Lamtor4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4) - Rat Genome Database

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Gene: Lamtor4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4) Mus musculus
Analyze
Symbol: Lamtor4
Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
RGD ID: 1320233
MGI Page MGI
Description: Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Is expressed in brain and retina layer. Orthologous to human LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0910001L09Rik; AV006840; hypothetical protein LOC66096; late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; ragulator complex protein LAMTOR4; UPF0539 protein; UPF0539 protein C7orf59 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,253,744 - 138,257,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,253,744 - 138,257,660 (+)EnsemblGRCm39 Ensembl
GRCm385138,255,482 - 138,259,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,255,482 - 138,259,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,696,710 - 138,700,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,485,519 - 138,489,187 (+)NCBIMGSCv36mm8
Celera5135,238,334 - 135,242,247 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of mTORC1 by amino acids. Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20381137  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22980980   PMID:30595499   PMID:32325033   PMID:32553155  


Genomics

Comparative Map Data
Lamtor4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,253,744 - 138,257,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,253,744 - 138,257,660 (+)EnsemblGRCm39 Ensembl
GRCm385138,255,482 - 138,259,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,255,482 - 138,259,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,696,710 - 138,700,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,485,519 - 138,489,187 (+)NCBIMGSCv36mm8
Celera5135,238,334 - 135,242,247 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.0NCBI
LAMTOR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,148,918 - 100,154,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,148,912 - 100,155,944 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,746,541 - 99,751,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,584,466 - 99,589,769 (+)NCBINCBI36Build 36hg18NCBI36
Celera794,481,881 - 94,487,184 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,381,502 - 94,386,804 (+)NCBIHuRef
CHM1_1799,676,653 - 99,681,960 (+)NCBICHM1_1
T2T-CHM13v2.07101,379,971 - 101,393,996 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,106,615 - 99,111,919 (+)NCBI
Lamtor4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81222,372,269 - 22,376,090 (+)NCBIGRCr8
mRatBN7.21217,258,656 - 17,262,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1217,258,623 - 17,262,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1218,226,230 - 18,230,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,849,953 - 18,853,729 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,903,365 - 17,907,141 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,573,909 - 19,577,625 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,573,909 - 19,577,624 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,630,758 - 21,634,474 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,839,249 - 17,843,070 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,828,763 - 17,832,586 (+)NCBI
Celera1219,183,368 - 19,187,136 (+)NCBICelera
Cytogenetic Map12q11NCBI
Lamtor4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573645,587 - 694,661 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573649,604 - 653,185 (-)NCBIChiLan1.0ChiLan1.0
LAMTOR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,067,771 - 118,073,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,332,404 - 166,337,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,183,617 - 92,188,967 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,616,074 - 105,621,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,616,074 - 105,621,685 (+)Ensemblpanpan1.1panPan2
LAMTOR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,372,728 - 9,376,047 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,372,715 - 9,375,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha611,076,721 - 11,080,039 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,306,399 - 9,309,717 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,304,576 - 9,309,616 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,158,897 - 9,162,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,137,939 - 9,141,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,319,012 - 9,322,330 (-)NCBIUU_Cfam_GSD_1.0
Lamtor4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,624,807 - 133,628,189 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543408,363 - 411,723 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543408,345 - 411,723 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMTOR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,155,188 - 8,164,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,119,338 - 8,171,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,350,308 - 7,402,741 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMTOR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,916,152 - 12,923,647 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,916,148 - 12,923,609 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,359,144 - 3,364,110 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamtor4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,752,834 - 16,756,069 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,752,834 - 16,756,119 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lamtor4
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:349
Count of miRNA genes:274
Interacting mature miRNAs:300
Transcripts:ENSMUST00000062067, ENSMUST00000160157
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse

Markers in Region
AV006840  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385138,259,251 - 138,259,345UniSTSGRCm38
MGSCv375138,700,479 - 138,700,573UniSTSGRCm37
Celera5135,242,103 - 135,242,197UniSTS
Cytogenetic Map5G2UniSTS
Whitehead/MRC_RH51670.77UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062067   ⟹   ENSMUSP00000056693
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,253,744 - 138,257,657 (+)Ensembl
GRCm38.p6 Ensembl5138,255,482 - 138,259,395 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,254,093 - 138,257,660 (+)Ensembl
GRCm38.p6 Ensembl5138,255,831 - 138,259,398 (+)Ensembl
RefSeq Acc Id: NM_001081108   ⟹   NP_001074577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,253,744 - 138,257,657 (+)NCBI
GRCm385138,255,482 - 138,259,395 (+)ENTREZGENE
MGSCv375138,696,710 - 138,700,623 (+)RGD
Celera5135,238,334 - 135,242,247 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074577 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI44959 (Get FASTA)   NCBI Sequence Viewer  
  BAC24993 (Get FASTA)   NCBI Sequence Viewer  
  BAC25020 (Get FASTA)   NCBI Sequence Viewer  
  BAC25306 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000056693
  ENSMUSP00000056693.7
GenBank Protein Q8CF66 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001074577   ⟸   NM_001081108
- UniProtKB: Q8CEW4 (UniProtKB/Swiss-Prot),   B7ZN18 (UniProtKB/Swiss-Prot),   Q8CF77 (UniProtKB/Swiss-Prot),   Q8CF66 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000056693   ⟸   ENSMUST00000062067

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CF66-F1-model_v2 AlphaFold Q8CF66 1-99 view protein structure

Promoters
RGD ID:6888512
Promoter ID:EPDNEW_M7707
Type:initiation region
Name:Lamtor4_1
Description:Mus musculus late endosomal/lysosomal adaptor, MAPK and MTORactivator 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385138,255,754 - 138,255,814EPDNEW
RGD ID:6836962
Promoter ID:MM_KWN:44551
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000062067,   OTTMUST00000054525
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365138,696,701 - 138,697,537 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913346 AgrOrtholog
Ensembl Genes ENSMUSG00000050552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000062067 ENTREZGENE
  ENSMUST00000062067.8 UniProtKB/Swiss-Prot
InterPro LAMTOR4 UniProtKB/Swiss-Prot
KEGG Report mmu:66096 UniProtKB/Swiss-Prot
MGD MGI:1913346 ENTREZGENE
NCBI Gene 66096 ENTREZGENE
PANTHER PTHR33967 UniProtKB/Swiss-Prot
  RAGULATOR COMPLEX PROTEIN LAMTOR4 UniProtKB/Swiss-Prot
PhenoGen Lamtor4 PhenoGen
UniProt B7ZN18 ENTREZGENE
  LTOR4_MOUSE UniProtKB/Swiss-Prot
  Q8CEW4 ENTREZGENE
  Q8CF66 ENTREZGENE
  Q8CF77 ENTREZGENE
UniProt Secondary B7ZN18 UniProtKB/Swiss-Prot
  Q8CEW4 UniProtKB/Swiss-Prot
  Q8CF77 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Lamtor4  late endosomal/lysosomal adaptor, MAPK and MTOR activator 4  0910001L09Rik  RIKEN cDNA 0910001L09 gene  Symbol and/or name change 5135510 APPROVED