Zfp68 (zinc finger protein 68) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Zfp68 (zinc finger protein 68) Mus musculus
Analyze
No known orthologs.
Symbol: Zfp68
Name: zinc finger protein 68
RGD ID: 1321378
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and female reproductive system.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KRA; KRAB3; KRAZ2; mszf22; mszf49; Zfp6; Zfp7; Zfp70; zinc finger protein 70
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Gm18124  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,601,914 - 138,618,005 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,601,914 - 138,618,023 (-)EnsemblGRCm39 Ensembl
GRCm385138,603,652 - 138,619,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,603,652 - 138,619,761 (-)EnsemblGRCm38mm10GRCm38
MGSCv375139,044,880 - 139,060,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,835,908 - 138,849,515 (-)NCBIMGSCv36mm8
Celera5135,665,713 - 135,683,826 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, etal., Mamm Genome 1996 Jun;7(6):413-6.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2542606   PMID:7479878   PMID:9630514   PMID:10347202   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:12904583  
PMID:12930754   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18287559   PMID:18799693   PMID:20059953   PMID:20412781   PMID:21677750   PMID:21873635   PMID:21909369   PMID:22174793  


Genomics

Variants

.
Variants in Zfp68
625 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:892
Count of miRNA genes:413
Interacting mature miRNAs:456
Transcripts:ENSMUST00000063262, ENSMUST00000085852, ENSMUST00000110905, ENSMUST00000129832
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse

Markers in Region
C85178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv375139,045,974 - 139,046,084UniSTSGRCm37
Celera5135,666,811 - 135,666,921UniSTS
Celera5135,668,343 - 135,668,453UniSTS
Cytogenetic Map5G2UniSTS
cM Map579.0UniSTS
Whitehead/MRC_RH51675.55UniSTS
RH127148  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385138,604,715 - 138,604,951UniSTSGRCm38
MGSCv375139,045,943 - 139,046,179UniSTSGRCm37
Celera5135,666,780 - 135,667,026UniSTS
Celera5135,668,312 - 135,668,548UniSTS
Cytogenetic Map5G2UniSTS
cM Map579.0UniSTS
Whitehead/MRC_RH51675.47UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001163797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB010362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB024005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY088951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U29502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000063262   ⟹   ENSMUSP00000069615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,604,382 - 138,618,002 (-)Ensembl
GRCm38.p6 Ensembl5138,606,120 - 138,619,740 (-)Ensembl
RefSeq Acc Id: ENSMUST00000085852   ⟹   ENSMUSP00000083013
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,603,246 - 138,618,020 (-)Ensembl
GRCm38.p6 Ensembl5138,604,984 - 138,619,758 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110905   ⟹   ENSMUSP00000106530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,601,914 - 138,618,023 (-)Ensembl
GRCm38.p6 Ensembl5138,603,652 - 138,619,761 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129832   ⟹   ENSMUSP00000117037
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,610,329 - 138,617,915 (-)Ensembl
GRCm38.p6 Ensembl5138,612,067 - 138,619,653 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197654
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,604,378 - 138,605,319 (-)Ensembl
GRCm38.p6 Ensembl5138,606,116 - 138,607,057 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199066
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,614,449 - 138,618,000 (-)Ensembl
GRCm38.p6 Ensembl5138,616,187 - 138,619,738 (-)Ensembl
RefSeq Acc Id: NM_001044747   ⟹   NP_001038212
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,601,914 - 138,618,005 (-)NCBI
GRCm385138,603,652 - 138,619,743 (-)ENTREZGENE
MGSCv375139,044,880 - 139,060,971 (-)RGD
Celera5135,665,713 - 135,683,826 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001163797   ⟹   NP_001157269
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,601,914 - 138,618,005 (-)NCBI
GRCm385138,603,652 - 138,619,743 (-)ENTREZGENE
MGSCv375139,044,880 - 139,060,971 (-)RGD
Celera5135,665,713 - 135,683,826 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_013844   ⟹   NP_038872
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,601,914 - 138,618,005 (-)NCBI
GRCm385138,603,652 - 138,619,743 (-)ENTREZGENE
MGSCv375139,044,880 - 139,060,971 (-)RGD
Celera5135,665,713 - 135,683,826 (-)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001038212   ⟸   NM_001044747
- Peptide Label: isoform b
- UniProtKB: Q8BLK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_038872   ⟸   NM_013844
- Peptide Label: isoform a
- UniProtKB: Q9Z116 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001157269   ⟸   NM_001163797
- Peptide Label: isoform a
- UniProtKB: Q9Z116 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000106530   ⟸   ENSMUST00000110905
RefSeq Acc Id: ENSMUSP00000083013   ⟸   ENSMUST00000085852
RefSeq Acc Id: ENSMUSP00000117037   ⟸   ENSMUST00000129832
RefSeq Acc Id: ENSMUSP00000069615   ⟸   ENSMUST00000063262
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z116-F1-model_v2 AlphaFold Q9Z116 1-606 view protein structure

Promoters
RGD ID:6888526
Promoter ID:EPDNEW_M7714
Type:initiation region
Name:Zfp68_1
Description:Mus musculus zinc finger protein 68 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385138,619,709 - 138,619,769EPDNEW
RGD ID:6838678
Promoter ID:MM_KWN:44570
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000085852,   ENSMUST00000110902,   ENSMUST00000110903,   ENSMUST00000110905,   NM_001163797,   OTTMUST00000054805
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365139,060,616 - 139,061,116 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344427 AgrOrtholog
Ensembl Genes ENSMUSG00000058291 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000063262 ENTREZGENE
  ENSMUST00000063262.11 UniProtKB/TrEMBL
  ENSMUST00000085852 ENTREZGENE
  ENSMUST00000085852.11 UniProtKB/TrEMBL
  ENSMUST00000110905 ENTREZGENE
  ENSMUST00000110905.9 UniProtKB/TrEMBL
  ENSMUST00000129832.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:24135 UniProtKB/TrEMBL
MGD MGI:1344427 ENTREZGENE
NCBI Gene 24135 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  RIKEN CDNA 2810021J22 GENE UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 334 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 382 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 771 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 879 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 939 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_4 UniProtKB/TrEMBL
PhenoGen Zfp68 PhenoGen
PRINTS ZINCFINGER UniProtKB/TrEMBL
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt D3Z6N7_MOUSE UniProtKB/TrEMBL
  O88238_MOUSE UniProtKB/TrEMBL
  O88257_MOUSE UniProtKB/TrEMBL
  Q3U546_MOUSE UniProtKB/TrEMBL
  Q3UPV8_MOUSE UniProtKB/TrEMBL
  Q60910_MOUSE UniProtKB/TrEMBL
  Q8BLK6 ENTREZGENE, UniProtKB/TrEMBL
  Q8VEM6_MOUSE UniProtKB/TrEMBL
  Q9Z116 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Zfp68  zinc finger protein 68  Zfp70  zinc finger protein 70  Data merged from RGD:1609983 737654 PROVISIONAL