Lrrtm2 (leucine rich repeat transmembrane neuronal 2) - Rat Genome Database
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Gene: Lrrtm2 (leucine rich repeat transmembrane neuronal 2) Mus musculus
Analyze
Symbol: Lrrtm2
Name: leucine rich repeat transmembrane neuronal 2
RGD ID: 1320356
MGI Page MGI
Description: Predicted to have neurexin family protein binding activity. Involved in several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Predicted to localize to several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and integral component of postsynaptic density membrane. Is expressed in neural tube and neural tube lateral wall. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; clobetasol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI851755; BB129880; C630011A14Rik; leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat transmembrane neuronal protein 2; mKIAA0416
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,342,056 - 35,348,077 (-)NCBIGRCm39mm39
GRCm39 Ensembl1835,342,056 - 35,348,077 (-)Ensembl
GRCm381835,209,003 - 35,215,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,209,003 - 35,215,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,368,657 - 35,374,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361835,336,885 - 35,340,892 (-)NCBImm8
Celera1835,664,662 - 35,670,684 (-)NCBICelera
Cytogenetic Map18B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12676565   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16860615   PMID:21267068   PMID:21788371  
PMID:21873635   PMID:22991445   PMID:23931994   PMID:24192035   PMID:24613359   PMID:25527504   PMID:26785044   PMID:26979420   PMID:29784826   PMID:30262834   PMID:32325033  


Genomics

Comparative Map Data
Lrrtm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,342,056 - 35,348,077 (-)NCBIGRCm39mm39
GRCm39 Ensembl1835,342,056 - 35,348,077 (-)Ensembl
GRCm381835,209,003 - 35,215,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,209,003 - 35,215,024 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,368,657 - 35,374,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361835,336,885 - 35,340,892 (-)NCBImm8
Celera1835,664,662 - 35,670,684 (-)NCBICelera
Cytogenetic Map18B1NCBI
LRRTM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5138,868,921 - 138,875,368 (-)EnsemblGRCh38hg38GRCh38
GRCh385138,868,921 - 138,875,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375138,204,610 - 138,211,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,232,978 - 138,238,908 (-)NCBINCBI36hg18NCBI36
Build 345138,232,977 - 138,238,908NCBI
Celera5134,326,860 - 134,332,826 (-)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5133,394,868 - 133,400,836 (-)NCBIHuRef
CHM1_15137,637,719 - 137,643,697 (-)NCBICHM1_1
Lrrtm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21826,817,816 - 26,822,864 (-)NCBI
Rnor_6.0 Ensembl1828,012,877 - 28,017,925 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01828,012,877 - 28,017,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01827,722,686 - 27,727,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,722,717 - 27,727,765 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1826,552,974 - 26,558,022 (-)NCBICelera
Cytogenetic Map18p11NCBI
Lrrtm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,636,828 - 1,643,588 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554181,636,906 - 1,643,430 (+)NCBIChiLan1.0ChiLan1.0
LRRTM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15140,373,790 - 140,380,127 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v05134,247,933 - 134,254,188 (-)NCBIMhudiblu_PPA_v0panPan3
LRRTM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11126,392,642 - 26,397,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1126,392,734 - 26,396,223 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1125,159,555 - 25,163,871 (-)NCBI
ROS_Cfam_1.01127,248,202 - 27,252,518 (-)NCBI
UMICH_Zoey_3.11125,955,564 - 25,959,881 (-)NCBI
UNSW_CanFamBas_1.01125,775,869 - 25,782,210 (-)NCBI
UU_Cfam_GSD_1.01126,442,410 - 26,446,727 (-)NCBI
Lrrtm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,637,684 - 153,641,722 (+)NCBI
SpeTri2.0NW_0049365317,968,111 - 7,973,823 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRTM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,803,120 - 140,809,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,803,624 - 140,810,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22146,698,365 - 146,704,568 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRTM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12341,534,757 - 41,540,372 (-)NCBI
ChlSab1.1 Ensembl2341,533,973 - 41,539,915 (-)Ensembl
Lrrtm2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474331,648,543 - 31,651,772 (-)NCBI

Position Markers
AI851755  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381835,210,089 - 35,210,192UniSTSGRCm38
MGSCv371835,369,743 - 35,369,846UniSTSGRCm37
Celera1835,665,748 - 35,665,851UniSTS
Cytogenetic Map18B1UniSTS
cM Map1811.0UniSTS
BB129880  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381835,212,052 - 35,212,142UniSTSGRCm38
MGSCv371835,371,706 - 35,371,796UniSTSGRCm37
Celera1835,667,712 - 35,667,802UniSTS
Cytogenetic Map18B1UniSTS
cM Map1811.0UniSTS
Whitehead/MRC_RH18459.8UniSTS
Lrrtm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371835,372,794 - 35,373,430UniSTSGRCm37
MGSCv371835,371,779 - 35,372,388UniSTSGRCm37
Celera1835,667,785 - 35,668,394UniSTS
Celera1835,668,800 - 35,669,436UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map18B1UniSTS
cM Map18 UniSTS
cM Map1811.0UniSTS
cM Map1811.0UniSTS
Lrrtm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381835,212,125 - 35,212,734UniSTSGRCm38
MGSCv371835,371,779 - 35,372,388UniSTSGRCm37
Celera1835,667,785 - 35,668,394UniSTS
Cytogenetic Map18B1UniSTS
cM Map18 UniSTS
Lrrtm2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381835,213,140 - 35,213,776UniSTSGRCm38
MGSCv371835,372,794 - 35,373,430UniSTSGRCm37
Celera1835,668,800 - 35,669,436UniSTS
Cytogenetic Map18B1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060800000Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961139571Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18795390741954049Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181350407347504073Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181389696666965891Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181606658750066723Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181800665152006806Mouse
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181888582152885939Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181888582152885939Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182082063757457636Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182108452755084674Mouse
1301950Otx2m1_morthodenticle homolog 2 (Drosophila) modifier 1 (mouse)Not determined182143562536054687Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182248686156487074Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182248686156487074Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182248686156487074Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182248686156487074Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182248686156487074Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182398250757982677Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182592381059923810Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182710806258694005Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182710806258694005Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182710806258694005Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182797631361976451Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2799753761997672Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182953484763534993Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183010000064100000Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183185541365855562Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183295797666958154Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1386
Count of miRNA genes:607
Interacting mature miRNAs:786
Transcripts:ENSMUST00000091636
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000091636   ⟹   ENSMUSP00000089225
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1835,209,003 - 35,215,024 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236530
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1835,212,137 - 35,215,008 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236680   ⟹   ENSMUSP00000157843
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1835,212,311 - 35,215,024 (-)Ensembl
RefSeq Acc Id: NM_178005   ⟹   NP_821072
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391835,342,056 - 35,348,077 (-)NCBI
GRCm381835,209,003 - 35,215,024 (-)ENTREZGENE
MGSCv371835,368,657 - 35,374,678 (-)RGD
Celera1835,664,662 - 35,670,684 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_821072   ⟸   NM_178005
- Peptide Label: precursor
- UniProtKB: Q8BGA3 (UniProtKB/Swiss-Prot),   Q8C8L1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000089225   ⟸   ENSMUST00000091636
RefSeq Acc Id: ENSMUSP00000157843   ⟸   ENSMUST00000236680
Protein Domains
LRRCT   LRRNT

Promoters
RGD ID:13677402
Promoter ID:EPDNEW_M22851
Type:initiation region
Name:Lrrtm2_1
Description:Mus musculus leucine rich repeat transmembrane neuronal 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381835,215,018 - 35,215,078EPDNEW
RGD ID:6829345
Promoter ID:MM_KWN:24916
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   MEF_B6
Transcripts:ENSMUST00000091636,   NM_178005
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361835,373,216 - 35,375,567 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2389174 AgrOrtholog
Ensembl Genes ENSMUSG00000048885
  ENSMUSG00000071862 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000089225 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157843 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000091636 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000236680 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:107065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2389174 ENTREZGENE
NCBI Gene 107065 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrtm2 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9W9_MOUSE UniProtKB/TrEMBL
  LRRT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C8L1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q80U08 UniProtKB/Swiss-Prot