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Gene: Sim1 (single-minded family bHLH transcription factor 1) Mus musculus
Symbol: Sim1
Name: single-minded family bHLH transcription factor 1
RGD ID: 1320568
Description: Exhibits protein heterodimerization activity. Involved in regulation of transcription, DNA-templated and ureteric bud development. Localizes to nucleus. Is expressed in several structures, including central nervous system; limb bud; metanephros; paraxial mesenchyme; and sensory organ. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1); INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bHLHe1; bHLHe14; mSIM1; single-minded 1; single-minded homolog 1; single-minded homolog 1 (Drosophila)
Homo sapiens (human) : SIM1 (SIM bHLH transcription factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sim1 (SIM bHLH transcription factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sim1 (SIM bHLH transcription factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIM1 (SIM bHLH transcription factor 1)
Canis lupus familiaris (dog) : SIM1 (SIM bHLH transcription factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sim1 (SIM bHLH transcription factor 1)
Sus scrofa (pig) : SIM1 (SIM bHLH transcription factor 1)
Chlorocebus sabaeus (African green monkey) : SIM1 (SIM bHLH transcription factor 1)
Heterocephalus glaber (naked mole-rat) : Sim1 (SIM bHLH transcription factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391050,770,794 - 50,865,252 (+)NCBI
GRCm381050,894,698 - 50,989,156 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1050,894,754 - 50,989,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv371050,615,457 - 50,708,958 (+)NCBIGRCm37mm9NCBIm37
MGSCv361050,584,066 - 50,677,567 (+)NCBImm8
Celera1051,744,683 - 51,838,475 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1024.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Sim1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320568
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.