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Gene: TMC2 (transmembrane channel like 2) Homo sapiens
Symbol: TMC2
Name: transmembrane channel like 2
Description: Predicted to have mechanosensitive ion channel activity and voltage-gated calcium channel activity. Involved in detection of mechanical stimulus involved in sensory perception of sound. Predicted to localize to integral component of plasma membrane and stereocilium tip.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C20orf145; dJ686C3.3; transmembrane channel-like 2; transmembrane channel-like protein 2; transmembrane cochlear-expressed gene 2; transmembrane cochlear-expressed protein 2; transmembrane, cochlear expressed, 2
Mus musculus (house mouse) : Tmc2 (transmembrane channel-like gene family 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tmc2 (transmembrane channel-like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmc2 (transmembrane channel like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TMC2 (transmembrane channel like 2)
Canis lupus familiaris (dog) : TMC2 (transmembrane channel like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmc2 (transmembrane channel like 2)
Sus scrofa (pig) : TMC2 (transmembrane channel like 2)
Chlorocebus sabaeus (African green monkey) : TMC2 (transmembrane channel like 2)
Heterocephalus glaber (naked mole-rat) : Tmc2 (transmembrane channel like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl202,536,607 - 2,641,784 (+)EnsemblGRCh38hg38GRCh38
GRCh38202,536,607 - 2,641,784 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37202,517,253 - 2,622,494 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,465,253 - 2,570,430 (+)NCBINCBI36hg18NCBI36
Build 34202,465,252 - 2,570,430NCBI
Celera202,581,686 - 2,686,898 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef202,467,102 - 2,571,627 (+)NCBIHuRef
CHM1_1202,517,614 - 2,622,843 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TMC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320766
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.