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Gene: TLK1 (tousled like kinase 1) Homo sapiens
Symbol: TLK1
Name: tousled like kinase 1
Description: Exhibits ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin assembly or disassembly. Localizes to the nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KIAA0137; PKU-beta; serine threonine protein kinase; serine/threonine-protein kinase tousled-like 1; SNARE protein kinase SNAK; tousled-like kinase 1
Mus musculus (house mouse) : Tlk1 (tousled-like kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlk1 (tousled-like kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlk1 (tousled like kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TLK1 (tousled like kinase 1)
Canis lupus familiaris (dog) : TLK1 (tousled like kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlk1 (tousled like kinase 1)
Sus scrofa (pig) : TLK1 (tousled like kinase 1)
Chlorocebus sabaeus (green monkey) : TLK1 (tousled like kinase 1)
Heterocephalus glaber (naked mole-rat) : Tlk1 (tousled like kinase 1)
more info ...
Related Pseudogenes: TLK1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2170,990,823 - 171,231,314 (-)Ensembl
GRCh382170,990,823 - 171,231,293 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372171,847,333 - 172,087,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362171,556,814 - 171,725,206 (-)NCBINCBI36hg18NCBI36
Build 342171,674,076 - 171,842,467NCBI
Celera2165,463,993 - 165,633,992 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2163,735,825 - 163,862,446 (-)NCBIHuRef
CHM1_12171,853,562 - 172,094,367 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321237
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.