SENP1 (SUMO specific peptidase 1) - Rat Genome Database

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Gene: SENP1 (SUMO specific peptidase 1) Homo sapiens
Analyze
Symbol: SENP1
Name: SUMO specific peptidase 1
RGD ID: 1321080
HGNC Page HGNC
Description: Enables SUMO-specific endopeptidase activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and protein desumoylation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in focal adhesion; nuclear membrane; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: sentrin-specific protease 1; sentrin/SUMO-specific protease SENP1; SUMO1/sentrin specific peptidase 1; SUMO1/sentrin specific protease 1; SuPr-2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,042,897 - 48,106,079 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,042,893 - 48,106,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,436,680 - 48,499,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,723,024 - 46,785,908 (-)NCBINCBI36hg18NCBI36
Build 341246,723,023 - 46,785,908NCBI
Celera1247,234,386 - 47,297,145 (-)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBIHuRef
CHM1_11248,402,545 - 48,465,523 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1087798   PMID:10652325   PMID:12466471   PMID:12477932   PMID:14563852   PMID:15105549   PMID:15199155   PMID:15487983   PMID:15489334   PMID:15546615   PMID:15701643   PMID:15820677  
PMID:15896780   PMID:15917269   PMID:15923632   PMID:16009940   PMID:16253240   PMID:16553580   PMID:16608850   PMID:16699503   PMID:16712526   PMID:16925949   PMID:17000875   PMID:17099698  
PMID:17591783   PMID:17704192   PMID:17981124   PMID:18029348   PMID:18219322   PMID:18474224   PMID:18538659   PMID:18616636   PMID:19116244   PMID:19322201   PMID:19339993   PMID:19622798  
PMID:20079608   PMID:20337593   PMID:20603076   PMID:20841360   PMID:21098080   PMID:21106093   PMID:21244100   PMID:21362625   PMID:21505236   PMID:21669491   PMID:21722636   PMID:21791615  
PMID:21832049   PMID:21873635   PMID:21965678   PMID:22194619   PMID:22370484   PMID:22412018   PMID:22493095   PMID:22688647   PMID:22733136   PMID:22748127   PMID:22878415   PMID:23002208  
PMID:23089540   PMID:23633483   PMID:23824909   PMID:24048451   PMID:24196834   PMID:24691972   PMID:24927568   PMID:25014244   PMID:25027693   PMID:25082844   PMID:25139051   PMID:25217324  
PMID:25225945   PMID:25263960   PMID:25425640   PMID:25430449   PMID:25446185   PMID:25476789   PMID:25645686   PMID:25691462   PMID:25791478   PMID:25816890   PMID:25891951   PMID:26186194  
PMID:26202067   PMID:26389676   PMID:26496610   PMID:26548925   PMID:26695141   PMID:26841866   PMID:26852650   PMID:26972000   PMID:27177472   PMID:27178176   PMID:27449295   PMID:27573572  
PMID:27576863   PMID:27693211   PMID:27741516   PMID:27821551   PMID:28417919   PMID:28514442   PMID:28550686   PMID:28569748   PMID:28576968   PMID:28611215   PMID:28620180   PMID:28718761  
PMID:28748780   PMID:28796315   PMID:29180619   PMID:29395067   PMID:29472234   PMID:29478914   PMID:29481054   PMID:29568061   PMID:30024791   PMID:30043429   PMID:30082317   PMID:30194290  
PMID:30226577   PMID:30305424   PMID:30472188   PMID:30612578   PMID:30622440   PMID:30921636   PMID:31040226   PMID:31045562   PMID:31056421   PMID:31186231   PMID:31586073   PMID:31753913  
PMID:31953908   PMID:32239614   PMID:32296183   PMID:32393512   PMID:32462635   PMID:32513696   PMID:32877691   PMID:33154164   PMID:33371766   PMID:33536335   PMID:33686713   PMID:33957083  
PMID:33961781   PMID:34049792   PMID:34079125  


Genomics

Comparative Map Data
SENP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,042,897 - 48,106,079 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,042,893 - 48,106,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,436,680 - 48,499,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,723,024 - 46,785,908 (-)NCBINCBI36hg18NCBI36
Build 341246,723,023 - 46,785,908NCBI
Celera1247,234,386 - 47,297,145 (-)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBIHuRef
CHM1_11248,402,545 - 48,465,523 (-)NCBICHM1_1
Senp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,936,625 - 97,991,625 (-)NCBIGRCm39mm39
GRCm39 Ensembl1597,936,625 - 97,991,625 (-)Ensembl
GRCm381598,038,744 - 98,093,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,038,744 - 98,093,744 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,871,660 - 97,923,836 (-)NCBIGRCm37mm9NCBIm37
MGSCv361597,869,450 - 97,921,344 (-)NCBImm8
Celera15100,168,159 - 100,220,260 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.04NCBI
Senp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,163,173 - 129,226,766 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7129,165,774 - 129,221,598 (-)Ensembl
Rnor_6.07139,626,444 - 139,684,587 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,523,690 - 139,542,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,630,515 - 139,675,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07138,763,261 - 138,811,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,746,791 - 136,808,933 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17136,824,107 - 136,895,190 (-)NCBI
Celera7125,653,981 - 125,702,739 (-)NCBICelera
Cytogenetic Map7q36NCBI
Senp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,926,548 - 6,979,230 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,924,445 - 6,978,482 (-)NCBIChiLan1.0ChiLan1.0
SENP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11241,499,046 - 41,561,097 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,507,348 - 41,558,969 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01240,624,200 - 40,689,837 (+)NCBIMhudiblu_PPA_v0panPan3
SENP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,664,750 - 6,719,257 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,664,818 - 6,714,479 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,586,894 - 39,641,870 (-)NCBI
ROS_Cfam_1.0276,732,302 - 6,787,340 (+)NCBI
UMICH_Zoey_3.1276,669,783 - 6,724,793 (+)NCBI
UNSW_CanFamBas_1.0276,704,515 - 6,759,712 (+)NCBI
UU_Cfam_GSD_1.02739,875,502 - 39,930,468 (-)NCBI
Senp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,175,011 - 67,229,945 (+)NCBI
SpeTri2.0NW_0049365125,932,594 - 5,989,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SENP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,423,383 - 78,476,195 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,419,849 - 78,476,315 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,597,603 - 81,650,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SENP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,272,371 - 44,334,787 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037202,045,058 - 202,109,387 (+)NCBIVero_WHO_p1.0
Senp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248164,173,321 - 4,231,711 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH47543  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,437,672 - 48,437,793UniSTSGRCh37
Build 361246,723,939 - 46,724,060RGDNCBI36
Celera1247,235,301 - 47,235,422RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,469,498 - 45,469,619UniSTS
GeneMap99-GB4 RH Map12197.09UniSTS
RH48837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,452,400 - 48,452,577UniSTSGRCh37
Build 361246,738,667 - 46,738,844RGDNCBI36
Celera1247,249,943 - 47,250,120RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,484,260 - 45,484,437UniSTS
GeneMap99-GB4 RH Map12213.15UniSTS
NCBI RH Map12390.8UniSTS
RH98806  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,437,496 - 48,437,677UniSTSGRCh37
Build 361246,723,763 - 46,723,944RGDNCBI36
Celera1247,235,125 - 47,235,306RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,469,322 - 45,469,503UniSTS
GeneMap99-GB4 RH Map12213.87UniSTS
RH119921  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,445,199 - 48,445,509UniSTSGRCh37
Build 361246,731,466 - 46,731,776RGDNCBI36
Celera1247,242,828 - 47,243,138RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,477,059 - 45,477,369UniSTS
TNG Radiation Hybrid Map1221709.0UniSTS
D12S1251E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,478,860 - 48,479,020UniSTSGRCh37
Build 361246,765,127 - 46,765,287RGDNCBI36
Celera1247,276,402 - 47,276,562RGD
Cytogenetic Map12q13.1UniSTS
Cytogenetic Map7q32UniSTS
HuRef1245,510,746 - 45,510,906UniSTS
D12S1814  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,481,506 - 48,481,762UniSTSGRCh37
Build 361246,767,773 - 46,768,029RGDNCBI36
Celera1247,279,048 - 47,279,304RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,513,392 - 45,513,648UniSTS
Stanford-G3 RH Map121833.0UniSTS
NCBI RH Map12357.8UniSTS
RH66140  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,452,604 - 48,452,749UniSTSGRCh37
Build 361246,738,871 - 46,739,016RGDNCBI36
Celera1247,250,147 - 47,250,292RGD
Cytogenetic Map12q13.1UniSTS
HuRef1245,484,464 - 45,484,609UniSTS
GeneMap99-GB4 RH Map12197.09UniSTS
D12S1957  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,505,749 - 128,505,867UniSTSGRCh37
GRCh371248,479,333 - 48,479,466UniSTSGRCh37
Build 367128,292,985 - 128,293,103RGDNCBI36
Celera1247,276,875 - 47,277,008UniSTS
Celera7123,302,263 - 123,302,381RGD
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map12q13.1UniSTS
Cytogenetic Map7q32UniSTS
HuRef1245,511,219 - 45,511,352UniSTS
HuRef7122,867,386 - 122,867,504UniSTS
CRA_TCAGchr7v27127,889,494 - 127,889,612UniSTS
Whitehead-YAC Contig Map12 UniSTS
ATP6V1F_3928  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377128,505,462 - 128,505,895UniSTSGRCh37
GRCh371248,479,034 - 48,479,494UniSTSGRCh37
Build 367128,292,698 - 128,293,131RGDNCBI36
Celera7123,301,976 - 123,302,409RGD
Celera1247,276,576 - 47,277,036UniSTS
HuRef7122,867,099 - 122,867,532UniSTS
HuRef1245,510,920 - 45,511,380UniSTS
CRA_TCAGchr7v27127,889,207 - 127,889,640UniSTS
SENP1_3815  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371248,436,824 - 48,437,716UniSTSGRCh37
Build 361246,723,091 - 46,723,983RGDNCBI36
Celera1247,234,453 - 47,235,345RGD
HuRef1245,468,650 - 45,469,542UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6752
Count of miRNA genes:1113
Interacting mature miRNAs:1366
Transcripts:ENST00000004980, ENST00000339976, ENST00000448372, ENST00000547181, ENST00000547886, ENST00000549518, ENST00000549595, ENST00000549882, ENST00000551330, ENST00000551358, ENST00000551592, ENST00000551798, ENST00000552189
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 266 357 188 33 799 35 1342 98 531 113 912 420 12 156 855 3
Low 2173 2620 1538 591 1142 430 3014 2095 3200 306 548 1193 163 1 1048 1933 3 2
Below cutoff 14 10 4 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001267594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001267595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_051991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_051992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC004801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF149770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL582855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI560893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX640784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000448372   ⟹   ENSP00000394791
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,042,974 - 48,105,808 (-)Ensembl
RefSeq Acc Id: ENST00000547181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,088,553 - 48,106,046 (-)Ensembl
RefSeq Acc Id: ENST00000547886
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,080,084 - 48,096,427 (-)Ensembl
RefSeq Acc Id: ENST00000549518   ⟹   ENSP00000447328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,042,897 - 48,106,079 (-)Ensembl
RefSeq Acc Id: ENST00000549595   ⟹   ENSP00000450076
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,045,322 - 48,101,472 (-)Ensembl
RefSeq Acc Id: ENST00000549882
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,097,737 - 48,106,066 (-)Ensembl
RefSeq Acc Id: ENST00000551358
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,063,631 - 48,065,680 (-)Ensembl
RefSeq Acc Id: ENST00000551592
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,080,093 - 48,098,034 (-)Ensembl
RefSeq Acc Id: ENST00000551798   ⟹   ENSP00000448597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,083,695 - 48,106,052 (-)Ensembl
RefSeq Acc Id: ENST00000552189   ⟹   ENSP00000447593
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,042,898 - 48,105,834 (-)Ensembl
RefSeq Acc Id: NM_001267594   ⟹   NP_001254523
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,897 - 48,106,079 (-)NCBI
GRCh371248,436,681 - 48,500,091 (-)NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBI
CHM1_11248,402,545 - 48,465,523 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001267595   ⟹   NP_001254524
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,897 - 48,105,855 (-)NCBI
GRCh371248,436,681 - 48,500,091 (-)NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBI
CHM1_11248,402,545 - 48,465,207 (-)NCBI
Sequence:
RefSeq Acc Id: NR_051991
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,898 - 48,105,992 (-)NCBI
GRCh371248,436,681 - 48,500,091 (-)NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBI
CHM1_11248,402,545 - 48,465,207 (-)NCBI
Sequence:
RefSeq Acc Id: NR_051992
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,897 - 48,105,855 (-)NCBI
GRCh371248,436,681 - 48,500,091 (-)NCBI
HuRef1245,468,507 - 45,531,571 (-)NCBI
CHM1_11248,402,545 - 48,465,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719361   ⟹   XP_006719424
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,817 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006719362   ⟹   XP_006719425
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,893 - 48,106,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538244   ⟹   XP_011536546
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,863 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011538245   ⟹   XP_011536547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019229   ⟹   XP_016874718
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019230   ⟹   XP_016874719
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019231   ⟹   XP_016874720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019232   ⟹   XP_016874721
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,106,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019233   ⟹   XP_016874722
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,893 - 48,105,847 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019234   ⟹   XP_016874723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019235   ⟹   XP_016874724
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,106,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019236   ⟹   XP_016874725
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,893 - 48,105,837 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019237   ⟹   XP_016874726
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,893 - 48,106,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019238   ⟹   XP_016874727
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019239   ⟹   XP_016874728
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,042,893 - 48,105,845 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017019240   ⟹   XP_016874729
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,043,191 - 48,105,747 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001254523   ⟸   NM_001267594
- UniProtKB: Q9P0U3 (UniProtKB/Swiss-Prot),   Q6N001 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001254524   ⟸   NM_001267595
- UniProtKB: Q9P0U3 (UniProtKB/Swiss-Prot),   Q6N001 (UniProtKB/TrEMBL),   Q7Z3G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006719425   ⟸   XM_006719362
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006719424   ⟸   XM_006719361
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011536547   ⟸   XM_011538245
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011536546   ⟸   XM_011538244
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016874726   ⟸   XM_017019237
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016874725   ⟸   XM_017019236
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_016874724   ⟸   XM_017019235
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016874721   ⟸   XM_017019232
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016874718   ⟸   XM_017019229
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016874722   ⟸   XM_017019233
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016874728   ⟸   XM_017019239
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016874729   ⟸   XM_017019240
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_016874727   ⟸   XM_017019238
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_016874723   ⟸   XM_017019234
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016874720   ⟸   XM_017019231
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016874719   ⟸   XM_017019230
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000447328   ⟸   ENST00000549518
RefSeq Acc Id: ENSP00000450076   ⟸   ENST00000549595
RefSeq Acc Id: ENSP00000448597   ⟸   ENST00000551798
RefSeq Acc Id: ENSP00000447593   ⟸   ENST00000552189
RefSeq Acc Id: ENSP00000394791   ⟸   ENST00000448372

Promoters
RGD ID:6790470
Promoter ID:HG_KWN:15495
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   Jurkat,   K562,   Lymphoblastoid
Transcripts:ENST00000004980,   NM_014554,   UC001RQX.1,   UC001RQY.1,   UC001RQZ.1,   UC009ZKX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361246,785,521 - 46,787,297 (-)MPROMDB
RGD ID:7223731
Promoter ID:EPDNEW_H17611
Type:initiation region
Name:SENP1_1
Description:SUMO1/sentrin specific peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17612  EPDNEW_H17613  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,105,852 - 48,105,912EPDNEW
RGD ID:7223733
Promoter ID:EPDNEW_H17612
Type:initiation region
Name:SENP1_3
Description:SUMO1/sentrin specific peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17611  EPDNEW_H17613  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,105,996 - 48,106,056EPDNEW
RGD ID:7223735
Promoter ID:EPDNEW_H17613
Type:initiation region
Name:SENP1_2
Description:SUMO1/sentrin specific peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17611  EPDNEW_H17612  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,106,308 - 48,106,368EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p11.21-q13.12(chr12:31886971-50360461)x3 copy number gain See cases [RCV000207454] Chr12:31886971..50360461 [GRCh37]
Chr12:12p11.21-q13.12
pathogenic
GRCh37/hg19 12q11-13.12(chr12:37857750-49791459)x3 copy number gain See cases [RCV000448835] Chr12:37857750..49791459 [GRCh37]
Chr12:12q11-13.12
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_001267594.2(SENP1):c.1211A>G (p.Gln404Arg) single nucleotide variant not provided [RCV000960934] Chr12:48065129 [GRCh38]
Chr12:48458912 [GRCh37]
Chr12:12q13.11
benign
NM_058195.4(CDKN2A):c.193+1G>A single nucleotide variant not provided [RCV001639948] Chr12:48106148 [GRCh38]
Chr12:48499931 [GRCh37]
Chr12:12q13.11
benign
NM_001267594.2(SENP1):c.238A>G (p.Ser80Gly) single nucleotide variant not provided [RCV000954141] Chr12:48088943 [GRCh38]
Chr12:48482726 [GRCh37]
Chr12:12q13.11
benign
NM_001035.3(RYR2):c.629C>T (p.Thr210Ile) single nucleotide variant not provided [RCV001587636] Chr12:48106115 [GRCh38]
Chr12:48499898 [GRCh37]
Chr12:12q13.11
likely benign
NC_000012.11:g.(?_48240430)_(48539491_?)dup duplication not provided [RCV001319329] Chr12:48240430..48539491 [GRCh37]
Chr12:12q13.11
uncertain significance
GRCh37/hg19 12q11-13.12(chr12:37873948-49578619)x3 copy number gain See cases [RCV001353185] Chr12:37873948..49578619 [GRCh37]
Chr12:12q11-13.12
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17927 AgrOrtholog
COSMIC SENP1 COSMIC
Ensembl Genes ENSG00000079387 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000394791 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000447328 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000447593 UniProtKB/TrEMBL
  ENSP00000448597 UniProtKB/TrEMBL
  ENSP00000450076 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000448372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000549518 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000549595 UniProtKB/Swiss-Prot
  ENST00000551798 UniProtKB/TrEMBL
  ENST00000552189 ENTREZGENE, UniProtKB/TrEMBL
GTEx ENSG00000079387 GTEx
HGNC ID HGNC:17927 ENTREZGENE
Human Proteome Map SENP1 Human Proteome Map
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C48_C UniProtKB/Swiss-Prot
KEGG Report hsa:29843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29843 ENTREZGENE
OMIM 612157 OMIM
Pfam Peptidase_C48 UniProtKB/Swiss-Prot
PharmGKB PA134947038 PharmGKB
PROSITE ULP_PROTEASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt F8VRZ8_HUMAN UniProtKB/TrEMBL
  F8W0I8_HUMAN UniProtKB/TrEMBL
  Q6N001 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z3G1 ENTREZGENE, UniProtKB/TrEMBL
  Q9P0U3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8K7P5 UniProtKB/Swiss-Prot
  Q86XC8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 SENP1  SUMO specific peptidase 1    SUMO1/sentrin specific peptidase 1  Symbol and/or name change 5135510 APPROVED