DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1) - Rat Genome Database

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Gene: DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides 1) Homo sapiens
Analyze
Symbol: DAPP1
Name: dual adaptor of phosphotyrosine and 3-phosphoinositides 1
RGD ID: 1320943
HGNC Page HGNC:16500
Description: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in signal transduction. Located in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: b lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; BAM32; DKFZp667E0716; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; dual adaptor of phosphotyrosine and 3-phosphoinositides; hDAPP1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,816,827 - 99,872,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,816,827 - 99,870,190 (+)EnsemblGRCh38hg38GRCh38
GRCh374100,737,984 - 100,791,347 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,957,013 - 101,010,334 (+)NCBINCBI36Build 36hg18NCBI36
Build 344101,095,167 - 101,148,489NCBI
Celera498,035,400 - 98,088,767 (+)NCBICelera
Cytogenetic Map4q23NCBI
HuRef496,476,303 - 96,529,671 (+)NCBIHuRef
CHM1_14100,714,487 - 100,767,854 (+)NCBICHM1_1
T2T-CHM13v2.04103,132,302 - 103,187,798 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (TAS)
membrane  (IEA)
plasma membrane  (IDA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:8889548   PMID:10432293   PMID:10770799   PMID:10880360   PMID:10983984   PMID:11001876   PMID:11042152   PMID:11524430   PMID:11781373   PMID:12101241   PMID:12477932   PMID:14563325  
PMID:15247305   PMID:15489334   PMID:15494510   PMID:16273093   PMID:17823121   PMID:21873635   PMID:21930970   PMID:21988832   PMID:25814554   PMID:32296183   PMID:32814053   PMID:33961781  


Genomics

Comparative Map Data
DAPP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,816,827 - 99,872,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,816,827 - 99,870,190 (+)EnsemblGRCh38hg38GRCh38
GRCh374100,737,984 - 100,791,347 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,957,013 - 101,010,334 (+)NCBINCBI36Build 36hg18NCBI36
Build 344101,095,167 - 101,148,489NCBI
Celera498,035,400 - 98,088,767 (+)NCBICelera
Cytogenetic Map4q23NCBI
HuRef496,476,303 - 96,529,671 (+)NCBIHuRef
CHM1_14100,714,487 - 100,767,854 (+)NCBICHM1_1
T2T-CHM13v2.04103,132,302 - 103,187,798 (+)NCBIT2T-CHM13v2.0
Dapp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393137,636,768 - 137,687,331 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3137,636,768 - 137,687,306 (-)EnsemblGRCm39 Ensembl
GRCm383137,931,007 - 137,981,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3137,931,007 - 137,981,545 (-)EnsemblGRCm38mm10GRCm38
MGSCv373137,593,970 - 137,644,513 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363137,868,992 - 137,918,911 (-)NCBIMGSCv36mm8
Celera3144,341,736 - 144,392,586 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map363.98NCBI
Dapp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,099,319 - 229,148,868 (-)NCBIGRCr8
mRatBN7.22226,425,890 - 226,475,445 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,425,898 - 226,475,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,180,628 - 234,230,053 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,080,370 - 232,129,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02226,945,028 - 226,994,460 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,175,346 - 243,224,883 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,175,346 - 243,224,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02261,723,376 - 261,772,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,423,487 - 235,474,068 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,411,898 - 235,460,789 (-)NCBI
Celera2218,592,238 - 218,641,599 (-)NCBICelera
Cytogenetic Map2q43NCBI
Dapp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554967,813,540 - 7,855,539 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554967,813,540 - 7,855,754 (-)NCBIChiLan1.0ChiLan1.0
DAPP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2397,898,439 - 97,953,780 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1498,182,243 - 98,237,589 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0492,240,003 - 92,292,624 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14102,901,213 - 102,956,357 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,901,220 - 102,954,210 (+)Ensemblpanpan1.1panPan2
DAPP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,765,401 - 21,812,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,766,526 - 21,812,608 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,083,207 - 20,131,390 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,986,478 - 22,034,664 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,987,581 - 22,037,991 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,962,957 - 22,011,140 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,750,131 - 21,798,306 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,069,897 - 18,118,126 (-)NCBIUU_Cfam_GSD_1.0
Dapp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530119,794,761 - 19,845,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365203,138,218 - 3,188,508 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365203,138,213 - 3,188,498 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8120,634,738 - 120,701,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18120,645,100 - 120,701,453 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28129,824,346 - 129,850,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,947,931 - 48,001,659 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,948,160 - 48,001,649 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603726,419,964 - 26,473,641 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dapp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248307,316,487 - 7,352,130 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248307,318,175 - 7,352,234 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DAPP1
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q23(chr4:97972342-100038125)x3 copy number gain See cases [RCV000051632] Chr4:97972342..100038125 [GRCh38]
Chr4:98893493..100959282 [GRCh37]
Chr4:99112516..101178305 [NCBI36]
Chr4:4q23
uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
NM_014395.2(DAPP1):c.248T>G (p.Phe83Cys) single nucleotide variant Malignant melanoma [RCV000074309] Chr4:99840312 [GRCh38]
Chr4:100761469 [GRCh37]
Chr4:100980492 [NCBI36]
Chr4:4q23
not provided
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24
pathogenic
GRCh38/hg38 4q22.1-24(chr4:92610413-101521991)x1 copy number loss See cases [RCV000140412] Chr4:92610413..101521991 [GRCh38]
Chr4:93531564..102443148 [GRCh37]
Chr4:93750587..102662171 [NCBI36]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1 copy number loss See cases [RCV000445741] Chr4:85805268..103678797 [GRCh37]
Chr4:4q21.23-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.1-24(chr4:92201567-103043808)x1 copy number loss See cases [RCV000511194] Chr4:92201567..103043808 [GRCh37]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.2-24(chr4:94692345-101308220)x1 copy number loss not provided [RCV001259285] Chr4:94692345..101308220 [GRCh37]
Chr4:4q22.2-24
likely pathogenic
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3 copy number gain not provided [RCV001827745] Chr4:95490755..109977216 [GRCh37]
Chr4:4q22.3-25
likely pathogenic
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
NM_014395.3(DAPP1):c.202G>A (p.Gly68Arg) single nucleotide variant Inborn genetic diseases [RCV002785078] Chr4:99835723 [GRCh38]
Chr4:100756880 [GRCh37]
Chr4:4q23
uncertain significance
NM_014395.3(DAPP1):c.780A>C (p.Gln260His) single nucleotide variant Inborn genetic diseases [RCV002823454] Chr4:99868122 [GRCh38]
Chr4:100789279 [GRCh37]
Chr4:4q23
uncertain significance
NM_014395.3(DAPP1):c.35G>C (p.Ser12Thr) single nucleotide variant Inborn genetic diseases [RCV002783606] Chr4:99816948 [GRCh38]
Chr4:100738105 [GRCh37]
Chr4:4q23
uncertain significance
NM_014395.3(DAPP1):c.43G>A (p.Asp15Asn) single nucleotide variant Inborn genetic diseases [RCV002747063] Chr4:99816956 [GRCh38]
Chr4:100738113 [GRCh37]
Chr4:4q23
uncertain significance
NM_014395.3(DAPP1):c.823C>T (p.Arg275Trp) single nucleotide variant Inborn genetic diseases [RCV002989379] Chr4:99868165 [GRCh38]
Chr4:100789322 [GRCh37]
Chr4:4q23
uncertain significance
NM_014395.3(DAPP1):c.129T>A (p.His43Gln) single nucleotide variant Inborn genetic diseases [RCV003211009] Chr4:99835650 [GRCh38]
Chr4:100756807 [GRCh37]
Chr4:4q23
uncertain significance
GRCh37/hg19 4q23-24(chr4:100542119-103793167)x1 copy number loss not provided [RCV003485432] Chr4:100542119..103793167 [GRCh37]
Chr4:4q23-24
pathogenic
GRCh37/hg19 4q23(chr4:100682937-100845088)x1 copy number loss not provided [RCV003485433] Chr4:100682937..100845088 [GRCh37]
Chr4:4q23
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1223
Count of miRNA genes:643
Interacting mature miRNAs:712
Transcripts:ENST00000296414, ENST00000507994, ENST00000512369, ENST00000514301
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-67302  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,789,882 - 100,790,066UniSTSGRCh37
Build 364101,008,905 - 101,009,089RGDNCBI36
Celera498,087,302 - 98,087,486RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,528,206 - 96,528,390UniSTS
RH121432  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,781,770 - 100,781,968UniSTSGRCh37
Build 364101,000,793 - 101,000,991RGDNCBI36
Celera498,079,188 - 98,079,386RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,520,091 - 96,520,289UniSTS
TNG Radiation Hybrid Map1727622.0UniSTS
RH122503  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,763,211 - 100,763,523UniSTSGRCh37
Build 364100,982,234 - 100,982,546RGDNCBI36
Celera498,060,629 - 98,060,941RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,501,532 - 96,501,844UniSTS
SHGC-133078  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,789,481 - 100,789,781UniSTSGRCh37
Build 364101,008,504 - 101,008,804RGDNCBI36
Celera498,086,901 - 98,087,201RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,527,805 - 96,528,105UniSTS
TNG Radiation Hybrid Map460321.0UniSTS
SHGC-145018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,737,638 - 100,737,970UniSTSGRCh37
Build 364100,956,661 - 100,956,993RGDNCBI36
Celera498,035,057 - 98,035,389RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,475,960 - 96,476,292UniSTS
SHGC-64080  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,789,518 - 100,789,672UniSTSGRCh37
Build 364101,008,541 - 101,008,695RGDNCBI36
Celera498,086,938 - 98,087,092RGD
Cytogenetic Map4q25-q27UniSTS
HuRef496,527,842 - 96,527,996UniSTS
DAPP1_4668  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh374100,789,988 - 100,790,808UniSTSGRCh37
Build 364101,009,011 - 101,009,831RGDNCBI36
Celera498,087,408 - 98,088,228RGD
HuRef496,528,312 - 96,529,132UniSTS
RH36905  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map12q24.11UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1p12UniSTS
Cytogenetic Map10p12.33UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map18p11.3-p11.2UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map10q24.32UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map3q27-q28UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map5p13.2UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map14q13.2UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map20p11.23UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map3q12.2-q12.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map12q24.2-q24.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map11q12-q13.1UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map9q31.1UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map10q21UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map4q25-q27UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map10q24.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map1p21.3UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map3p25.1UniSTS
Cytogenetic Map10q25-q26UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map7p14UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map16q22.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 106 441 25 93 1429 8 1167 8 2 25 260 243 99 11 623 2
Low 1630 1354 1007 328 498 253 2175 953 1299 241 798 1037 76 1 1134 1439 4 2
Below cutoff 697 1182 688 200 22 201 987 1222 2387 140 395 323 59 724

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001306151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011531840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011531842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011531843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054349680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054349681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054349682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054349683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001741200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007096391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF161551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF163254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF186022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM968883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA428013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN995752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000296414   ⟹   ENSP00000296414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl499,816,833 - 99,870,154 (+)Ensembl
RefSeq Acc Id: ENST00000507994
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl499,816,850 - 99,864,286 (+)Ensembl
RefSeq Acc Id: ENST00000512369   ⟹   ENSP00000423602
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl499,816,827 - 99,870,190 (+)Ensembl
RefSeq Acc Id: ENST00000514301
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl499,864,872 - 99,869,614 (+)Ensembl
RefSeq Acc Id: NM_001306151   ⟹   NP_001293080
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,870,190 (+)NCBI
CHM1_14100,714,496 - 100,767,854 (+)NCBI
T2T-CHM13v2.04103,132,302 - 103,185,673 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014395   ⟹   NP_055210
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,870,190 (+)NCBI
GRCh374100,737,957 - 100,791,347 (+)NCBI
Build 364100,957,013 - 101,010,334 (+)NCBI Archive
HuRef496,476,303 - 96,529,671 (+)ENTREZGENE
CHM1_14100,714,487 - 100,767,854 (+)NCBI
T2T-CHM13v2.04103,132,302 - 103,185,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011531840   ⟹   XP_011530142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,872,333 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011531843   ⟹   XP_011530145
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,843,001 - 99,870,190 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008023   ⟹   XP_016863512
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,866,618 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008024   ⟹   XP_016863513
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,872,333 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054349680   ⟹   XP_054205655
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04103,132,302 - 103,187,798 (+)NCBI
RefSeq Acc Id: XM_054349681   ⟹   XP_054205656
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04103,132,302 - 103,187,759 (+)NCBI
RefSeq Acc Id: XM_054349682   ⟹   XP_054205657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04103,132,302 - 103,182,101 (+)NCBI
RefSeq Acc Id: XM_054349683   ⟹   XP_054205658
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04103,158,372 - 103,185,673 (+)NCBI
RefSeq Acc Id: XR_007096391
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,827 - 99,866,092 (+)NCBI
RefSeq Acc Id: XR_008486964
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.04103,132,302 - 103,181,575 (+)NCBI
RefSeq Acc Id: NP_055210   ⟸   NM_014395
- Peptide Label: isoform 1
- UniProtKB: Q8TCK5 (UniProtKB/Swiss-Prot),   Q9UHF2 (UniProtKB/Swiss-Prot),   Q9UN19 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011530142   ⟸   XM_011531840
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011530145   ⟸   XM_011531843
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001293080   ⟸   NM_001306151
- Peptide Label: isoform 2
- UniProtKB: J3KNB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016863513   ⟸   XM_017008024
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016863512   ⟸   XM_017008023
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000296414   ⟸   ENST00000296414
RefSeq Acc Id: ENSP00000423602   ⟸   ENST00000512369
RefSeq Acc Id: XP_054205655   ⟸   XM_054349680
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054205656   ⟸   XM_054349681
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054205657   ⟸   XM_054349682
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054205658   ⟸   XM_054349683
- Peptide Label: isoform X3
Protein Domains
PH   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UN19-F1-model_v2 AlphaFold Q9UN19 1-280 view protein structure

Promoters
RGD ID:6868114
Promoter ID:EPDNEW_H7222
Type:multiple initiation site
Name:DAPP1_2
Description:dual adaptor of phosphotyrosine and 3-phosphoinositides 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7223  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,810,673 - 99,810,733EPDNEW
RGD ID:6868116
Promoter ID:EPDNEW_H7223
Type:initiation region
Name:DAPP1_1
Description:dual adaptor of phosphotyrosine and 3-phosphoinositides 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7222  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,816,830 - 99,816,890EPDNEW
RGD ID:6802152
Promoter ID:HG_KWN:48799
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_014395,   UC010ILH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,956,679 - 100,957,179 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16500 AgrOrtholog
COSMIC DAPP1 COSMIC
Ensembl Genes ENSG00000070190 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000296414 ENTREZGENE
  ENST00000296414.11 UniProtKB/TrEMBL
  ENST00000512369 ENTREZGENE
  ENST00000512369.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000070190 GTEx
HGNC ID HGNC:16500 ENTREZGENE
Human Proteome Map DAPP1 Human Proteome Map
InterPro DAPP1_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27071 UniProtKB/Swiss-Prot
NCBI Gene 27071 ENTREZGENE
OMIM 605768 OMIM
PANTHER DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TANDEM PH DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27145 PharmGKB
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DAPP1_HUMAN UniProtKB/Swiss-Prot
  J3KNB3 ENTREZGENE, UniProtKB/TrEMBL
  Q8TCK5 ENTREZGENE
  Q9UHF2 ENTREZGENE
  Q9UN19 ENTREZGENE
UniProt Secondary Q8TCK5 UniProtKB/Swiss-Prot
  Q9UHF2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 DAPP1  dual adaptor of phosphotyrosine and 3-phosphoinositides 1    dual adaptor of phosphotyrosine and 3-phosphoinositides  Symbol and/or name change 5135510 APPROVED