Sh2d7 (SH2 domain containing 7) - Rat Genome Database

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Gene: Sh2d7 (SH2 domain containing 7) Mus musculus
Analyze
Symbol: Sh2d7
Name: SH2 domain containing 7
RGD ID: 1320320
MGI Page MGI
Description: Predicted to be active in cytoplasm. Is expressed in intestine; liver; male reproductive gland or organ; stomach; and thymus. Orthologous to human SH2D7 (SH2 domain containing 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933412E14Rik; RP23-259G10.2; SH2 domain-containing protein 7
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,441,407 - 54,452,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,441,430 - 54,452,304 (+)EnsemblGRCm39 Ensembl
GRCm38954,534,123 - 54,545,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,534,146 - 54,545,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,386,791 - 54,392,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,337,121 - 54,343,157 (+)NCBIMGSCv36mm8
Celera951,781,890 - 51,787,925 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:24194600  
PMID:29254152  


Genomics

Comparative Map Data
Sh2d7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,441,407 - 54,452,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,441,430 - 54,452,304 (+)EnsemblGRCm39 Ensembl
GRCm38954,534,123 - 54,545,030 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,534,146 - 54,545,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv37954,386,791 - 54,392,827 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36954,337,121 - 54,343,157 (+)NCBIMGSCv36mm8
Celera951,781,890 - 51,787,925 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.7NCBI
SH2D7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,090,122 - 78,104,362 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,077,808 - 78,104,370 (+)EnsemblGRCh38hg38GRCh38
GRCh371578,384,903 - 78,396,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,171,982 - 76,183,448 (+)NCBINCBI36Build 36hg18NCBI36
Celera1555,320,939 - 55,332,405 (+)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,142,486 - 55,153,951 (+)NCBIHuRef
CHM1_11578,502,865 - 78,514,331 (+)NCBICHM1_1
T2T-CHM13v2.01575,952,673 - 75,966,918 (+)NCBIT2T-CHM13v2.0
Sh2d7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8863,813,054 - 63,826,714 (+)NCBIGRCr8
mRatBN7.2854,918,399 - 54,930,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl854,918,406 - 54,929,726 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0859,110,859 - 59,122,974 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,111,271 - 59,121,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0857,691,617 - 57,702,057 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4858,055,341 - 58,092,402 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1858,074,394 - 58,110,615 (+)NCBI
Celera854,407,901 - 54,418,811 (+)NCBICelera
Cytogenetic Map8q24NCBI
Sh2d7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450650,339 - 660,567 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955450650,339 - 660,567 (+)NCBIChiLan1.0ChiLan1.0
SH2D7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,305,823 - 67,318,647 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,471,348 - 71,484,162 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,021,217 - 57,031,176 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11575,987,008 - 75,996,156 (+)NCBIpanpan1.1PanPan1.1panPan2
SH2D7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha360,959,502 - 60,967,693 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0358,735,956 - 58,744,156 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1358,232,494 - 58,240,679 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,440,650 - 58,448,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,789,887 - 58,797,827 (+)NCBIUU_Cfam_GSD_1.0
Sh2d7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640119,034,179 - 119,041,634 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647136,880,275 - 36,885,096 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2D7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,813,512 - 47,824,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1747,812,996 - 47,824,926 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,364,515 - 53,376,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH2D7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,247,866 - 5,260,659 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,249,265 - 5,260,145 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048136,542,713 - 136,551,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2d7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248942,704,918 - 2,711,771 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh2d7
304 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:659
Count of miRNA genes:438
Interacting mature miRNAs:469
Transcripts:ENSMUST00000060242, ENSMUST00000118413
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94348071477480860Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94348071477480860Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94442817478428262Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4659767165831177Mouse
4141754Fecq4_mfecundity QTL 4 (mouse)Not determined94754302457805204Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94883105682831177Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94883105682831177Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94942029863239852Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94942029867151448Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49452421101406120Mouse
14746993Manh66_mmandible shape 66 (mouse)94981404883814048Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95015132084151448Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95203447899792481Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95242609868556008Mouse

Markers in Region
AI449053  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38954,545,054 - 54,545,159UniSTSGRCm38
MGSCv37954,392,861 - 54,392,966UniSTSGRCm37
Celera951,787,959 - 51,788,064UniSTS
Cytogenetic Map9A5.3UniSTS
Whitehead/MRC_RH9542.48UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000060242   ⟹   ENSMUSP00000053690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,446,268 - 54,452,304 (+)Ensembl
GRCm38.p6 Ensembl954,538,984 - 54,545,020 (+)Ensembl
RefSeq Acc Id: ENSMUST00000118413   ⟹   ENSMUSP00000113298
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,441,430 - 54,452,304 (+)Ensembl
GRCm38.p6 Ensembl954,534,146 - 54,545,020 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl954,446,272 - 54,450,938 (+)Ensembl
GRCm38.p6 Ensembl954,538,988 - 54,543,654 (+)Ensembl
RefSeq Acc Id: NM_173778   ⟹   NP_776139
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,441,407 - 54,452,303 (+)NCBI
GRCm38954,534,123 - 54,545,019 (+)NCBI
MGSCv37954,386,791 - 54,392,827 (+)RGD
Celera951,781,890 - 51,787,925 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511158   ⟹   XP_006511221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39954,446,272 - 54,452,314 (+)NCBI
GRCm38954,538,988 - 54,545,030 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_776139   ⟸   NM_173778
- UniProtKB: Q8BI17 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511221   ⟸   XM_006511158
- Peptide Label: isoform X1
- UniProtKB: Q8BI17 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113298   ⟸   ENSMUST00000118413
RefSeq Acc Id: ENSMUSP00000053690   ⟸   ENSMUST00000060242
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BI17-F1-model_v2 AlphaFold Q8BI17 1-458 view protein structure

Promoters
RGD ID:6843992
Promoter ID:MM_KWN:57437
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4
Transcripts:NM_173778,   UC009PRE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36954,386,721 - 54,387,221 (+)MPROMDB
RGD ID:8669636
Promoter ID:EPDNEW_M12849
Type:multiple initiation site
Name:Sh2d7_1
Description:Mus musculus SH2 domain containing 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38954,538,921 - 54,538,981EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2441692 AgrOrtholog
Ensembl Genes ENSMUSG00000046460 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000060242 ENTREZGENE
  ENSMUST00000060242.12 UniProtKB/Swiss-Prot
  ENSMUST00000118413 ENTREZGENE
  ENSMUST00000118413.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH2D7_SH2 UniProtKB/Swiss-Prot
KEGG Report mmu:244885 UniProtKB/Swiss-Prot
MGD MGI:2441692 ENTREZGENE
NCBI Gene 244885 ENTREZGENE
PANTHER SH2 DOMAIN-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot
  T CELL-SPECIFIC ADAPTER PROTEIN TSAD UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
PhenoGen Sh2d7 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
UniProt Q8BI17 ENTREZGENE, UniProtKB/Swiss-Prot