Cd163 (CD163 antigen) - Rat Genome Database

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Gene: Cd163 (CD163 antigen) Mus musculus
Analyze
Symbol: Cd163
Name: CD163 antigen
RGD ID: 1321259
MGI Page MGI
Description: Predicted to enable scaffold protein binding activity and scavenger receptor activity. Predicted to act upstream of or within endocytosis. Predicted to be located in external side of plasma membrane. Is expressed in several structures, including gut; immune system; male reproductive gland or organ; olfactory lobe; and quadriceps femoris muscle. Orthologous to human CD163 (CD163 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD163v2; CD163v3; scavenger receptor cysteine-rich type 1 protein M130
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,281,596 - 124,307,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,281,615 - 124,307,486 (+)EnsemblGRCm39 Ensembl
GRCm386124,304,636 - 124,330,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,304,656 - 124,330,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,254,669 - 124,280,545 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,270,275 - 124,296,146 (+)NCBIMGSCv36mm8
Celera6125,994,313 - 126,020,180 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abdominal Obesity  (ISO)
Actinobacillus Infections  (ISO)
acute pancreatitis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
brucellosis  (ISO)
carotid artery disease  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
developmental and epileptic encephalopathy 21  (ISO)
diverticulitis of colon  (ISO)
Ebola hemorrhagic fever  (ISO)
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, 9  (ISO)
Epstein-Barr virus infectious disease  (ISO)
Experimental Liver Cirrhosis  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
hemophagocytic lymphohistiocytosis  (ISO)
hepatocellular carcinoma  (ISO)
hidradenitis suppurativa  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Viral Hepatitis  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperphosphatemic Familial Tumoral Calcinosis 1  (ISO)
IgA glomerulonephritis  (ISO)
Insulin Resistance  (ISO)
Klippel-Feil syndrome 3  (ISO)
lepromatous leprosy  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
lung adenocarcinoma  (ISO)
lymphoproliferative syndrome 2  (ISO)
malaria  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multisystem inflammatory syndrome in children  (ISO)
nasopharynx carcinoma  (ISO)
obesity  (ISO)
ovarian cancer  (IMP)
peroxisome biogenesis disorder 2B  (ISO)
pneumonia  (ISO)
Porcine Reproductive and Respiratory Syndrome  (ISO)
pulmonary tuberculosis  (ISO)
Sepsis  (ISO)
Spinal Cord Compression  (ISO)
Spontaneous Abortions  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (IMP)
steatotic liver disease  (ISO)
Temtamy syndrome  (ISO)
traumatic brain injury  (ISO)
uveitis  (ISO)
visceral leishmaniasis  (ISO)
Whipple disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (EXP)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-penicillamine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diclofenac  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (ISO)
ethanol  (EXP)
flutamide  (ISO)
fructose  (EXP,ISO)
gadolinium trichloride  (ISO)
glucose  (EXP)
glyphosate  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
senecionine  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
topotecan  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
zinc sulfate  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. CD163 levels, pro- and anti-inflammatory cytokine secretion of monocytes in children with pulmonary tuberculosis. Aktas Cetin E, etal., Pediatr Pulmonol. 2017 May;52(5):675-683. doi: 10.1002/ppul.23617. Epub 2016 Sep 29.
2. Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma. Azambuja D, etal., Ann Oncol. 2012 Mar;23(3):736-742. doi: 10.1093/annonc/mdr157. Epub 2011 May 20.
3. Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. Beltrán LM, etal., PLoS One. 2014 Mar 4;9(3):e90541. doi: 10.1371/journal.pone.0090541. eCollection 2014.
4. Collagen deposition in chronic hidradenitis suppurativa: potential role for CD163+ macrophages. Byrd AS, etal., Br J Dermatol. 2018 Sep;179(3):792-794. doi: 10.1111/bjd.16600. Epub 2018 Jun 29.
5. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Chen W, etal., Mol Vis. 2009;15:619-28. Epub 2009 Mar 30.
6. Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis. Dighal A, etal., PLoS Negl Trop Dis. 2020 Feb 5;14(2):e0007991. doi: 10.1371/journal.pntd.0007991. eCollection 2020 Feb.
7. The macrophage activation marker CD163 is associated with IL28B genotype and hepatic inflammation in chronic hepatitis C virus infected patients. Dultz G, etal., J Viral Hepat. 2016 Apr;23(4):267-73. doi: 10.1111/jvh.12488. Epub 2015 Nov 10.
8. Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer. Etzerodt A, etal., J Exp Med. 2020 Apr 6;217(4). pii: 133611. doi: 10.1084/jem.20191869.
9. CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. Fischer-Riepe L, etal., J Allergy Clin Immunol. 2020 Nov;146(5):1137-1151. doi: 10.1016/j.jaci.2020.02.034. Epub 2020 Mar 19.
10. Serum soluble CD163 levels in patients with influenza-associated encephalopathy. Hasegawa S, etal., Brain Dev. 2013 Aug;35(7):626-9. doi: 10.1016/j.braindev.2012.10.005. Epub 2012 Nov 11.
11. Soluble CD163-Associated Dietary Patterns and the Risk of Metabolic Syndrome. Hu TY, etal., Nutrients. 2019 Apr 25;11(4). pii: nu11040940. doi: 10.3390/nu11040940.
12. M2-polarized tumour-associated macrophages in stroma correlate with poor prognosis and Epstein-Barr viral infection in nasopharyngeal carcinoma. Huang H, etal., Acta Otolaryngol. 2017 Aug;137(8):888-894. doi: 10.1080/00016489.2017.1296585. Epub 2017 Apr 10.
13. Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C. Kazankov K, etal., Hepatology. 2014 Aug;60(2):521-30. doi: 10.1002/hep.27129. Epub 2014 May 6.
14. Monocyte expression and soluble levels of the haemoglobin receptor (CD163/sCD163) and the mannose receptor (MR/sMR) in septic and critically ill non-septic ICU patients. Kjærgaard AG, etal., PLoS One. 2014 Mar 17;9(3):e92331. doi: 10.1371/journal.pone.0092331. eCollection 2014.
15. Clinical significance of CD163⁺ tumor-associated macrophages in patients with adult T-cell leukemia/lymphoma. Komohara Y, etal., Cancer Sci. 2013 Jul;104(7):945-51. doi: 10.1111/cas.12167. Epub 2013 May 9.
16. Levels of soluble CD163 and severity of malaria in children in Ghana. Kusi KA, etal., Clin Vaccine Immunol. 2008 Sep;15(9):1456-60. doi: 10.1128/CVI.00506-07. Epub 2008 Jul 16.
17. Expression of CD206 and CD163 on intermediate CD14++CD16+ monocytes are increased in hemorrhagic fever with renal syndrome and are correlated with disease severity. Li X, etal., Virus Res. 2018 Jul 15;253:92-102. doi: 10.1016/j.virusres.2018.05.021. Epub 2018 May 29.
18. Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans1. McElroy AK, etal., Emerg Infect Dis. 2019 Feb;25(2):290-298. doi: 10.3201/eid2502.181326.
19. Association between the haptoglobin and heme oxygenase 1 genetic profiles and soluble CD163 in susceptibility to and severity of human malaria. Mendonça VR, etal., Infect Immun. 2012 Apr;80(4):1445-54. doi: 10.1128/IAI.05933-11. Epub 2012 Jan 30.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. Impaired immune functions of monocytes and macrophages in Whipple's disease. Moos V, etal., Gastroenterology. 2010 Jan;138(1):210-20. doi: 10.1053/j.gastro.2009.07.066. Epub 2009 Aug 5.
22. CD163 favors Mycobacterium leprae survival and persistence by promoting anti-inflammatory pathways in lepromatous macrophages. Moura DF, etal., Eur J Immunol. 2012 Nov;42(11):2925-36. doi: 10.1002/eji.201142198. Epub 2012 Sep 14.
23. Serum levels of the soluble haemoglobin scavenger receptor CD163 in MPO-ANCA-associated renal vasculitis. Nagai M, etal., Scand J Rheumatol. 2016 Oct;45(5):397-403. doi: 10.3109/03009742.2015.1127410. Epub 2016 Apr 20.
24. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. Schaer DJ, etal., Eur J Haematol. 2005 Jan;74(1):6-10. doi: 10.1111/j.1600-0609.2004.00318.x.
28. sCD163 levels as a biomarker of disease severity in leprosy and visceral leishmaniasis. Silva RL, etal., PLoS Negl Trop Dis. 2017 Mar 29;11(3):e0005486. doi: 10.1371/journal.pntd.0005486. eCollection 2017 Mar.
29. Expression of substance P, neurokinin-1 receptor and immune markers in the brains of individuals with HIV-associated neuropathology. Spitsin S, etal., J Neurol Sci. 2013 Nov 15;334(1-2):18-23. doi: 10.1016/j.jns.2013.07.008. Epub 2013 Aug 2.
30. Serum levels of soluble CD163 and soluble CD14 following antibiotic therapy of patients with acute brucellosis. Sun H, etal., J Infect Dev Ctries. 2019 Aug 31;13(8):714-719. doi: 10.3855/jidc.10602.
31. Utility of Macrophage-activated Marker CD163 for Diagnosis and Prognosis in Pulmonary Tuberculosis. Suzuki Y, etal., Ann Am Thorac Soc. 2017 Jan;14(1):57-64. doi: 10.1513/AnnalsATS.201607-528OC.
32. Altered monocyte phenotype and dysregulated innate cytokine responses among people living with HIV and opioid-use disorder. Underwood ML, etal., AIDS. 2020 Feb 1;34(2):177-188. doi: 10.1097/QAD.0000000000002416.
33. Cellular neuroinflammation in a lateral forceps compression model of spinal cord injury. Vaughn CN, etal., Anat Rec (Hoboken). 2013 Aug;296(8):1229-46. doi: 10.1002/ar.22730. Epub 2013 Jun 17.
34. Association of steroid use with complicated sigmoid diverticulitis: potential role of activated CD68+/CD163+ macrophages. von Rahden BH, etal., Langenbecks Arch Surg. 2011 Aug;396(6):759-68. doi: 10.1007/s00423-011-0797-4. Epub 2011 May 7.
35. Expression of serum sCD163 in patients with liver diseases and inflammatory disorders. Wang J, etal., Int J Clin Exp Pathol. 2015 Jul 1;8(7):8419-25. eCollection 2015.
36. Elevated soluble CD163 plasma levels are associated with disease severity in patients with hemorrhagic fever with renal syndrome. Wang J, etal., PLoS One. 2014 Nov 13;9(11):e112127. doi: 10.1371/journal.pone.0112127. eCollection 2014.
37. Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure. Ye H, etal., World J Gastroenterol. 2013 May 14;19(18):2818-25. doi: 10.3748/wjg.v19.i18.2818.
38. Liver myofibroblasts up-regulate monocyte CD163 expression via PGE2 during hepatitis B induced liver failure. Zhang M, etal., J Transl Med. 2014 Mar 6;12:60. doi: 10.1186/1479-5876-12-60.
39. Soluble Scavenger Receptor CD163 Is Associated with Severe Acute Kidney Injury in Patients with Hantaan Virus Infection. Zhang Y, etal., Viral Immunol. 2015 May;28(4):241-6. doi: 10.1089/vim.2014.0112. Epub 2015 Mar 19.
40. Lesional accumulation of CD163+ macrophages/microglia in rat traumatic brain injury. Zhang Z, etal., Brain Res. 2012 Jun 21;1461:102-10. doi: 10.1016/j.brainres.2012.04.038. Epub 2012 Apr 27.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11345593   PMID:12477932   PMID:12698011   PMID:16141072   PMID:16141073   PMID:16624897   PMID:17494075   PMID:21267068  
PMID:21427223   PMID:21873635   PMID:22793784   PMID:22807450   PMID:24194600   PMID:24275664   PMID:26242746   PMID:26376364   PMID:27294203   PMID:27318131   PMID:27354410   PMID:27480124  
PMID:27626380   PMID:28358264   PMID:28464519   PMID:29457790   PMID:29610117   PMID:32710083   PMID:32924185   PMID:33004694   PMID:33005412   PMID:34146541   PMID:35306602   PMID:35338195  
PMID:36139418   PMID:36970754  


Genomics

Comparative Map Data
Cd163
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,281,596 - 124,307,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,281,615 - 124,307,486 (+)EnsemblGRCm39 Ensembl
GRCm386124,304,636 - 124,330,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,304,656 - 124,330,527 (+)EnsemblGRCm38mm10GRCm38
MGSCv376124,254,669 - 124,280,545 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366124,270,275 - 124,296,146 (+)NCBIMGSCv36mm8
Celera6125,994,313 - 126,020,180 (+)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.13NCBI
CD163
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,470,811 - 7,503,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,470,811 - 7,503,893 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,623,407 - 7,656,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,514,676 - 7,547,681 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,515,020 - 7,547,639NCBI
Celera129,198,918 - 9,231,725 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,436,319 - 7,469,334 (-)NCBIHuRef
CHM1_1127,622,379 - 7,655,379 (-)NCBICHM1_1
T2T-CHM13v2.0127,484,506 - 7,517,489 (-)NCBIT2T-CHM13v2.0
Cd163
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24157,085,080 - 157,118,470 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,085,093 - 157,117,878 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4163,335,769 - 163,369,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,118,672 - 159,152,022 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04157,764,068 - 157,797,421 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04156,752,063 - 156,785,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4156,752,082 - 156,785,467 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04223,769,336 - 223,802,725 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,394,833 - 160,428,208 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14160,639,152 - 160,669,269 (+)NCBI
Celera4145,861,321 - 145,894,692 (+)NCBICelera
Cytogenetic Map4q42NCBI
CD163
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11213,048,219 - 13,081,235 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,616,714 - 7,649,768 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,779,244 - 7,812,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,775,343 - 7,810,023 (-)Ensemblpanpan1.1panPan2
CD163
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,669,757 - 37,700,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,669,827 - 37,753,106 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,915,837 - 8,946,494 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02738,023,513 - 38,054,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,023,571 - 38,105,604 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12737,898,042 - 37,928,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02737,939,566 - 37,969,977 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,402,538 - 8,433,169 (-)NCBIUU_Cfam_GSD_1.0
CD163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,300,231 - 63,334,498 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1563,300,200 - 63,334,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD163
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,501,562 - 7,536,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,501,150 - 7,536,295 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666063667,595 - 702,654 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd163
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,975,747 - 4,000,349 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248603,976,746 - 4,000,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd163
615 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:224
Interacting mature miRNAs:233
Transcripts:ENSMUST00000032234, ENSMUST00000112541
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000032234   ⟹   ENSMUSP00000032234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,281,615 - 124,307,486 (+)Ensembl
GRCm38.p6 Ensembl6124,304,656 - 124,330,527 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112541   ⟹   ENSMUSP00000108160
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,281,659 - 124,307,486 (+)Ensembl
GRCm38.p6 Ensembl6124,304,700 - 124,330,527 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6124,297,446 - 124,307,478 (+)Ensembl
GRCm38.p6 Ensembl6124,320,487 - 124,330,519 (+)Ensembl
RefSeq Acc Id: NM_001170395   ⟹   NP_001163866
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,281,610 - 124,307,486 (+)NCBI
GRCm386124,304,651 - 124,330,527 (+)NCBI
MGSCv376124,254,669 - 124,280,545 (+)RGD
Celera6125,994,313 - 126,020,180 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_053094   ⟹   NP_444324
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,281,610 - 124,307,486 (+)NCBI
GRCm386124,304,651 - 124,330,527 (+)NCBI
MGSCv376124,254,669 - 124,280,545 (+)RGD
Celera6125,994,313 - 126,020,180 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506800   ⟹   XP_006506863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396124,281,596 - 124,307,488 (+)NCBI
GRCm386124,304,636 - 124,330,529 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_444324   ⟸   NM_053094
- Peptide Label: isoform 2 precursor
- UniProtKB: Q2VLH5 (UniProtKB/Swiss-Prot),   A6H691 (UniProtKB/Swiss-Prot),   Q99MX8 (UniProtKB/Swiss-Prot),   Q2VLH6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001163866   ⟸   NM_001170395
- Peptide Label: isoform 1 precursor
- UniProtKB: B7ZMW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506863   ⟸   XM_006506800
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000032234   ⟸   ENSMUST00000032234
RefSeq Acc Id: ENSMUSP00000108160   ⟸   ENSMUST00000112541
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2VLH6-F1-model_v2 AlphaFold Q2VLH6 1-1121 view protein structure

Promoters
RGD ID:6890952
Promoter ID:EPDNEW_M8927
Type:multiple initiation site
Name:Cd163_1
Description:Mus musculus CD163 antigen , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386124,304,658 - 124,304,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135946 AgrOrtholog
Ensembl Genes ENSMUSG00000008845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032234 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000112541 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:93671 UniProtKB/Swiss-Prot
MGD MGI:2135946 ENTREZGENE
NCBI Gene 93671 ENTREZGENE
PANTHER LCCL/LECTIN ADHESIVE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd163 PhenoGen
PRINTS SPERACTRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SRCR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6H691 ENTREZGENE
  B7ZMW6 ENTREZGENE, UniProtKB/TrEMBL
  C163A_MOUSE UniProtKB/Swiss-Prot
  Q2VLH5 ENTREZGENE
  Q2VLH6 ENTREZGENE
  Q99MX8 ENTREZGENE
UniProt Secondary A6H691 UniProtKB/Swiss-Prot
  Q2VLH5 UniProtKB/Swiss-Prot
  Q99MX8 UniProtKB/Swiss-Prot