Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Kdm2b (lysine (K)-specific demethylase 2B) Mus musculus
Analyze
Symbol: Kdm2b
Name: lysine (K)-specific demethylase 2B
Description: The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Histone-H3]-lysine-36 demethylase 1B; Cxxc2; E430001G17; F-box and leucine-rich repeat protein 10; F-box protein containing leucine repeats 10; F-box protein FBL10; F-box/LRR-repeat protein 10; Fbl10; Fbxl10; Jhdm1b; jmjC domain-containing histone demethylation protein 1B; KIAA3014; lysine-specific demethylase 2B; mKIAA3014; PCCX2
Orthologs:
Homo sapiens (human) : KDM2B (lysine demethylase 2B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdm2b (lysine demethylase 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm2b (lysine demethylase 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM2B (lysine demethylase 2B)
Canis lupus familiaris (dog) : KDM2B (lysine demethylase 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm2b (lysine demethylase 2B)
Sus scrofa (pig) : KDM2B (lysine demethylase 2B)
more info ...
Related Pseudogenes: Gm12397  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm385122,870,664 - 122,989,162 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375123,320,677 - 123,439,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv365123,131,285 - 123,249,709 (-)NCBImm8
Celera5119,957,271 - 120,084,235 (-)NCBICelera
Cytogenetic Map5 FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Kdm2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320990
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-05-14
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.