Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) - Rat Genome Database

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Gene: Serpinb6b (serine (or cysteine) peptidase inhibitor, clade B, member 6b) Mus musculus
Analyze
No known orthologs.
Symbol: Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
RGD ID: 1321361
MGI Page MGI
Description: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress and sensory perception of sound. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; eye surface region; gonad; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: NK1; NK13; ova; ovalbumin; serine (or cysteine) proteinase inhibitor, clade B, member 6b; serine protease inhibitor 12; Sp; Spi12
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Gm8436  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391333,140,797 - 33,163,050 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1333,149,192 - 33,163,050 (+)EnsemblGRCm39 Ensembl
GRCm381332,956,811 - 32,979,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,965,209 - 32,979,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371333,057,382 - 33,070,906 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361332,972,978 - 32,986,502 (+)NCBIMGSCv36mm8
Celera1333,167,013 - 33,180,537 (+)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9182575   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11863365   PMID:12477932   PMID:15611268   PMID:16141072   PMID:16141073   PMID:16175637   PMID:18391535  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:24172014   PMID:24505135   PMID:32391984  


Genomics

Variants

.
Variants in Serpinb6b
878 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:760
Count of miRNA genes:389
Interacting mature miRNAs:458
Transcripts:ENSMUST00000017184, ENSMUST00000110293, ENSMUST00000164541
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
14700800Syncq10_msynovial calcification QTL 10 (mouse)133244098333693983Mouse

Markers in Region
Serpinb6b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371333,070,100 - 33,070,177UniSTSGRCm37
Celera1333,179,731 - 33,179,808UniSTS
Cytogenetic Map13A3.3UniSTS
cM Map1312.3UniSTS
Serpinb6b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381332,978,231 - 32,978,308UniSTSGRCm38
MGSCv371333,070,100 - 33,070,177UniSTSGRCm37
Celera1333,179,731 - 33,179,808UniSTS
Cytogenetic Map13A3.3UniSTS
Serpinb6b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13A3.3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000017184   ⟹   ENSMUSP00000017184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1333,149,427 - 33,163,045 (+)Ensembl
GRCm38.p6 Ensembl1332,965,444 - 32,979,062 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110293   ⟹   ENSMUSP00000105922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1333,149,192 - 33,163,050 (+)Ensembl
GRCm38.p6 Ensembl1332,965,209 - 32,979,067 (+)Ensembl
RefSeq Acc Id: ENSMUST00000164541   ⟹   ENSMUSP00000152419
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1333,149,486 - 33,163,045 (+)Ensembl
GRCm38.p6 Ensembl1332,965,503 - 32,979,062 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1333,155,481 - 33,156,409 (+)Ensembl
GRCm38.p6 Ensembl1332,971,498 - 32,972,426 (+)Ensembl
RefSeq Acc Id: NM_011454   ⟹   NP_035584
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391333,149,244 - 33,163,050 (+)NCBI
GRCm381332,965,261 - 32,979,067 (+)NCBI
MGSCv371333,057,382 - 33,070,906 (+)RGD
Celera1333,167,013 - 33,180,537 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006516621   ⟹   XP_006516684
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391333,140,797 - 33,163,041 (+)NCBI
GRCm381332,956,811 - 32,979,058 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006516622   ⟹   XP_006516685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391333,152,817 - 33,163,041 (+)NCBI
GRCm381332,968,832 - 32,979,058 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035584   ⟸   NM_011454
- UniProtKB: O08804 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516684   ⟸   XM_006516621
- Peptide Label: isoform X1
- UniProtKB: O08804 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006516685   ⟸   XM_006516622
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000152419   ⟸   ENSMUST00000164541
RefSeq Acc Id: ENSMUSP00000105922   ⟸   ENSMUST00000110293
RefSeq Acc Id: ENSMUSP00000017184   ⟸   ENSMUST00000017184
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08804-F1-model_v2 AlphaFold O08804 1-377 view protein structure

Promoters
RGD ID:8680022
Promoter ID:EPDNEW_M18042
Type:initiation region
Name:Serpinb6b_1
Description:Mus musculus serine peptidase inhibitor, clade B, member 6b ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381332,965,502 - 32,965,562EPDNEW
RGD ID:6824376
Promoter ID:MM_KWN:13735
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung,   Spleen
Transcripts:ENSMUST00000110293,   NM_011454,   UC007PZY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361333,057,219 - 33,057,719 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894688 AgrOrtholog
Ensembl Genes ENSMUSG00000042842 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017184.10 UniProtKB/TrEMBL
  ENSMUST00000110293 ENTREZGENE
  ENSMUST00000110293.9 UniProtKB/TrEMBL
  ENSMUST00000164541.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report mmu:20708 UniProtKB/TrEMBL
MGD MGI:894688 ENTREZGENE
NCBI Gene 20708 ENTREZGENE
PANTHER NK13-RELATED UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb6b PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A1Y7VLD5_MOUSE UniProtKB/TrEMBL
  F7B9A0_MOUSE UniProtKB/TrEMBL
  O08804 ENTREZGENE, UniProtKB/TrEMBL
  Q3TAM4_MOUSE UniProtKB/TrEMBL