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Gene: HOXD4 (homeobox D4) Homo sapiens
Symbol: HOXD4
Name: homeobox D4
Description: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HHO.C13; homeo box d4; homeobox protein HHO.C13; homeobox protein Hox-4B; homeobox protein Hox-5.1; homeobox protein Hox-D4; Hox-4.2; Hox-4.2, mouse, homolog of homeo box X; HOX-5.1; HOX4; HOX4B
Mus musculus (house mouse) : Hoxd4 (homeobox D4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hoxd4 (homeo box D4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hoxd4 (homeobox D4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hoxd4 (homeobox D4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382176,150,394 - 176,156,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372177,015,122 - 177,017,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362176,724,359 - 176,726,197 (+)NCBINCBI36hg18NCBI36
Build 342176,841,619 - 176,843,454NCBI
Celera2170,625,292 - 170,627,130 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2168,892,961 - 168,894,799 (+)NCBIHuRef
CHM1_12177,021,982 - 177,023,820 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HOXD4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320172
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.