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Gene: Trpm6 (transient receptor potential cation channel, subfamily M, member 6) Mus musculus
Symbol: Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Description: Exhibits cation channel activity. Involved in metal ion transport. Localizes to the apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Is expressed in several structures, including cochlea; extraembryonic component; ganglia; and genitourinary system. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6); INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CHAK2; channel kinase 2; melastatin-related TRP cation channel 6; putative cation channel subfamily M member 6; transient receptor potential cation channel 6/channel-kinase 2; transient receptor potential cation channel subfamily M member 6; TRPM6/CHAK2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1918,749,983 - 18,892,511 (+)Ensembl
GRCm381918,730,177 - 18,892,521 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371918,824,473 - 18,967,001 (+)NCBIGRCm37mm9NCBIm37
MGSCv361918,817,002 - 18,959,534 (+)NCBImm8
Celera1919,438,745 - 19,578,144 (+)NCBICelera
Cytogenetic Map19 BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trpm6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320559
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.