Hoxb2 (homeobox B2) - Rat Genome Database

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Gene: Hoxb2 (homeobox B2) Mus musculus
Analyze
Symbol: Hoxb2
Name: homeobox B2
RGD ID: 1320420
MGI Page MGI
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system development; embryonic skeletal system morphogenesis; and regionalization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; future hindbrain; lung; metanephros; and nervous system. Orthologous to human HOXB2 (homeobox B2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI894218; homeo box B2; homeobox protein Hox-2.8; homeobox protein Hox-B2; Hox-2.; Hox-2.8; Hoxbe; Hoxbes2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,242,458 - 96,244,846 (+)NCBIGRCm39mm39
GRCm39 Ensembl1196,241,351 - 96,244,838 (+)Ensembl
GRCm381196,351,632 - 96,354,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,350,525 - 96,354,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,212,946 - 96,215,330 (+)NCBIGRCm37mm9NCBIm37
MGSCv361196,168,891 - 96,170,106 (+)NCBImm8
Celera11106,002,498 - 106,004,882 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. MGD data from the GO Consortium
2. MGD IEA
3. RGD automated import pipeline
4. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1358459   PMID:1363087   PMID:1582411   PMID:1682814   PMID:1683707   PMID:1685117   PMID:1688181   PMID:1972280   PMID:2571936   PMID:7903221   PMID:7903600   PMID:7903601  
PMID:7925021   PMID:7925028   PMID:8019912   PMID:8056766   PMID:8093858   PMID:8100767   PMID:8102800   PMID:8105001   PMID:8224839   PMID:8314004   PMID:8703472   PMID:8895582  
PMID:8898234   PMID:9012503   PMID:9053316   PMID:9242495   PMID:9806922   PMID:10230789   PMID:10357893   PMID:10373562   PMID:10529420   PMID:10662633   PMID:10835630   PMID:10885747  
PMID:11044609   PMID:11044623   PMID:11518511   PMID:11532923   PMID:12242306   PMID:12385756   PMID:12466851   PMID:12477932   PMID:12514106   PMID:12651891   PMID:12753872   PMID:14522873  
PMID:15042701   PMID:15367676   PMID:15618518   PMID:16079151   PMID:16458891   PMID:16467359   PMID:17065603   PMID:17676642   PMID:18304314   PMID:18547144   PMID:18799693   PMID:19168678  
PMID:19204410   PMID:19922872   PMID:19933700   PMID:20417598   PMID:20932939   PMID:21320481   PMID:21554866   PMID:21672623   PMID:21677750   PMID:21873635   PMID:21982646   PMID:22701719  
PMID:23197710   PMID:23408898   PMID:24525295   PMID:24952961   PMID:28052248   PMID:28188179   PMID:29031500   PMID:32479258  


Genomics

Comparative Map Data
Hoxb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,242,458 - 96,244,846 (+)NCBIGRCm39mm39
GRCm39 Ensembl1196,241,351 - 96,244,838 (+)Ensembl
GRCm381196,351,632 - 96,354,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,350,525 - 96,354,012 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,212,946 - 96,215,330 (+)NCBIGRCm37mm9NCBIm37
MGSCv361196,168,891 - 96,170,106 (+)NCBImm8
Celera11106,002,498 - 106,004,882 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.85NCBI
HOXB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1748,540,894 - 48,545,109 (-)EnsemblGRCh38hg38GRCh38
GRCh381748,542,655 - 48,545,109 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371746,620,017 - 46,622,471 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,975,016 - 43,977,392 (-)NCBINCBI36hg18NCBI36
Build 341743,975,019 - 43,977,391NCBI
Celera1743,074,158 - 43,076,535 (-)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1741,989,338 - 41,991,636 (-)NCBIHuRef
CHM1_11746,685,958 - 46,688,334 (-)NCBICHM1_1
Hoxb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21081,317,927 - 81,320,223 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1084,200,880 - 84,202,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01084,200,859 - 84,203,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01084,003,524 - 84,005,718 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,085,425 - 85,087,617 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11085,099,760 - 85,101,981 (+)NCBI
Celera1080,084,076 - 80,086,261 (+)NCBICelera
Cytogenetic Map10q26NCBI
Hoxb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,694,868 - 12,697,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,693,764 - 12,697,825 (+)NCBIChiLan1.0ChiLan1.0
HOXB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1179,176,313 - 9,178,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,176,313 - 9,178,713 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0178,991,652 - 8,994,092 (+)NCBIMhudiblu_PPA_v0panPan3
HOXB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,803,996 - 24,810,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,804,426 - 24,806,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,268,266 - 24,272,531 (-)NCBI
ROS_Cfam_1.0925,598,684 - 25,602,966 (-)NCBI
UMICH_Zoey_3.1924,366,921 - 24,371,179 (-)NCBI
UNSW_CanFamBas_1.0924,627,553 - 24,631,821 (-)NCBI
UU_Cfam_GSD_1.0924,755,685 - 24,759,948 (-)NCBI
Hoxb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,231,250 - 24,233,965 (-)NCBI
SpeTri2.0NW_00493649012,841,286 - 12,843,782 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOXB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,796,533 - 24,799,536 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,796,786 - 24,800,499 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,754,243 - 24,757,824 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HOXB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,955,651 - 68,958,422 (-)NCBI
ChlSab1.1 Ensembl1668,956,061 - 68,957,903 (-)Ensembl
Vero_WHO_p1.0NW_02366607740,010,169 - 40,012,813 (-)NCBI
Hoxb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247955,043,110 - 5,045,414 (-)NCBI

Position Markers
RH130477  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381196,353,611 - 96,353,837UniSTSGRCm38
MGSCv371196,214,925 - 96,215,151UniSTSGRCm37
Celera11106,004,477 - 106,004,703UniSTS
Cytogenetic Map11DUniSTS
cM Map1156.07UniSTS
AI894218  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381196,353,635 - 96,353,739UniSTSGRCm38
MGSCv371196,214,949 - 96,215,053UniSTSGRCm37
Celera11106,004,501 - 106,004,605UniSTS
Cytogenetic Map11DUniSTS
cM Map1156.07UniSTS
Whitehead/MRC_RH111268.1UniSTS
Hoxb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map1159.85UniSTS
Hoxb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301313Pas5a_mpulmonary adenoma susceptibility 5a (mouse)Not determined118907597898974942Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118880876299190771Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187800372103383289Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
14700796Syncq9_msynovial calcification QTL 9 (mouse)119604700097102000Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1181000000102000000Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:550
Count of miRNA genes:297
Interacting mature miRNAs:436
Transcripts:ENSMUST00000100523, ENSMUST00000182030
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000100523   ⟹   ENSMUSP00000098092
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1196,351,631 - 96,354,012 (+)Ensembl
RefSeq Acc Id: ENSMUST00000182030
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1196,350,525 - 96,353,658 (+)Ensembl
RefSeq Acc Id: NM_134032   ⟹   NP_598793
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391196,242,458 - 96,244,842 (+)NCBI
GRCm381196,351,632 - 96,354,016 (+)NCBI
MGSCv371196,212,946 - 96,215,330 (+)RGD
Celera11106,002,498 - 106,004,882 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531932   ⟹   XP_006531995
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391196,243,352 - 96,244,846 (+)NCBI
GRCm381196,352,423 - 96,354,020 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598793   ⟸   NM_134032
- UniProtKB: P0C1T1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006531995   ⟸   XM_006531932
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000098092   ⟸   ENSMUST00000100523

Promoters
RGD ID:6821074
Promoter ID:MM_KWN:9407
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:ENSMUST00000100523
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361196,213,134 - 96,213,634 (+)MPROMDB
RGD ID:8676344
Promoter ID:EPDNEW_M16203
Type:initiation region
Name:Hoxb2_1
Description:Mus musculus homeobox B2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381196,351,632 - 96,351,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96183 AgrOrtholog
Ensembl Genes ENSMUSG00000075588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000098092 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000100523 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_Antennapedia_CS UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:103889 UniProtKB/Swiss-Prot
MGD MGI:96183 ENTREZGENE
NCBI Gene 103889 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Hoxb2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE ANTENNAPEDIA UniProtKB/Swiss-Prot
  HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt HXB2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2A739 UniProtKB/Swiss-Prot
  B9EHW9 UniProtKB/Swiss-Prot