSTS
RH45141  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,176,837 - 160,177,065UniSTSGRCh37
Build 366160,096,827 - 160,097,055RGDNCBI36
Celera6160,822,916 - 160,823,144RGD
Cytogenetic Map6q25-q27UniSTS
HuRef6157,646,267 - 157,646,495UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
NCBI RH Map61631.6UniSTS
SHGC-56803  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,146,983 - 160,147,104UniSTSGRCh37
Build 366160,066,973 - 160,067,094RGDNCBI36
Celera6160,793,060 - 160,793,181RGD
Cytogenetic Map6q25-q27UniSTS
HuRef6157,616,292 - 157,616,413UniSTS
TNG Radiation Hybrid Map680094.0UniSTS
D6S1433  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,170,329 - 160,170,430UniSTSGRCh37
GRCh37651,273,848 - 51,273,949UniSTSGRCh37
Build 366160,090,319 - 160,090,420RGDNCBI36
Celera6160,816,406 - 160,816,507RGD
Celera652,933,586 - 52,933,687UniSTS
Cytogenetic Map6q25-q27UniSTS
Cytogenetic Map6p12.3UniSTS
HuRef651,108,844 - 51,108,945UniSTS
HuRef6157,639,759 - 157,639,860UniSTS
GeneMap99-GB4 RH Map6622.06UniSTS
Whitehead-RH Map6831.1UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61637.4UniSTS
SHGC-56705  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376160,147,506 - 160,147,601UniSTSGRCh37
Build 366160,067,496 - 160,067,591RGDNCBI36
Celera6160,793,583 - 160,793,678RGD
Cytogenetic Map6q25-q27UniSTS
HuRef6157,616,815 - 157,616,910UniSTS
TNG Radiation Hybrid Map680088.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:788
Count of miRNA genes:579
Interacting mature miRNAs:630
Transcripts:ENST00000337387, ENST00000358372, ENST00000462110, ENST00000494513
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2432 2691 1653 554 1861 396 4343 2007 3254 399 1447 1605 171 1204 2778 4
Low 7 300 73 70 90 69 14 190 480 20 11 8 4 1 10 2 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_152858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017011516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA706250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF374416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL135914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL583911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE906617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG702882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ778248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ948913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX387163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN284477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR627456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA138013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA561768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000337387   ⟹   ENSP00000336911
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,727,588 - 159,749,415 (+)Ensembl
RefSeq Acc Id: ENST00000358372   ⟹   ENSP00000351141
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,725,585 - 159,756,319 (+)Ensembl
RefSeq Acc Id: ENST00000462110
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,741,593 - 159,743,694 (+)Ensembl
RefSeq Acc Id: ENST00000494513
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,727,530 - 159,736,718 (+)Ensembl
RefSeq Acc Id: ENST00000614346   ⟹   ENSP00000484404
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,726,998 - 159,749,416 (+)Ensembl
RefSeq Acc Id: ENST00000621533   ⟹   ENSP00000479438
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,727,506 - 159,756,319 (+)Ensembl
RefSeq Acc Id: ENST00000631126   ⟹   ENSP00000487338
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,727,566 - 159,749,421 (+)Ensembl
RefSeq Acc Id: ENST00000650096   ⟹   ENSP00000497840
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl6159,726,996 - 159,755,713 (+)Ensembl
RefSeq Acc Id: NM_001270531   ⟹   NP_001257460
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,506 - 159,756,319 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,880 - 160,439,680 (+)NCBI
T2T-CHM13v2.06160,973,156 - 161,001,943 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270532   ⟹   NP_001257461
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,117 - 159,749,419 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,378 - 160,432,774 (+)NCBI
T2T-CHM13v2.06160,972,746 - 160,995,042 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270533   ⟹   NP_001257462
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,506 - 159,749,419 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,880 - 160,432,774 (+)NCBI
T2T-CHM13v2.06160,973,156 - 160,995,042 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004906   ⟹   NP_004897
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,117 - 159,756,319 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
Build 366160,068,142 - 160,097,341 (+)NCBI Archive
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,378 - 160,439,680 (+)NCBI
T2T-CHM13v2.06160,972,746 - 161,001,943 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152857   ⟹   NP_690596
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,506 - 159,749,419 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
Build 366160,068,610 - 160,090,443 (+)NCBI Archive
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,880 - 160,432,774 (+)NCBI
T2T-CHM13v2.06160,973,156 - 160,995,042 (+)NCBI
Sequence:
RefSeq Acc Id: NM_152858   ⟹   NP_690597
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,117 - 159,749,419 (+)NCBI
GRCh376160,147,712 - 160,177,351 (+)NCBI
Build 366160,068,142 - 160,090,443 (+)NCBI Archive
HuRef6157,617,339 - 157,646,781 (+)NCBI
CHM1_16160,410,378 - 160,432,774 (+)NCBI
T2T-CHM13v2.06160,972,746 - 160,995,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017011514   ⟹   XP_016867003
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,726,693 - 159,756,319 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017011515   ⟹   XP_016867004
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,739,859 - 159,756,319 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017011516   ⟹   XP_016867005
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,726,693 - 159,749,419 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047419578   ⟹   XP_047275534
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,506 - 159,756,319 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001257460 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257461 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257462 (Get FASTA)   NCBI Sequence Viewer  
  NP_004897 (Get FASTA)   NCBI Sequence Viewer  
  NP_690596 (Get FASTA)   NCBI Sequence Viewer  
  NP_690597 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867003 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867004 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867005 (Get FASTA)   NCBI Sequence Viewer  
  XP_047275534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH00383 (Get FASTA)   NCBI Sequence Viewer  
  AAH04432 (Get FASTA)   NCBI Sequence Viewer  
  AAH69192 (Get FASTA)   NCBI Sequence Viewer  
  AAK07548 (Get FASTA)   NCBI Sequence Viewer  
  AAK54764 (Get FASTA)   NCBI Sequence Viewer  
  BAA03495 (Get FASTA)   NCBI Sequence Viewer  
  BAF83543 (Get FASTA)   NCBI Sequence Viewer  
  BAG54579 (Get FASTA)   NCBI Sequence Viewer  
  CAC10188 (Get FASTA)   NCBI Sequence Viewer  
  CAC29495 (Get FASTA)   NCBI Sequence Viewer  
  CAH10537 (Get FASTA)   NCBI Sequence Viewer  
  EAW47622 (Get FASTA)   NCBI Sequence Viewer  
  EAW47623 (Get FASTA)   NCBI Sequence Viewer  
  EAW47624 (Get FASTA)   NCBI Sequence Viewer  
  EAW47625 (Get FASTA)   NCBI Sequence Viewer  
  EAW47626 (Get FASTA)   NCBI Sequence Viewer  
  EAW47627 (Get FASTA)   NCBI Sequence Viewer  
  EAW47628 (Get FASTA)   NCBI Sequence Viewer  
  Q15007 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_004897   ⟸   NM_004906
- Peptide Label: isoform 1
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_690597   ⟸   NM_152858
- Peptide Label: isoform 2
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_690596   ⟸   NM_152857
- Peptide Label: isoform 2
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257461   ⟸   NM_001270532
- Peptide Label: isoform 3
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot),   A0A087X1R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257460   ⟸   NM_001270531
- Peptide Label: isoform 1
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257462   ⟸   NM_001270533
- Peptide Label: isoform 3
- UniProtKB: Q15007 (UniProtKB/Swiss-Prot),   A0A087X1R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016867003   ⟸   XM_017011514
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016867005   ⟸   XM_017011516
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016867004   ⟸   XM_017011515
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000479438   ⟸   ENST00000621533
RefSeq Acc Id: ENSP00000497840   ⟸   ENST00000650096
RefSeq Acc Id: ENSP00000336911   ⟸   ENST00000337387
RefSeq Acc Id: ENSP00000484404   ⟸   ENST00000614346
RefSeq Acc Id: ENSP00000487338   ⟸   ENST00000631126
RefSeq Acc Id: ENSP00000351141   ⟸   ENST00000358372
RefSeq Acc Id: XP_047275534   ⟸   XM_047419578
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15007-F1-model_v2 AlphaFold Q15007 1-396 view protein structure

Promoters
RGD ID:7209583
Promoter ID:EPDNEW_H10537
Type:initiation region
Name:WTAP_2
Description:WT1 associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10535  EPDNEW_H10539  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,127 - 159,727,187EPDNEW
RGD ID:7209589
Promoter ID:EPDNEW_H10539
Type:initiation region
Name:WTAP_1
Description:WT1 associated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10535  EPDNEW_H10537  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386159,727,506 - 159,727,566EPDNEW
RGD ID:6804074
Promoter ID:HG_KWN:55653
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000401980,   NM_152857,   NM_152858,   OTTHUMT00000042905,   OTTHUMT00000042908,   UC003QSM.1,   UC010KJX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,067,911 - 160,068,707 (+)MPROMDB
RGD ID:6813130
Promoter ID:HG_ACW:70739
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:DARSNERBU.AAPR07-UNSPLICED,   WTAP.LAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,070,596 - 160,071,096 (+)MPROMDB
RGD ID:6805010
Promoter ID:HG_KWN:55655
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:UC003QSO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366160,094,206 - 160,094,706 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.3-26(chr6:155378049-163133499)x1 copy number loss See cases [RCV000137831] Chr6:155378049..163133499 [GRCh38]
Chr6:155699183..163554531 [GRCh37]
Chr6:155740875..163474521 [NCBI36]
Chr6:6q25.3-26
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27
pathogenic
GRCh38/hg38 6q23.2-27(chr6:133537271-165875545)x3 copy number gain See cases [RCV000143444] Chr6:133537271..165875545 [GRCh38]
Chr6:133858409..166289033 [GRCh37]
Chr6:133900102..166209023 [NCBI36]
Chr6:6q23.2-27
pathogenic
GRCh38/hg38 6q25.3-26(chr6:158585724-160899783)x3 copy number gain See cases [RCV000143618] Chr6:158585724..160899783 [GRCh38]
Chr6:159006756..161320815 [GRCh37]
Chr6:158926744..161240805 [NCBI36]
Chr6:6q25.3-26
uncertain significance
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27
pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27
pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27
pathogenic
GRCh37/hg19 6q25.3(chr6:157262571-160992289)x3 copy number gain not provided [RCV000848057] Chr6:157262571..160992289 [GRCh37]
Chr6:6q25.3
uncertain significance
GRCh37/hg19 6q25.3(chr6:160025206-160271483)x1 copy number loss not provided [RCV000846782] Chr6:160025206..160271483 [GRCh37]
Chr6:6q25.3
uncertain significance
GRCh37/hg19 6q25.3(chr6:160043162-160195268)x1 copy number loss not provided [RCV000845652] Chr6:160043162..160195268 [GRCh37]
Chr6:6q25.3
uncertain significance
GRCh37/hg19 6q25.3(chr6:159998877-160413982)x3 copy number gain not provided [RCV001258756] Chr6:159998877..160413982 [GRCh37]
Chr6:6q25.3
uncertain significance
GRCh37/hg19 6q25.2-26(chr6:153207930-164322346) copy number loss not specified [RCV002053640] Chr6:153207930..164322346 [GRCh37]
Chr6:6q25.2-26
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16846 AgrOrtholog
COSMIC WTAP COSMIC
Ensembl Genes ENSG00000146457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000336911 ENTREZGENE
  ENSP00000336911.4 UniProtKB/Swiss-Prot
  ENSP00000351141 ENTREZGENE
  ENSP00000351141.4 UniProtKB/Swiss-Prot
  ENSP00000479438 ENTREZGENE
  ENSP00000479438.1 UniProtKB/Swiss-Prot
  ENSP00000484404 ENTREZGENE
  ENSP00000484404.1 UniProtKB/TrEMBL
  ENSP00000487338 ENTREZGENE
  ENSP00000487338.1 UniProtKB/TrEMBL
  ENSP00000497840 ENTREZGENE
  ENSP00000497840.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000337387 ENTREZGENE
  ENST00000337387.4 UniProtKB/Swiss-Prot
  ENST00000358372 ENTREZGENE
  ENST00000358372.8 UniProtKB/Swiss-Prot
  ENST00000614346 ENTREZGENE
  ENST00000614346.4 UniProtKB/TrEMBL
  ENST00000621533 ENTREZGENE
  ENST00000621533.5 UniProtKB/Swiss-Prot
  ENST00000631126 ENTREZGENE
  ENST00000631126.2 UniProtKB/TrEMBL
  ENST00000650096 ENTREZGENE
  ENST00000650096.1 UniProtKB/Swiss-Prot
GTEx ENSG00000146457 GTEx
HGNC ID HGNC:16846 ENTREZGENE
Human Proteome Map WTAP Human Proteome Map
InterPro WTAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9589 UniProtKB/Swiss-Prot
NCBI Gene 9589 ENTREZGENE
OMIM 605442 OMIM
PANTHER PTHR15217 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Wtap UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134864847 PharmGKB
UniProt A0A087X1R4 ENTREZGENE, UniProtKB/TrEMBL
  FL2D_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5TCL8 UniProtKB/Swiss-Prot
  Q5TCL9 UniProtKB/Swiss-Prot
  Q96T28 UniProtKB/Swiss-Prot
  Q9BYJ7 UniProtKB/Swiss-Prot
  Q9H4E2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 WTAP  WT1 associated protein    Wilms tumor 1 associated protein  Symbol and/or name change 5135510 APPROVED