Htd2 (hydroxyacyl-thioester dehydratase type 2) - Rat Genome Database

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Gene: Htd2 (hydroxyacyl-thioester dehydratase type 2) Mus musculus
Analyze
Symbol: Htd2 (Ensembl: Rpp14)
Name: hydroxyacyl-thioester dehydratase type 2 (Ensembl:ribonuclease P 14 subunit)
RGD ID: 13208237
MGI Page MGI
Description: Acts upstream of or within lipoate biosynthetic process. Located in mitochondrion; INTERACTS WITH sodium arsenite.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hydroxyacyl-thioester dehydratase type 2, mitochondrial
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,377,937 - 14,389,436 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,377,939 - 14,389,406 (-)EnsemblGRCm39 Ensembl
GRCm38148,080,313 - 8,091,846 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl148,080,367 - 8,091,834 (+)EnsemblGRCm38mm10GRCm38
Cytogenetic Map14A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IDA)
nucleolus  (ISO)

References
Additional References at PubMed
PMID:8889548   PMID:12040188   PMID:33774475  


Genomics

Comparative Map Data
Htd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,377,937 - 14,389,436 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,377,939 - 14,389,406 (-)EnsemblGRCm39 Ensembl
GRCm38148,080,313 - 8,091,846 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl148,080,367 - 8,091,834 (+)EnsemblGRCm38mm10GRCm38
Cytogenetic Map14A1NCBI
HTD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,306,245 - 58,320,193 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,306,262 - 58,320,193 (+)EnsemblGRCh38hg38GRCh38
GRCh37358,291,972 - 58,305,920 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p14.3NCBI
T2T-CHM13v2.0358,346,652 - 58,360,600 (+)NCBIT2T-CHM13v2.0
Htd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82107,151,876 - 107,152,337 (+)NCBIGRCr8
mRatBN7.22105,222,958 - 105,223,419 (+)NCBImRatBN7.2mRatBN7.2
Cytogenetic Map2q24NCBI
RPP14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,274,288 - 58,292,367 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,279,062 - 58,291,137 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,239,048 - 58,252,810 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,653,220 - 59,666,302 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,664,088 - 59,664,684 (+)Ensemblpanpan1.1panPan2
PanPan1.1 Ensembl359,653,220 - 59,666,531 (+)Ensemblpanpan1.1panPan2
HTD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,280,815 - 32,288,844 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,205,831 - 32,213,858 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,548,965 - 32,556,984 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,546,560 - 32,562,139 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,005,272 - 32,013,298 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,361,810 - 32,369,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,533,416 - 32,541,444 (-)NCBIUU_Cfam_GSD_1.0
Htd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,529,612 - 169,532,647 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,670,676 - 2,671,179 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,669,483 - 2,671,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1340,071,665 - 40,076,049 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11340,062,149 - 40,078,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21344,022,445 - 44,033,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,600,138 - 19,601,722 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041147,223,387 - 147,236,364 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Htd2
236 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
13824988Phsq1_mpercent hyperactivated sperm QTL 1 (mouse)14305000119469772Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse


Sequence


Ensembl Acc Id: ENSMUST00000023924   ⟹   ENSMUSP00000023924
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1414,377,939 - 14,389,406 (-)Ensembl
GRCm38.p6 Ensembl148,080,367 - 8,091,834 (+)Ensembl
Ensembl Acc Id: ENSMUST00000180369   ⟹   ENSMUSP00000136494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1414,379,219 - 14,379,695 (-)Ensembl
GRCm38.p6 Ensembl148,090,078 - 8,090,554 (+)Ensembl
RefSeq Acc Id: NM_001348727   ⟹   NP_001335656
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391414,377,937 - 14,389,436 (-)NCBI
GRCm38148,080,313 - 8,091,846 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001335656 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL20581 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000136494
  ENSMUSP00000136494.2
RefSeq Acc Id: NP_001335656   ⟸   NM_001348727
- UniProtKB: J3QMX0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000023924   ⟸   ENSMUST00000023924
Ensembl Acc Id: ENSMUSP00000136494   ⟸   ENSMUST00000180369
Protein Domains
MaoC-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000023156 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000180369 ENTREZGENE
  ENSMUST00000180369.2 UniProtKB/TrEMBL
Gene3D-CATH Hotdog Thioesterase UniProtKB/TrEMBL
InterPro HotDog_dom_sf UniProtKB/TrEMBL
  MaoC-like_dom UniProtKB/TrEMBL
  UPF0336/Enoyl-CoA_hydratase UniProtKB/TrEMBL
KEGG Report mmu:109729085 UniProtKB/TrEMBL
MGD MGI:5827763 ENTREZGENE
NCBI Gene Htd2 ENTREZGENE
PANTHER HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL UniProtKB/TrEMBL
  HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
Pfam MaoC_dehydratas UniProtKB/TrEMBL
PhenoGen Htd2 PhenoGen
Superfamily-SCOP Thioesterase/thiol ester dehydrase-isomerase UniProtKB/TrEMBL
UniProt J3QMX0 ENTREZGENE, UniProtKB/TrEMBL