Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of CLK4 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of CLK4 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of CLK4 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of CLK4 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of CLK4 mRNA | CTD | PMID:35192832 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CLK4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CLK4 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CLK4 mRNA | CTD | PMID:21215274 | 2-palmitoylglycerol | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of CLK4 mRNA | CTD | PMID:37199045 | 5-iodotubercidin | decreases activity | ISO | CLK4 (Homo sapiens) | 6480464 | 5-iodotubercidin results in decreased activity of CLK4 protein | CTD | PMID:26953159 | 6-propyl-2-thiouracil | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of CLK4 mRNA | CTD | PMID:30047161 | acetamide | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of CLK4 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CLK4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CLK4 mRNA | CTD | PMID:32699268 | afimoxifene | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in decreased expression of CLK4 mRNA] | CTD | PMID:21233418 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of CLK4 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | CLK4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of CLK4 gene | CTD | PMID:27153756 | alpha-pinene | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CLK4 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of CLK4 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of CLK4 mRNA | CTD | PMID:30047161 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of CLK4 mRNA | CTD | PMID:23650126 | arsenous acid | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of CLK4 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | decreases methylation | ISO | CLK4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CLK4 5' UTR and Benzo(a)pyrene results in decreased methylation of CLK4 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of CLK4 mRNA | CTD | PMID:25181051 more ... | bisphenol A | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of CLK4 mRNA | CTD | PMID:35192832 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CLK4 mRNA | CTD | PMID:32156529 | bisphenol A | increases methylation | ISO | Clk4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of CLK4 gene | CTD | PMID:28505145 | cadmium dichloride | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of CLK4 mRNA | CTD | PMID:19010381 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | CGP 52608 | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CLK4 gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of CLK4 mRNA | CTD | PMID:37019170 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLK4 gene | CTD | PMID:20938992 | chrysene | increases expression | EXP | | 6480464 | chrysene results in increased expression of CLK4 mRNA | CTD | PMID:26377693 | cisplatin | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of CLK4 mRNA | CTD | PMID:27392435 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of CLK4 mRNA | CTD | PMID:20056891 | copper atom | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Copper results in increased expression of CLK4 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Copper results in increased expression of CLK4 mRNA | CTD | PMID:30556269 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of CLK4 mRNA | CTD | PMID:25270620 | cyclosporin A | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CLK4 mRNA | CTD | PMID:21632981 and PMID:25562108 | diarsenic trioxide | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of CLK4 mRNA | CTD | PMID:20458559 | dicrotophos | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of CLK4 mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of CLK4 mRNA | CTD | PMID:29803840 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of CLK4 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of CLK4 mRNA | CTD | PMID:23649840 | ferric oxide | increases expression | EXP | | 6480464 | ferric oxide analog results in increased expression of CLK4 mRNA | CTD | PMID:25086211 | fluoranthene | multiple interactions | EXP | | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of CLK4 mRNA | CTD | PMID:28329830 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLK4 gene more ... | CTD | PMID:20938992 and PMID:22206623 | formaldehyde | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of CLK4 mRNA | CTD | PMID:20655997 | FR900359 | increases phosphorylation | ISO | CLK4 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of CLK4 protein | CTD | PMID:37730182 | geldanamycin | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of CLK4 mRNA | CTD | PMID:26705709 | gentamycin | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of CLK4 mRNA | CTD | PMID:22061828 and PMID:33387578 | hydrogen peroxide | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of CLK4 mRNA | CTD | PMID:18951874 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CLK4 gene | CTD | PMID:20938992 | leflunomide | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | leflunomide results in increased expression of CLK4 mRNA | CTD | PMID:28988120 | methimazole | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of CLK4 mRNA | CTD | PMID:30047161 | methotrexate | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of CLK4 mRNA | CTD | PMID:24449571 | methyl methanesulfonate | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of CLK4 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of CLK4 mRNA | CTD | PMID:28001369 | ozone | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of CLK4 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CLK4 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of CLK4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of CLK4 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of CLK4 mRNA | CTD | PMID:27153767 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of CLK4 mRNA | CTD | PMID:19270015 | phorone | affects expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | phorone affects the expression of CLK4 mRNA | CTD | PMID:18198479 | resveratrol | multiple interactions | ISO | CLK4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of CLK4 mRNA | CTD | PMID:23557933 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of CLK4 mRNA | CTD | PMID:19073995 | silicon dioxide | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased expression of CLK4 mRNA | CTD | PMID:25351596 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of CLK4 mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CLK4 mRNA | CTD | PMID:28595984 and PMID:34032870 | sodium arsenite | affects expression | ISO | CLK4 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of CLK4 mRNA | CTD | PMID:29319823 | sulfadimethoxine | decreases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of CLK4 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of CLK4 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of CLK4 mRNA | CTD | PMID:17555576 | tetraphene | increases expression | EXP | | 6480464 | benz(a)anthracene results in increased expression of CLK4 mRNA | CTD | PMID:26377693 | thimerosal | increases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of CLK4 mRNA | CTD | PMID:27188386 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of CLK4 mRNA | CTD | PMID:29264374 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of CLK4 mRNA | CTD | PMID:33045310 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of CLK4 mRNA | CTD | PMID:21427059 | valproic acid | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CLK4 mRNA | CTD | PMID:23179753 more ... | vinclozolin | increases expression | ISO | Clk4 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of CLK4 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | CLK4 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of CLK4 mRNA | CTD | PMID:27188386 | |