Symbol:
RPL27A
Name:
ribosomal protein L27a
Description:
Exhibits RNA binding activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and translational initiation. Localizes to the cytosol and endoplasmic reticulum.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
60S ribosomal protein L27a; FLJ43464; L27A; large ribosomal subunit protein uL15; MGC10850; MGC17878; MGC87238
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Rpl27a (ribosomal protein L27A) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
Rpl27a (ribosomal protein L27a) HGNC
EggNOG, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Rpl27a (ribosomal protein L27a) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
RPL27A (ribosomal protein L27a) NCBI
Ortholog
Canis lupus familiaris (dog):
RPL27A (ribosomal protein L27a) HGNC
HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rpl27a (ribosomal protein L27a) NCBI
Ortholog
Sus scrofa (pig):
RPL27A (ribosomal protein L27a) HGNC
EggNOG, NCBI, OMA, OrthoDB, Treefam
Other homologs 2
Rattus norvegicus (Norway rat):
RGD1560633 (similar to ribosomal protein L27a) HGNC
Ensembl, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
RGD1562402 (similar to 60S ribosomal protein L27a) HGNC
Inparanoid, OMA, Panther
Rattus norvegicus (Norway rat):
LOC108351703 (60S ribosomal protein L27a-like) HGNC
Ensembl, OMA, Panther
Rattus norvegicus (Norway rat):
RGD1559972 (similar to ribosomal protein L27a) HGNC
Panther
Rattus norvegicus (Norway rat):
RGD1565415 (similar to ribosomal protein L27a) HGNC
Panther
Canis lupus familiaris (dog):
LOC102157274 (60S ribosomal protein L27a-like) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Rpl27a (ribosomal protein L27a)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Mus musculus (house mouse):
Rpl27a (ribosomal protein L27A)
Alliance
DIOPT (HGNC, OMA, OrthoFinder, PANTHER, TreeFam)
Rattus norvegicus (Norway rat):
RGD1560633 (similar to ribosomal protein L27a)
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Mus musculus (house mouse):
Gm7536 (predicted gene 7536)
Alliance
DIOPT (Hieranoid, InParanoid, OMA, OrthoInspector, Roundup, TreeFam)
Danio rerio (zebrafish):
rpl27a (ribosomal protein L27a)
Alliance
DIOPT (Hieranoid, OrthoFinder, PhylomeDB, ZFIN)
Caenorhabditis elegans (roundworm):
Y37E3.8
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Saccharomyces cerevisiae (baker's yeast):
RPL28
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
RpL27A
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Related Pseudogenes:
RPL27AP
RPL27AP2
RPL27AP3
RPL27AP4
RPL27AP5
RPL27AP6
RPL27AP7
RPL27AP8
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 11 8,682,792 - 8,689,872 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 11 8,703,995 - 8,711,419 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 11 8,660,571 - 8,667,995 (+) NCBI NCBI36 hg18 NCBI36 Build 34 11 8,660,914 - 8,663,969 NCBI Celera 11 8,821,627 - 8,829,051 (+) NCBI Cytogenetic Map 11 p15.4 NCBI HuRef 11 8,371,987 - 8,379,412 (+) NCBI HuRef CHM1_1 11 8,702,911 - 8,710,345 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RPL27A mRNA CTD PMID:22079256 (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of RPL27A protein CTD PMID:31195006 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of RPL27A mRNA CTD PMID:17374397 17alpha-ethynylestradiol increases expression ISO RGD:1309771 6480464 Ethinyl Estradiol results in increased expression of RPL27A mRNA CTD PMID:17108234 17beta-estradiol multiple interactions EXP 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RPL27A mRNA CTD PMID:17404688 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1320287 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPL27A mRNA CTD PMID:16214954 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RPL27A mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320287 6480464 Tetrachlorodibenzodioxin affects the expression of RPL27A mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1320287 6480464 Tetrachlorodibenzodioxin results in decreased expression of RPL27A mRNA CTD PMID:19465110 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression EXP 6480464 Oxazolone results in increased expression of RPL27A mRNA CTD PMID:17374397 6-propyl-2-thiouracil increases expression ISO RGD:1309771 6480464 Propylthiouracil results in increased expression of RPL27A mRNA CTD PMID:24780913 ammonium chloride affects expression ISO RGD:1309771 6480464 Ammonium Chloride affects the expression of RPL27A mRNA CTD PMID:16483693 Aroclor 1254 increases expression ISO RGD:1320287 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of RPL27A mRNA CTD PMID:23650126 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of RPL27A mRNA CTD PMID:20106945 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of RPL27A mRNA CTD PMID:21632981 benzo[a]pyrene increases expression ISO RGD:1320287 6480464 Benzo(a)pyrene results in increased expression of RPL27A mRNA CTD PMID:19770486 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20018196 benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:19150397 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of RPL27A mRNA CTD PMID:12884408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RPL27A mRNA CTD PMID:22576693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RPL27A mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:1309771 6480464 bisphenol A results in increased expression of RPL27A mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1320287 6480464 bisphenol A results in increased expression of RPL27A mRNA CTD PMID:26063408 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of RPL27A gene CTD PMID:22576693 bromobenzene increases expression ISO RGD:1309771 6480464 bromobenzene results in increased expression of RPL27A mRNA CTD PMID:16036859 caffeine increases expression EXP 6480464 Caffeine results in increased expression of RPL27A protein CTD PMID:31195006 carbon nanotube decreases expression ISO RGD:1320287 6480464 Nanotubes, Carbon analog results in decreased expression of RPL27A mRNA, Nanotubes, Carbon results in decreased expression of RPL27A mRNA CTD PMID:25554681 chloropicrin decreases expression EXP 6480464 chloropicrin results in decreased expression of RPL27A mRNA CTD PMID:26352163 choline multiple interactions ISO RGD:1320287 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPL27A mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:1320287 6480464 chromium hexavalent ion affects the expression of RPL27A mRNA CTD PMID:28472532 chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of RPL27A mRNA CTD PMID:30690063 clofibrate multiple interactions ISO RGD:1320287 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RPL27A mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RPL27A mRNA] CTD PMID:17585979 clofibrate decreases expression ISO RGD:1320287 6480464 Clofibrate results in decreased expression of RPL27A mRNA CTD PMID:17585979 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of RPL27A mRNA CTD PMID:19376846 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of RPL27A mRNA CTD PMID:25562108 , PMID:27989131 cylindrospermopsin increases expression ISO RGD:1320287 6480464 cylindrospermopsin results in increased expression of RPL27A mRNA CTD PMID:20936652 deoxynivalenol decreases expression EXP 6480464 deoxynivalenol results in decreased expression of RPL27A mRNA CTD PMID:24247028 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPL27A mRNA CTD PMID:27188386 enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RPL27A protein CTD PMID:23301498 ethanol multiple interactions ISO RGD:1320287 6480464 Ethanol affects the expression of and affects the splicing of RPL27A mRNA CTD PMID:30319688 eugenol increases expression EXP 6480464 Eugenol results in increased expression of RPL27A mRNA CTD PMID:17374397 folic acid multiple interactions ISO RGD:1320287 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPL27A mRNA CTD PMID:20938992 gentamycin increases expression ISO RGD:1309771 6480464 Gentamicins results in increased expression of RPL27A mRNA CTD PMID:22061828 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of RPL27A mRNA CTD PMID:23410634 isoprenaline decreases expression ISO RGD:1320287 6480464 Isoproterenol results in decreased expression of RPL27A mRNA CTD PMID:20003209 L-methionine multiple interactions ISO RGD:1320287 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RPL27A mRNA CTD PMID:20938992 melphalan increases expression EXP 6480464 Melphalan results in increased expression of RPL27A mRNA CTD PMID:22363485 menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of RPL27A mRNA CTD PMID:23410634 methylseleninic acid decreases expression EXP 6480464 methylselenic acid results in decreased expression of RPL27A mRNA CTD PMID:18548127 miconazole increases expression ISO RGD:1320287 6480464 Miconazole results in increased expression of RPL27A mRNA CTD PMID:27462272 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:1320287 6480464 Ethylnitrosourea results in increased mutagenesis of RPL27A gene CTD PMID:21674502 N-nitrosodiethylamine multiple interactions ISO RGD:1320287 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RPL27A mRNA] CTD PMID:17942915 N-nitrosodiethylamine increases expression ISO RGD:1320287 6480464 Diethylnitrosamine results in increased expression of RPL27A mRNA CTD PMID:17942915 paracetamol multiple interactions ISO RGD:1320287 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of RPL27A mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RPL27A mRNA] CTD PMID:17585979 paracetamol affects expression ISO RGD:1320287 6480464 Acetaminophen affects the expression of RPL27A mRNA CTD PMID:17562736 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of RPL27A protein CTD PMID:26879310 phenobarbital affects expression ISO RGD:1320287 6480464 Phenobarbital affects the expression of RPL27A mRNA CTD PMID:23091169 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of RPL27A mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPL27A mRNA CTD PMID:27188386 PhIP increases expression ISO RGD:1309771 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of RPL27A mRNA CTD PMID:15215175 potassium chromate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RPL27A mRNA CTD PMID:22079256 potassium chromate increases expression EXP 6480464 potassium chromate(VI) results in increased expression of RPL27A mRNA CTD PMID:22079256 , PMID:22714537 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1320287 6480464 Pregnenolone Carbonitrile results in increased expression of RPL27A mRNA CTD PMID:28903501 progesterone multiple interactions EXP 6480464 [Progesterone co-treated with Estradiol] results in decreased expression of RPL27A mRNA CTD PMID:17404688 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of RPL27A mRNA CTD PMID:17404688 quercetin increases expression EXP 6480464 Quercetin results in increased expression of RPL27A mRNA CTD PMID:21632981 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of RPL27A mRNA CTD PMID:29955902 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RPL27A mRNA CTD PMID:27188386 silicon dioxide increases expression EXP 6480464 Silicon Dioxide analog results in increased expression of RPL27A mRNA CTD PMID:25895662 sodium arsenite increases expression ISO RGD:1309771 6480464 sodium arsenite results in increased expression of RPL27A mRNA CTD PMID:19072884 tert-butyl hydroperoxide affects expression EXP 6480464 tert-Butylhydroperoxide affects the expression of RPL27A mRNA CTD PMID:23410634 thapsigargin affects expression EXP 6480464 Thapsigargin affects the expression of RPL27A mRNA CTD PMID:24247028 titanium dioxide decreases expression ISO RGD:1320287 6480464 titanium dioxide results in decreased expression of RPL27A mRNA CTD PMID:27760801 Tributyltin oxide decreases expression EXP 6480464 bis(tri-n-butyltin)oxide results in decreased expression of RPL27A mRNA CTD PMID:24247028 trichloroethene decreases expression ISO RGD:1320287 6480464 Trichloroethylene results in decreased expression of RPL27A mRNA CTD PMID:19448997 tungsten increases expression ISO RGD:1320287 6480464 Tungsten results in increased expression of RPL27A mRNA CTD PMID:30912803 valproic acid affects expression ISO RGD:1320287 6480464 Valproic Acid affects the expression of RPL27A mRNA CTD PMID:17963808 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of RPL27A mRNA CTD PMID:23179753 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of RPL27A mRNA CTD PMID:25979313 
Gene-Chemical Interaction Annotations
