Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta)) Mus musculus
Symbol: Mccc2
Name: methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
Description: Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in coenzyme A metabolic process and leucine catabolic process. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Is expressed in metanephros and spinal cord. Orthologous to human MCCC2 (methylcrotonoyl-CoA carboxylase 2); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 4930552N12Rik; MCCase subunit beta; MCCB; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
Homo sapiens (human) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
Canis lupus familiaris (dog) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)
Sus scrofa (pig) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1399,948,530 - 100,015,639 (-)Ensembl
GRCm381399,948,532 - 100,015,639 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713100,718,487 - 100,785,594 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613101,048,783 - 101,115,886 (-)NCBImm8
Celera13103,601,615 - 103,669,283 (-)NCBICelera
Cytogenetic Map13 D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mccc2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321087
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.