Gene: Kdm2b (lysine (K)-specific demethylase 2B) Mus musculus
Analyze
Symbol:
Kdm2b
Name:
lysine (K)-specific demethylase 2B
Description:
The protein encoded by this gene is a H3K36-specific histone demethylase, which contains an N-terminal jumonji C domain, a CxxC zinc finger domain, a plant homeodomain finger, an F-box, and eight leucine-rich repeats. Amongst its demonstrated functions, this protein plays roles in the suppression of premature cellular senescence, leukemia maintenance and development, maintenance of mouse embryonic stem cell pluripotency, and induced pluripotent stem cell generation. Mice homozygous for a targeted deletion of the zinc finger domain display embryonic lethality with development ceasing at approximately 7 to 8 days post coitum, demonstrating an essential role in early development. A pseudogene of this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
[Histone-H3]-lysine-36 demethylase 1B; Cxxc2; E430001G17; F-box and leucine-rich repeat protein 10; F-box protein containing leucine repeats 10; F-box protein FBL10; F-box/LRR-repeat protein 10; Fbl10; Fbxl10; Jhdm1b; jmjC domain-containing histone demethylation protein 1B; KIAA3014; lysine-specific demethylase 2B; mKIAA3014; PCCX2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
KDM2B (lysine demethylase 2B) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Kdm2b (lysine demethylase 2B) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Kdm2b (lysine demethylase 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
KDM2B (lysine demethylase 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
KDM2B (lysine demethylase 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Kdm2b (lysine demethylase 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
KDM2B (lysine demethylase 2B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
KDM2A (lysine demethylase 2A) HGNC
OrthoDB
Homo sapiens (human):
FBXL19 (F-box and leucine rich repeat protein 19) HGNC
Panther
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Kdm2b (lysine demethylase 2B)
Alliance
DIOPT (OMA, OrthoFinder, PANTHER, TreeFam)
Homo sapiens (human):
KDM2B (lysine demethylase 2B)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
kdm2ba (lysine (K)-specific demethylase 2Ba)
Alliance
DIOPT (PANTHER, ZFIN)
Danio rerio (zebrafish):
kdm2bb (lysine (K)-specific demethylase 2Bb)
Alliance
DIOPT (OMA, PANTHER, PhylomeDB, Roundup, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
JHD1
Alliance
DIOPT (OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
Kdm2
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
jhdm-1
Alliance
DIOPT (OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Related Pseudogenes:
Gm12397
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 5 122,870,664 - 122,989,162 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 5 123,320,677 - 123,439,101 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 5 123,131,285 - 123,249,709 (-) NCBI mm8 Celera 5 119,957,271 - 120,084,235 (-) NCBI Celera Cytogenetic Map 5 F NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Developmental Disabilities ISO RGD:1320989 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar microcephaly ISO RGD:1320989 8554872 ClinVar Annotator: match by term: Microcephaly ClinVar
Imported Annotations - CTD
schizophrenia ISO RGD:1320989 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21743468
(-)-demecolcine increases expression ISO RGD:1320989 6480464 Demecolcine results in increased expression of KDM2B mRNA CTD PMID:23649840 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1320989 6480464 Tetrachlorodibenzodioxin results in decreased expression of KDM2B mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of KDM2B mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:1310217 6480464 2, 4-dinitrotoluene affects the expression of KDM2B mRNA CTD PMID:21346803 6-propyl-2-thiouracil increases expression ISO RGD:1310217 6480464 Propylthiouracil results in increased expression of KDM2B mRNA CTD PMID:24780913 aflatoxin B1 increases expression ISO RGD:1320989 6480464 Aflatoxin B1 results in increased expression of KDM2B mRNA CTD PMID:22100608 aflatoxin B1 affects methylation ISO RGD:1320989 6480464 Aflatoxin B1 affects the methylation of KDM2B intron CTD PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:1320989 6480464 aflatoxin B2 results in decreased methylation of KDM2B intron CTD PMID:30157460 arsane affects methylation ISO RGD:1320989 6480464 Arsenic affects the methylation of KDM2B gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1320989 6480464 Arsenic affects the methylation of KDM2B gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:1320989 6480464 Arsenic affects the methylation of KDM2B gene CTD PMID:25304211 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to KDM2B promoter] CTD PMID:19654925 benzo[a]pyrene affects methylation ISO RGD:1320989 6480464 Benzo(a)pyrene affects the methylation of KDM2B intron CTD PMID:30157460 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1320989 6480464 7 more ... CTD PMID:20382639 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1310217 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KDM2B promoter CTD PMID:23359474 bisphenol A multiple interactions ISO RGD:1310217 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KDM2B promoter CTD PMID:23359474 bisphenol A increases methylation ISO RGD:1310217 6480464 bisphenol A results in increased methylation of KDM2B gene CTD PMID:28505145 bisphenol A increases expression ISO RGD:1310217 6480464 bisphenol A results in increased expression of KDM2B mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of KDM2B mRNA CTD PMID:26063408 calcitriol decreases expression ISO RGD:1320989 6480464 Calcitriol results in decreased expression of KDM2B mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1320989 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of KDM2B mRNA CTD PMID:21592394 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDM2B gene CTD PMID:20938992 copper atom multiple interactions ISO RGD:1320989 6480464 [NSC 689534 binds to Copper] which results in decreased expression of KDM2B mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1320989 6480464 [NSC 689534 binds to Copper] which results in decreased expression of KDM2B mRNA CTD PMID:20971185 copper(2+) multiple interactions ISO RGD:1320989 6480464 [NSC 689534 binds to Copper] which results in decreased expression of KDM2B mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:1320989 6480464 Copper Sulfate results in decreased expression of KDM2B mRNA CTD PMID:19549813 dibutyl phthalate multiple interactions ISO RGD:1310217 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KDM2B promoter CTD PMID:23359474 dicrotophos increases expression ISO RGD:1320989 6480464 dicrotophos results in increased expression of KDM2B mRNA CTD PMID:28302478 dorsomorphin multiple interactions ISO RGD:1320989 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1320989 6480464 Doxorubicin results in decreased expression of KDM2B mRNA CTD PMID:29803840 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDM2B gene CTD PMID:20938992 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KDM2B gene CTD PMID:20938992 menadione affects expression ISO RGD:1320989 6480464 Vitamin K 3 affects the expression of KDM2B mRNA CTD PMID:20044591 N-methylformamide decreases expression EXP 6480464 methylformamide analog results in decreased expression of KDM2B mRNA, methylformamide results in decreased expression of KDM2B mRNA CTD PMID:17040096 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of KDM2B mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1320989 6480464 Acetaminophen results in increased expression of KDM2B mRNA CTD PMID:22230336 , PMID:29067470 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of KDM2B mRNA CTD PMID:19136022 phenylmercury acetate decreases expression ISO RGD:1320989 6480464 Phenylmercuric Acetate results in decreased expression of KDM2B mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1320989 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KDM2B mRNA CTD PMID:27188386 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of KDM2B mRNA CTD PMID:19136022 pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in increased expression of KDM2B mRNA] CTD PMID:21318169 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of KDM2B mRNA CTD PMID:18301758 , PMID:21318169 SB 431542 multiple interactions ISO RGD:1320989 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1320989 6480464 Silicon Dioxide analog results in increased expression of KDM2B mRNA CTD PMID:23806026 tebuconazole decreases expression ISO RGD:1320989 6480464 tebuconazole results in decreased expression of KDM2B mRNA CTD PMID:30458266 testosterone multiple interactions ISO RGD:1320989 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of KDM2B mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1320989 6480464 Testosterone results in decreased expression of KDM2B mRNA CTD PMID:21592394 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of KDM2B mRNA CTD PMID:19042947 uranium atom affects expression ISO RGD:1320989 6480464 Uranium affects the expression of KDM2B mRNA CTD PMID:15672453 valproic acid affects expression ISO RGD:1320989 6480464 Valproic Acid affects the expression of KDM2B mRNA CTD PMID:25979313 valproic acid multiple interactions ISO RGD:1320989 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KDM2B mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1320989 6480464 Valproic Acid results in decreased expression of KDM2B mRNA CTD PMID:23179753 more ... valproic acid increases methylation ISO RGD:1320989 6480464 Valproic Acid results in increased methylation of KDM2B gene CTD PMID:29154799 vincristine increases expression ISO RGD:1320989 6480464 Vincristine results in increased expression of KDM2B mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:1320989 6480464 vorinostat results in decreased expression of KDM2B mRNA CTD PMID:27188386
Biological Process chromatin organization IEA UniProtKB-KW:KW-0156 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 embryonic camera-type eye morphogenesis IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 forebrain development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 fourth ventricle development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 hindbrain development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 histone H2A monoubiquitination ISO UniProtKB:Q8NHM5 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 histone H3-K36 demethylation IDA 2290270 MGI MGI:MGI:5433809 , PMID:21540074 histone H3-K36 demethylation ISO UniProtKB:Q8NHM5 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 initiation of neural tube closure IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 lateral ventricle development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 midbrain development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 midbrain-hindbrain boundary morphogenesis IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 negative regulation of neural precursor cell proliferation IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 negative regulation of neuron apoptotic process IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 negative regulation of transcription by RNA polymerase II IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 negative regulation of transcription by RNA polymerase II IDA 2290270 MGI MGI:MGI:5433809 , PMID:21540074 oxidation-reduction process IEA UniProtKB-KW:KW-0560 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 positive regulation of cell growth IDA 2290270 MGI MGI:MGI:5433809 , PMID:21540074 positive regulation of stem cell population maintenance IDA 2290270 MGI MGI:MGI:5433809 , PMID:21540074 spermatogenesis IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 third ventricle development IMP 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 Cellular Component chromosome IEA UniProtKB-KW:KW-0158 2290270 UniProt GO_REF:0000004, MGI:MGI:1354194 nucleus ISO UniProtKB:Q8NHM5 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 PcG protein complex colocalizes_with ISO UniProtKB:Q8NHM5 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Molecular Function dioxygenase activity IEA UniProtKB-KW:KW-0223 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 DNA binding IEA InterPro:IPR002857 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 histone demethylase activity TAS 2290270 BHF-UCL MGI:MGI:4949568 , PMID:21220025 histone demethylase activity (H3-K36 specific) ISO UniProtKB:Q8NHM5 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 oxidoreductase activity IEA UniProtKB-KW:KW-0560 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:Q9CQJ4 2290270 IntAct MGI:MGI:3715707 , PMID:17296600 RNA binding IEA UniProtKB-KW:KW-0694 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 2290270 MGI MGI:MGI:5317044 , PMID:21245044 rRNA binding IEA UniProtKB-KW:KW-0699 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 zinc ion binding IEA InterPro:IPR002857 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Gene-Chemical Interaction Annotations
