Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HLCS (holocarboxylase synthetase) Homo sapiens
Symbol: HLCS
Name: holocarboxylase synthetase
RGD ID: 1320489
Description: Exhibits biotin binding activity; biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; and enzyme binding activity. Involved in histone biotinylation and response to biotin. Localizes to chromatin; cytosol; and nuclear periphery. Implicated in holocarboxylase synthetase deficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: biotin apo-protein ligase; biotin--[acetyl-CoA-carboxylase] ligase; biotin--[methylcrotonoyl-CoA-carboxylase] ligase; biotin--[methylmalonyl-CoA-carboxytransferase] ligase; biotin--protein ligase; HCS; holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
Mus musculus (house mouse) : Hlcs (holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Hlcs (holocarboxylase synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hlcs (holocarboxylase synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : HLCS (holocarboxylase synthetase)
Canis lupus familiaris (dog) : HLCS (holocarboxylase synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hlcs (holocarboxylase synthetase)
Sus scrofa (pig) : HLCS (holocarboxylase synthetase)
Chlorocebus sabaeus (African green monkey) : HLCS (holocarboxylase synthetase)
Heterocephalus glaber (naked mole-rat) : Hlcs (holocarboxylase synthetase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2136,748,626 - 36,990,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2136,750,888 - 36,990,236 (-)EnsemblGRCh38hg38GRCh38
GRCh382136,748,625 - 36,990,255 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372138,123,189 - 38,362,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,045,059 - 37,284,373 (-)NCBINCBI36hg18NCBI36
Build 342137,045,058 - 37,284,373NCBI
Celera2123,321,570 - 23,560,921 (-)NCBI
Cytogenetic Map21q22.13ENTREZGENE
HuRef2123,599,006 - 23,838,349 (-)NCBIHuRef
CHM1_12137,684,363 - 37,923,921 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HLCS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320489
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.