Hlcs (holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)) - Rat Genome Database

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Gene: Hlcs (holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)) Mus musculus
Analyze
Symbol: Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Ensembl:holocarboxylase synthetase (biotin-)
RGD ID: 1320490
MGI Page MGI
Description: Enables biotin-protein ligase activity. Involved in biotin metabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 410I21.; 410I21.SP6; biotin apo-protein ligase; biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase; biotin--protein ligase; D16Jhu34
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391693,930,054 - 94,116,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1693,929,741 - 94,114,430 (-)EnsemblGRCm39 Ensembl
GRCm381694,129,306 - 94,315,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,128,882 - 94,313,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,350,912 - 94,509,463 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,239,207 - 94,396,654 (-)NCBIMGSCv36mm8
Celera1695,215,800 - 95,374,528 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
2,3,4,5-tetrachlorophenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-hydroxybenzoic acid  (ISO)
4-hydroxybenzoic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
citric acid  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyanidin cation  (ISO)
ellagic acid  (ISO)
epoxiconazole  (EXP)
ferulic acid  (ISO)
flutamide  (ISO)
folic acid  (EXP)
FR900359  (ISO)
fumaric acid  (ISO)
gallic acid  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
Monobutylphthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nefazodone  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
trans-caffeic acid  (ISO)
trans-piceid  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Clinical findings and biochemical and molecular analysis of four patients with holocarboxylase synthetase deficiency. Morrone A, etal., Am J Med Genet 2002 Jul 22;111(1):10-8.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Human chromosome 21 gene expression atlas in the mouse. Reymond A, etal., Nature 2002 Dec 5;420(6915):582-6.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3493488   PMID:9186515   PMID:9750193   PMID:10337614   PMID:10349636   PMID:10704284   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11374901   PMID:12466851   PMID:12477932  
PMID:12520002   PMID:14610273   PMID:14651853   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:21873635   PMID:32325033   PMID:32376682  
PMID:35385533  


Genomics

Comparative Map Data
Hlcs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391693,930,054 - 94,116,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1693,929,741 - 94,114,430 (-)EnsemblGRCm39 Ensembl
GRCm381694,129,306 - 94,315,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,128,882 - 94,313,571 (-)EnsemblGRCm38mm10GRCm38
MGSCv371694,350,912 - 94,509,463 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361694,239,207 - 94,396,654 (-)NCBIMGSCv36mm8
Celera1695,215,800 - 95,374,528 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.12NCBI
HLCS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382136,748,625 - 36,990,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2136,748,626 - 36,990,236 (-)EnsemblGRCh38hg38GRCh38
GRCh372138,120,926 - 38,362,511 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,045,059 - 37,284,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 342137,045,058 - 37,284,373NCBI
Celera2123,321,570 - 23,560,921 (-)NCBICelera
Cytogenetic Map21q22.13ENTREZGENE
HuRef2123,599,006 - 23,838,349 (-)NCBIHuRef
CHM1_12137,684,363 - 37,923,921 (-)NCBICHM1_1
T2T-CHM13v2.02135,130,819 - 35,372,426 (-)NCBIT2T-CHM13v2.0
Hlcs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81146,925,491 - 47,123,111 (-)NCBIGRCr8
mRatBN7.21133,455,806 - 33,635,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,455,809 - 33,624,222 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01134,357,372 - 34,537,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,352,287 - 34,526,931 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01137,944,545 - 38,122,589 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,382,010 - 34,539,032 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1134,813,786 - 34,994,033 (+)NCBICelera
Cytogenetic Map11q11NCBI
Hlcs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540735,873,826 - 36,074,868 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540735,870,820 - 36,062,066 (-)NCBIChiLan1.0ChiLan1.0
HLCS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22232,865,592 - 33,102,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12127,723,219 - 27,962,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,112,477 - 23,352,121 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12136,467,690 - 36,710,981 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2136,470,872 - 36,655,688 (-)Ensemblpanpan1.1panPan2
HLCS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13131,934,796 - 32,159,866 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3131,937,087 - 32,150,861 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3130,996,015 - 31,222,017 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03131,237,740 - 31,464,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3131,239,237 - 31,441,170 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,106,054 - 31,331,974 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,119,760 - 31,344,999 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03131,609,253 - 31,835,500 (-)NCBIUU_Cfam_GSD_1.0
Hlcs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497131,491,532 - 31,641,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,827,299 - 5,975,439 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,827,213 - 5,976,457 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HLCS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13200,405,064 - 200,607,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113200,406,395 - 200,618,967 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213210,481,824 - 210,683,009 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HLCS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1280,729,064 - 80,973,188 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl280,732,210 - 80,954,071 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660548,571,834 - 8,815,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hlcs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474526,675,837 - 26,847,415 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474526,662,927 - 26,850,236 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hlcs
6845 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1482
Count of miRNA genes:513
Interacting mature miRNAs:581
Transcripts:ENSMUST00000099512, ENSMUST00000163193
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166860072298008968Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166925448298008968Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166907613298008968Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166912761198008968Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167038025298008968Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166912761198008968Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166912761198008968Mouse

Markers in Region
G67818  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,131,823 - 94,132,172UniSTSGRCm38
MGSCv371694,353,429 - 94,353,778UniSTSGRCm37
Celera1695,218,317 - 95,218,666UniSTS
Cytogenetic Map16C4UniSTS
cM Map1610.05UniSTS
G67819  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,270,637 - 94,270,782UniSTSGRCm38
MGSCv371694,492,244 - 94,492,389UniSTSGRCm37
Celera1695,357,310 - 95,357,455UniSTS
Cytogenetic Map16C4UniSTS
cM Map1610.32UniSTS
Hlcs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,267,792 - 94,267,987UniSTSGRCm38
MGSCv371694,489,399 - 94,489,594UniSTSGRCm37
Celera1695,354,461 - 95,354,656UniSTS
Cytogenetic Map16C4UniSTS
cM Map1667.8UniSTS
D11Bhm20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map12D1UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map13D2UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map16C4UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map7B1-B2UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map19BUniSTS
cM Map1144.15UniSTS
Hlcs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381694,129,700 - 94,130,038UniSTSGRCm38
MGSCv371694,351,306 - 94,351,644UniSTSGRCm37
Celera1695,216,194 - 95,216,532UniSTS
Cytogenetic Map16C4UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006522856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030248921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB066227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC173208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK158212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP003155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT573086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  G67818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000099512   ⟹   ENSMUSP00000097112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,930,165 - 94,088,715 (-)Ensembl
GRCm38.p6 Ensembl1694,129,306 - 94,287,856 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163193   ⟹   ENSMUSP00000130981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,929,743 - 94,114,422 (-)Ensembl
GRCm38.p6 Ensembl1694,128,884 - 94,313,563 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,113,076 - 94,114,430 (-)Ensembl
GRCm38.p6 Ensembl1694,312,217 - 94,313,571 (-)Ensembl
RefSeq Acc Id: ENSMUST00000226776
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1694,030,428 - 94,091,129 (-)Ensembl
GRCm38.p6 Ensembl1694,229,569 - 94,290,270 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227141   ⟹   ENSMUSP00000153773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,931,271 - 94,091,145 (-)Ensembl
GRCm38.p6 Ensembl1694,130,412 - 94,290,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,932,798 - 94,006,493 (-)Ensembl
GRCm38.p6 Ensembl1694,131,939 - 94,205,634 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,933,862 - 93,975,859 (-)Ensembl
GRCm38.p6 Ensembl1694,133,003 - 94,175,000 (-)Ensembl
RefSeq Acc Id: ENSMUST00000227698   ⟹   ENSMUSP00000154056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,935,526 - 94,023,976 (-)Ensembl
GRCm38.p6 Ensembl1694,134,667 - 94,223,117 (-)Ensembl
RefSeq Acc Id: ENSMUST00000228910   ⟹   ENSMUSP00000154157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1693,929,741 - 94,046,944 (-)Ensembl
GRCm38.p6 Ensembl1694,128,882 - 94,246,085 (-)Ensembl
RefSeq Acc Id: NM_001360045   ⟹   NP_001346974
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,054 - 94,091,138 (-)NCBI
GRCm381694,129,306 - 94,290,291 (-)NCBI
Sequence:
RefSeq Acc Id: NM_139145   ⟹   NP_631884
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,054 - 94,114,422 (-)NCBI
GRCm381694,129,306 - 94,313,563 (-)NCBI
MGSCv371694,350,912 - 94,509,463 (-)RGD
Celera1695,215,800 - 95,374,528 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006522852   ⟹   XP_006522915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,165 - 94,116,098 (-)NCBI
GRCm381694,129,746 - 94,315,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006522853   ⟹   XP_006522916
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,973,567 - 94,093,380 (-)NCBI
GRCm381694,172,707 - 94,290,963 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006522854   ⟹   XP_006522917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,011,541 - 94,093,378 (-)NCBI
GRCm381694,210,682 - 94,290,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006522855   ⟹   XP_006522918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,165 - 94,104,411 (-)NCBI
GRCm381694,129,746 - 94,303,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006522856   ⟹   XP_006522919
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,054 - 94,103,912 (-)NCBI
GRCm381694,129,746 - 94,303,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248919   ⟹   XP_030104779
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,054 - 94,104,616 (-)NCBI
GRCm381694,129,306 - 94,303,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248920   ⟹   XP_030104780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,165 - 94,114,451 (-)NCBI
GRCm381694,129,746 - 94,313,592 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030248921   ⟹   XP_030104781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391694,011,541 - 94,116,098 (-)NCBI
GRCm381694,210,682 - 94,315,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036159737   ⟹   XP_036015630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391693,930,165 - 94,075,739 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_631884   ⟸   NM_139145
- Peptide Label: isoform 2
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522915   ⟸   XM_006522852
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006522919   ⟸   XM_006522856
- Peptide Label: isoform X4
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522918   ⟸   XM_006522855
- Peptide Label: isoform X4
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006522916   ⟸   XM_006522853
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006522917   ⟸   XM_006522854
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030104779   ⟸   XM_030248919
- Peptide Label: isoform X4
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001346974   ⟸   NM_001360045
- Peptide Label: isoform 1
- UniProtKB: A0A2I3BPG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030104780   ⟸   XM_030248920
- Peptide Label: isoform X4
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030104781   ⟸   XM_030248921
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000097112   ⟸   ENSMUST00000099512
RefSeq Acc Id: ENSMUSP00000130981   ⟸   ENSMUST00000163193
RefSeq Acc Id: ENSMUSP00000154056   ⟸   ENSMUST00000227698
RefSeq Acc Id: ENSMUSP00000153773   ⟸   ENSMUST00000227141
RefSeq Acc Id: ENSMUSP00000154157   ⟸   ENSMUST00000228910
RefSeq Acc Id: XP_036015630   ⟸   XM_036159737
- Peptide Label: isoform X4
- UniProtKB: Q920N2 (UniProtKB/Swiss-Prot),   Q3TZ03 (UniProtKB/TrEMBL)
Protein Domains
BPL/LPL catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920N2-F1-model_v2 AlphaFold Q920N2 1-722 view protein structure

Promoters
RGD ID:13674516
Promoter ID:EPDNEW_M21407
Type:multiple initiation site
Name:Hlcs_1
Description:Mus musculus holocarboxylase synthetase (biotin- ligase) , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381694,290,279 - 94,290,339EPDNEW
RGD ID:6827125
Promoter ID:MM_KWN:21799
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:UC008AAH.1,   UC008AAI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361694,511,589 - 94,512,089 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894646 AgrOrtholog
Ensembl Genes ENSMUSG00000040820 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000099512.3 UniProtKB/Swiss-Prot
  ENSMUST00000163193 ENTREZGENE
  ENSMUST00000163193.9 UniProtKB/Swiss-Prot
  ENSMUST00000227141 ENTREZGENE
  ENSMUST00000227141.2 UniProtKB/TrEMBL
  ENSMUST00000227698.2 UniProtKB/TrEMBL
  ENSMUST00000228910.2 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_CoA_COase_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPL_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPL_LPL_catalytic UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110948 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:894646 ENTREZGENE
NCBI Gene 110948 ENTREZGENE
PANTHER BIOTIN PROTEIN LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTIN--PROTEIN LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BPL_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BPL_LplA_LipB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hlcs PhenoGen
PROSITE BPL_LPL_CATALYTIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2I3BQG1_MOUSE UniProtKB/TrEMBL
  BPL1_MOUSE UniProtKB/Swiss-Prot
  Q3TG10_MOUSE UniProtKB/TrEMBL
  Q3TZ03 ENTREZGENE, UniProtKB/TrEMBL
  Q920N2 ENTREZGENE