Trim16 (tripartite motif-containing 16) - Rat Genome Database
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Gene: Trim16 (tripartite motif-containing 16) Mus musculus
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Symbol: Trim16
Name: tripartite motif-containing 16
RGD ID: 1320253
MGI Page MGI
Description: Predicted to have DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Predicted to be involved in several processes, including histone acetylation; positive regulation of gene expression; and positive regulation of retinoic acid receptor signaling pathway. Localizes to cytoplasm. Is expressed in genitourinary system. Orthologous to several human genes including TRIM16 (tripartite motif containing 16); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9130006M08Rik; AI482483; E3 ubiquitin-protein ligase TRIM16; EBB; EBBP; estrogen-responsive B box protein; tripartite motif protein 16; tripartite motif-containing protein 16
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,711,034 - 62,733,774 (+)NCBIGRCm39mm39
GRCm381162,820,198 - 62,842,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,820,231 - 62,850,808 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,633,755 - 62,656,450 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,636,448 - 62,659,143 (+)NCBImm8
Celera1169,742,229 - 69,768,302 (+)NCBICelera
Cytogenetic Map11B2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (ISO)
plasma membrane  (ISO)
PML body  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11919186   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15937080   PMID:16141072   PMID:16141073   PMID:18287559   PMID:21267068  
PMID:23341783   PMID:31342168   PMID:32325033  


Genomics

Comparative Map Data
Trim16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,711,034 - 62,733,774 (+)NCBIGRCm39mm39
GRCm381162,820,198 - 62,842,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,820,231 - 62,850,808 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,633,755 - 62,656,450 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,636,448 - 62,659,143 (+)NCBImm8
Celera1169,742,229 - 69,768,302 (+)NCBICelera
Cytogenetic Map11B2NCBI
TRIM16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1715,627,960 - 15,684,311 (-)EnsemblGRCh38hg38GRCh38
GRCh381715,627,966 - 15,684,311 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371715,531,280 - 15,587,625 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371715,531,277 - 15,587,625 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,472,005 - 15,526,918 (-)NCBINCBI36hg18NCBI36
Build 341715,472,005 - 15,526,918NCBI
Cytogenetic Map17p12NCBI
HuRef1715,404,775 - 15,461,210 (-)NCBIHuRef
CHM1_11715,540,352 - 15,595,047 (-)NCBICHM1_1
Trim16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21047,485,982 - 47,509,010 (+)NCBI
Rnor_6.0 Ensembl1049,231,730 - 49,254,621 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01049,231,660 - 49,254,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01049,011,305 - 49,033,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,987,004 - 49,009,696 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11049,000,664 - 49,021,215 (+)NCBI
Celera1046,731,462 - 46,754,204 (+)NCBICelera
Cytogenetic Map10q23NCBI
Trim16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554672,059,777 - 2,085,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554672,059,793 - 2,084,221 (+)NCBIChiLan1.0ChiLan1.0
TRIM16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01735,973,775 - 36,028,767 (+)NCBIMhudiblu_PPA_v0panPan3
TRIM16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl539,148,868 - 39,213,203 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1539,146,505 - 39,167,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Trim16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367242,101,942 - 2,122,747 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11258,926,083 - 58,940,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRIM16
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11614,874,159 - 14,897,958 (-)NCBI
Trim16
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248773,688,635 - 3,713,718 (-)NCBI

Position Markers
47.MMHAP20FRH11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381162,818,659 - 62,818,814UniSTSGRCm38
MGSCv371162,632,161 - 62,632,316UniSTSGRCm37
Celera1169,740,648 - 69,740,803UniSTS
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11832.16UniSTS
AI482483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381162,841,079 - 62,841,172UniSTSGRCm38
MGSCv371162,654,581 - 62,654,674UniSTSGRCm37
Celera1169,763,837 - 69,763,930UniSTS
Cytogenetic Map11B2UniSTS
Whitehead/MRC_RH11829.12UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11330000063000000Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111180000066100000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113111738265117382Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113220975066209867Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5417484463428696Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115419011565213015Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1535
Count of miRNA genes:560
Interacting mature miRNAs:657
Transcripts:ENSMUST00000055006, ENSMUST00000072639, ENSMUST00000108703, ENSMUST00000128623, ENSMUST00000147942
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000055006   ⟹   ENSMUSP00000055542
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,820,231 - 62,842,936 (+)Ensembl
RefSeq Acc Id: ENSMUST00000072639   ⟹   ENSMUSP00000072432
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,820,253 - 62,850,808 (+)Ensembl
RefSeq Acc Id: ENSMUST00000108703   ⟹   ENSMUSP00000104343
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,820,469 - 62,842,936 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,833,800 - 62,841,457 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147942
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1162,820,440 - 62,821,245 (+)Ensembl
RefSeq Acc Id: NM_053169   ⟹   NP_444399
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,711,079 - 62,733,774 (+)NCBI
GRCm381162,820,253 - 62,842,948 (+)NCBI
MGSCv371162,633,755 - 62,656,450 (+)RGD
Celera1169,742,229 - 69,768,302 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006534580   ⟹   XP_006534643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391162,711,034 - 62,733,764 (+)NCBI
GRCm381162,820,198 - 62,842,938 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_444399   ⟸   NM_053169
- UniProtKB: Q99PP9 (UniProtKB/Swiss-Prot),   Q5SVT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006534643   ⟸   XM_006534580
- Peptide Label: isoform X1
- UniProtKB: Q99PP9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000072432   ⟸   ENSMUST00000072639
RefSeq Acc Id: ENSMUSP00000104343   ⟸   ENSMUST00000108703
RefSeq Acc Id: ENSMUSP00000055542   ⟸   ENSMUST00000055006
Protein Domains
B30.2/SPRY

Promoters
RGD ID:6822375
Promoter ID:MM_KWN:7850
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000108704,   OTTMUST00000013084,   OTTMUST00000013086,   UC007JKB.1,   UC007JKC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,633,686 - 62,634,186 (+)MPROMDB
RGD ID:6822381
Promoter ID:MM_KWN:7852
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000036085,   NM_001033669,   UC007JKE.1,   UC007JKG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361162,660,396 - 62,660,896 (+)MPROMDB
RGD ID:8675026
Promoter ID:EPDNEW_M15535
Type:initiation region
Name:Trim16_1
Description:Mus musculus tripartite motif-containing 16 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381162,820,440 - 62,820,500EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2137356 AgrOrtholog
Ensembl Genes ENSMUSG00000047821 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000055542 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000072432 UniProtKB/TrEMBL
  ENSMUSP00000104343 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000055006 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000072639 UniProtKB/TrEMBL
  ENSMUST00000108703 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyrophylin_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:94092 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2137356 ENTREZGENE
NCBI Gene 94092 ENTREZGENE
Pfam PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim16 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q5SVT1_MOUSE UniProtKB/TrEMBL
  Q5SVT2 ENTREZGENE, UniProtKB/TrEMBL
  Q99PP9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D3Z5R5 UniProtKB/TrEMBL
  Q7TPY6 UniProtKB/Swiss-Prot
  Q8C332 UniProtKB/Swiss-Prot
  Q8C6V0 UniProtKB/Swiss-Prot