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Gene: TGS1 (trimethylguanosine synthase 1) Homo sapiens
Symbol: TGS1
Name: trimethylguanosine synthase 1
Description: Exhibits RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Localizes to the cytosol and nucleus; INTERACTS WITH aflatoxin B1; benzo[a]pyrene diol epoxide I; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cap-specific guanine-N2 methyltransferase; CLL-associated antigen KW-2; DKFZp762A163; FLJ22995; hepatocellular carcinoma-associated antigen 137; NCOA6IP; nuclear receptor coactivator 6 interacting protein; nuclear receptor coactivator 6-interacting protein; PIMT; PIPMT; PRIP-interacting protein PIPMT; PRIP-interacting protein with methyltransferase domain; PRIP-interacting protein with methyltransferase motif; SEREX-defined; trimethylguanosine synthase; trimethylguanosine synthase homolog
Mus musculus (house mouse) : Tgs1 (trimethylguanosine synthase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgs1 (trimethylguanosine synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgs1 (trimethylguanosine synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGS1 (trimethylguanosine synthase 1)
Canis lupus familiaris (dog) : TGS1 (trimethylguanosine synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgs1 (trimethylguanosine synthase 1)
Sus scrofa (pig) : TGS1 (trimethylguanosine synthase 1)
Chlorocebus sabaeus (green monkey) : TGS1 (trimethylguanosine synthase 1)
Heterocephalus glaber (naked mole-rat) : Tgs1 (trimethylguanosine synthase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl855,773,446 - 55,826,445 (+)Ensembl
GRCh38855,773,446 - 55,826,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37856,685,791 - 56,738,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,848,345 - 56,900,559 (+)NCBINCBI36hg18NCBI36
Build 34856,848,254 - 56,900,557NCBI
Celera852,677,058 - 52,729,766 (+)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,154,245 - 52,206,403 (+)NCBIHuRef
CHM1_1856,737,385 - 56,790,600 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TGS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320573
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.